Possibilities for 3D Printing in the Life Sciences Market - June'13

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Possibilities for 3D Printing in the Life Sciences Market - June'13

  1. 1. 2013 RNCOS Possibilities for 3D Printing in the Life Sciences Market
  2. 2. Possibilities for 3D Printing in the Life Sciences Market Rapid advances in technology and breakthrough results in various R&D experiments suggest new applications for 3D printing in the life sciences and medical world. Recent 3D Bio-printing Breakthroughs • Scientists from the Herlot-Watt University, Edinburg successfully 3D- printed embryonic stem cells • Artificial skull 3D printed by Scientists at Oxford Performance Materials replaced 75% of the skull of an American patient • Scientists at LayerWise created an implantable lower jaw for a patient in Netherlands • A cancer patient who had his left face missing due to a surgery to remove tumor, was implanted with a 3D printed prosthetic face • Researchers at Cornell University created a living human ear using a 3D printer • Scientists at Oxford University developed a 3D printer that can create living tissues. Introduction Being in oblivion for almost three decades, 3D printing has recently garnered much limelight. So much so that Wall Street analysts are promoting the 3D printing industry as the next big thing after the internet revolution. With high stakes being placed on market players, we decided to look into the applications of 3D printing in life sciences and whether or not it has the potential to deliver on the high expectations. The Technology 3D printing is an additive manufacturing process, wherein the product is manufactured by adding the raw material layer by layer, following a successive bottom-up approach. The process begins by first designing a digital CAD file for the desired product. This CAD file is used to instruct the 3D printer. Further, raw materials for the final product are fed into the appropriate portal. Once instructions are given, it takes only a few minutes for the 3D printer to manufacture the final product. Market Dynamics With varied applications in aeronautical engineering, prototype designing and immense potential for growth in the medical industry, the market for 3D printing is expected to grow at CAGR of around 22% between 2012-2017 to reach a value of US$ 3.4 Billion by the end of forecast period. Advances in technology are expected to decrease the 3D printer’s size, while enhancing its ability to manufacture complex designs. This will further fuel its growth by adding onto its applications and increasing its usability.
  3. 3. Possibilities in Life Sciences Dentistry: 3D printing is revolutionizing the way artificial dentures are made. Gone are the days when patients had to rely on uncomfortable, foul-tasting, and less accurate oral impressions using trays and molding materials. Now, the patient has to just sit and let the dentist take a 3D scan of the teeth. The digital data of the scan is converted into a CAD file and uploaded into a computer. This file can then be used to get the denture printed from an in-house printer or a local firm with a 3D printer. Although, a lot of small firms are mushrooming up that provide these services for a nominal fee, with decreasing cost of a 3D printer and its rising affordability, it is expected that the trend of having an in-house 3D printer will soon catch up amongst medium scale dentists in the developed regions. Organ Modeling: The technology has immense scope in the field of manufacturing prosthetic limbs and other body organs. Currently, its use ranges from manufacturing organ models for surgeons to evaluate medical procedures to manufacturing of human skulls and jaws for transplantation procedures. 3D printing has also brought about a sea change in how prosthetic limbs are made and customized. Manufactures are using the technology to produce customized prosthetic limb coverings, or fairings, that perfectly mirror the sculptural symmetry and function of the wearer's remaining limb. The major advantage of producing prosthetic limbs and transplantable jaw, skull and other organs where living tissues are not required is that it reduces the surgery time. Chief reason behind the reduction in surgery time is the personalized manufacturing of the implant. The implant fits perfectly into the patient’s body, reducing hospital stay and the overall medical costs. In its nascent stages, the rising popularity of prosthetic limbs designed using 3D printing is all set to boost the growth of the 3D printers market. Drug R&D: Currently, millions of dollars and substantial time is wasted if a drug candidate that passed efficacy studies in animal models is found toxic in clinical trials. To reduce this wastage, 3D printers can offer a very viable solution. Imagine a microchip with uniformly spaced human target tissues, wherein the metabolism and toxicity of the drug can be studied. In a recent development, a 3D printer was used to evenly print uniform-size droplets of stem cells gently enough to keep the cells alive and maintain their ability to develop into different cell types. These stem cells can be induced to transform into the desired differentiated cells and observed upon for the application of drug. A lot of research is required before such technique can be routinely used by the pharma firms, still, recent researches and collaborations between players in the 3D printing market and big pharma are an indication of the growth of this application in the field.
  4. 4. • 3D printed implantable dentures and prosthetics are finding increased acceptability and rise in demand as they can be produced in a significantly shorter time and budget • 3D printing provides the ability to built a scaffold with high integrity and carefully planned porosity, giving immense advantage for use in tissue engineering Tissue Engineering: This by far, remains the most lucrative and underdeveloped segment of all. Lucrative because it has the potential to fill in the wide gap in demand and supply of organs; underdeveloped because of the sensitive nature of the research involved. The technology provides with an opportunity to produce things which can’t be produced otherwise. For instance, one can print porous titanium structures which allow bone in-growth and allow a better fixation of the implant, giving it a longer lifetime. The technology could involve the creation of replacement tissues and organs that are printed layer-by-layer into a three-dimensional structure. Parts could be made from the organ recipient's own genetic matter, and precisely match the tissue or organ they replace. Since these printed organs or tissue will be made from the patient's own cells rather than those of a donated heart or liver, there'll little risk of an immune response, which lessens the need for debilitating immunosuppressive drugs. Breakthroughs in the field are increasing in frequency. Market players are forming collaborations with leading research centers and universities to work on a viable solution. Recent advances in the field involve manufacturing of simple tissues like skin, heart muscle patches, and blood vessels. Moreover, researchers have successfully produced miniature functional kidneys using 3D printing and are now working on developing more sophisticated prototypes. Researchers are also focusing on producing ear, muscle, and cartilage-bone using 3D printing. The field is at the research level phase. Once enough data is accumulated, the research is bound to reach clinical trial stages. The current scenario suggest that the initiation of such clinical trials could begin in the next 5-6 years and in the next 15-20 years, the technology to manufacture organs using 3D printing and recipient’s cells can be expected to become a common practice reducing the organ demand supply gap and saving precious lives. Conclusion Currently, the medical and life sciences sector accounts for only a marginal share of about 15% in the total 3D printing industry. Of this, the majority of revenue is being generated through the manufacturing of dentures and prosthetic limbs. However, immense potential lies in the applications that the technology can have in transforming pharmaceutical R&D and manufacturing complete organs. Players in the industry thus need to focus on two aspects. First, they should try to provide viable solutions and cater to the ever increasing demand from consumers for direct digital manufacturing. Second, while generating revenue and
  5. 5. Key Take-aways • Trend of keeping in-house 3D printers s augment in US dental clinics • Players will find increased demand from implantable prosthetics market • Tissue scaffolds will be increasingly manufactured using 3D printers which will boost the regenerative medicine and surgery market • Research impetus will be on efforts of manufacturing whole organs using 3D printing technology maintaining profits, a considerable amount of revenue should be utilized to invest in R&D to increase the usability of the technology in the medical field. Collaborations with research institutes with an eye on federal funds can be a positive move in the direction.
  6. 6. Looking for an in-depth study Our Proposition RNCOS is a leading Business Consultancy firm helping its clients to enter new geographies and in attaining growth by developing market strategies for them. Critical questions that businesses need to address: • Where should you set up your business? • Who should be your distributors? • What is the current market structure & size? • Who should be your customers? We understand your immediate needs and your long-term goals and objective and work with you on how to accomplish them. RNCOS blends the best of strategy consulting with the best of market research to provide organizations with accurate, succinct answers to their most important business questions. Our offerings Market Insights • What is the market size • Structure of the market • Who are buyers • Buyers’ buying behavior • Expectations from the product Identification • Most suitable distributors and channels for your business. • Analyzing their strength, credibility, scale of operations. • Assisting in distributor selection Product Segments • Similar products in the market • Features, attributes & market share of these products • Customer preferences • Price range of these products Competitive Assessment • Financial & strategic analysis of existing competition • Acceptance level among customers • Emerging competitors • New market entrants GROWTH PARTNER We help you make informed decisions through the practical application of research, hand holding you to your success…
  7. 7. For more information on how we can work with you Contact VARTIKA SEHGAL Sr. Research Specialist RNCOS E mail: vartika.sehgal@rncos.com Website: www.rncos.com Phone: +91 120 4224700 /01 / 02/ 03 Address: B 129, Sector 6, Noida, Uttar Pradesh India - 201301

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