partition coefficient in situ method of permeability in vivo method of permeability in vitro method of permeability biowaiver class of boundaries permeability solubility class 4 drug class 3 drug class 2 drug class 1 drug generic substitution special concerns in bioavailability and bioequival clinical significance of bioequivalence studies generic biologics ( biosimilar drug product) methods of permeability biopharmaceutical classification system laue photographic method different x-ray diffraction technique x-ray crystallography r powder method powder crystal method bragg's specrtometer method laue method crystallography x-ray x ray crystallograph brags law braggs law brag law rotating crystal method type of crystal diffrection technique x-ray crystallography application bragg's law x- ray crystallography
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