RHEUMATOID ARTHRITIS

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RHEUMATOID ARTHRITIS

  1. 1. Rheumatoid arthritis
  2. 2. Rheumatoid arthritis (often called RA) is a chronic (long-standing) disease that damages the joints of the body. 30 NOVEMBER 2009
  3. 3. INTRODUCTION <ul><li>Rheumatoid arthritis affects approximately 1% of world population, with women developing the condition three times more than men. </li></ul><ul><li>Juvenile rheumatoid arthritis (JRA) causes joint inflammation and stiffness for more than six weeks in a child aged 16 or younger. </li></ul><ul><li>Even though infectious agents such as viruses, bacteria, and fungi have long been suspected, the cause of rheumatoid arthritis is unknown. </li></ul>30 NOVEMBER 2009
  4. 4. An example showing the differences between a normal, healthy joint, a joint affected by osteoarthritis, and one affected by rheumatoid arthritis. 30 NOVEMBER 2009
  5. 5. Signs and symptoms <ul><li>The symptoms of rheumatoid arthritis come and go, depending on the degree of tissue inflammation. </li></ul><ul><li>Symptoms can include fatigue, lack of appetite, low-grade fever, muscle and joint aches, and stiffness. </li></ul>30 NOVEMBER 2009
  6. 6. Diagnosis <ul><li>Blood test </li></ul><ul><li>X-ray </li></ul>30 NOVEMBER 2009
  7. 7. TREATMENT <ul><li>Two classes of medications are used in treating rheumatoid arthritis: </li></ul><ul><li>fast-acting &quot;first-line drugs&quot; and </li></ul><ul><li>slow-acting &quot;second-line drugs.“ </li></ul><ul><li>Symptomatic pain relief can often be achieved with oral acetaminophen (Tylenol and others) or OTC topical preparations. </li></ul>30 NOVEMBER 2009
  8. 8. The areas of the body, other than the joints, that are affected by rheumatoid inflammation are treated individually. 30 NOVEMBER 2009
  9. 9. MARKET SHARE OF DIFFERENT CLASSES 30 NOVEMBER 2009
  10. 10. OVERALL MARKET SHARE OF DRUGS 30 NOVEMBER 2009
  11. 11. SURVEY NSAIDs DRUGS BRANDS STARS Hydroxychloroquine HYDROCAB ** ACETYLSALICYL-ATE ACE-PROXYVON *** NAPROXEN NAPROSYN * IBUPROFEN ABUFEN-C * ETODOLAC ETOLOR * PARACETAMOL CALPOL **** DICLOFENAC MISONAC ** CELECOXIB CELEDOL * D-PENICILLAMINE CILAMIN * AURANOFIN AUROCRIS * Immunosuppressive drugs DRUGS BRANDS STARS Azathioprine imuran * Cyclophosphamide cycloxan * chlorambucil leukeran * cyclosporin Sandimmune neoral * methotrexate folitrax *** corticosteroids DRUGS BRANDS STARS prednisolone wysolone ***
  12. 12. <ul><li>1.http://kidshealth.org/parent/general/body_basics/bones_muscles_joints.html. assessed on 17/9/09. </li></ul><ul><li>2. Majithia V, Geraci SA (2007). &quot;Rheumatoid arthritis: diagnosis and management&quot;. page no: 936–9. </li></ul><ul><li>3. Landré-Beauvais AJ (1800). La goutte asthénique primitive (doctoral thesis). Paris.  &quot;The first description of rheumatoid arthritis. Unabridged text of the doctoral dissertation presented in 1800&quot;. Joint Bone Spine 68 (2): 130–43.  </li></ul><ul><li>4. Turesson C, O'Fallon WM, Crowson CS, Gabriel SE, Matteson EL (2003). &quot;Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years&quot;. page no: 722–7. </li></ul><ul><li>5. Westwood OM, Nelson PN, Hay FC (April 2006). &quot;Rheumatoid factors: what's new?&quot;. Rheumatology (Oxford) page no: 379–85. </li></ul><ul><li>6. Nishimura K, Sugiyama D, Kogata Y, et al (June 2007). &quot;Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis&quot; page no:797–808. </li></ul><ul><li>7. Arnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N, Healey L, Kaplan S, Liang M, Luthra H (1988). &quot;The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis . &quot;. Arthritis Rheum page no: 315–24. </li></ul><ul><li>8.O'Dell J (2004). &quot;Therapeutic strategies for rheumatoid arthritis.&quot;. N Engl J Med page no : 2591–602. </li></ul>30 NOVEMBER 2009
  13. 13. <ul><li>9.Hasler P (June 2006). &quot;Biological therapies directed against cells in autoimmune disease.&quot;. Springer Semin Immunopathol page no:443–56. </li></ul><ul><li>10. Vital E, Emery P (Sep 15 2005). &quot;Advances in the treatment of early rheumatoid arthritis . &quot;.page no: 1002, 1004. </li></ul><ul><li>11.http://www.fda.gov/Drugs/ResourcesForYou/HealthProfessionals/ucm107046.htm assessed on </li></ul><ul><li>12. Edwards J, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close D, Stevens R, Shaw T (2004). &quot;Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.&quot;.page no: 2572–81. </li></ul><ul><li>13. Fresenius HemoCare, Inc., &quot;New Hope for Rheumatoid Arthritis Patients,&quot; press release, September 17, 1999. </li></ul><ul><li>14.Hart FD (March 1976). &quot;History of the treatment of rheumatoid arthritis&quot;.page no: 763–5. </li></ul><ul><li>15. Franke A, Reiner L, Pratzel HG, Franke T, Resch KL (August 2000). &quot;Long-term efficacy of radon spa therapy in rheumatoid arthritis--a randomized, sham-controlled study and follow-up&quot;. Page no:894–902..  </li></ul><ul><li>16.S. Wright, M. Ware and G. Guy (2006). &quot;The use of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis ) &quot;.page no: 781. </li></ul><ul><li>17. http://www.ayurveda-herbal-remedy.com/discover-ayurveda/amavata.html </li></ul><ul><li>18. http://holisticonline.com/Remedies/Arthritis/arth_RA_homeopathy.htm </li></ul>30 NOVEMBER 2009
  14. 14. Thank - you

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