Pharmacokinetics shourov

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Pharmacokinetics

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Pharmacokinetics shourov

  1. 1. The scientific name of a medicine. given it by the inventor companyExample Ciprofloxacin Azithromycin
  2. 2. A name given by the manufacturer to a particular product or service.Example: Radiant Pharmaceuticals Ltd. Square Ciprocin Pharmaceuticals Ltd.
  3. 3. EXAMPLE BRAND NAME GENERIC NAME
  4. 4. DOSAGE FORM/ PRESENTATION Dosage Form: the physical form in which a drug is produced and dispensed such as a tablet, a capsule, or an injection.Tablet Capsule Injection.
  5. 5. DOSAGE FORM/ PRESENTATIONSyrup Suspension SuppositorySoft gelatin capsule
  6. 6. STRENGTH The strength of a drug product tells how much of the active ingredient is present in each dosage (capsule/tablet). STRENGTHExample: Paracetamol -500mg, Ciprofloxacin- 250 mg/500mg
  7. 7. Therapeutic DoseThe dose (amount of a medication ) that required to produce a desired effect.Example: Therapeutic dose of Paracetamol  500 mg, Omeprazole  20 mg Sub Therapeutic Dose The dosage of a drug less than the amount required for a therapeutic effect.
  8. 8. BioavailabilityAmount of Drug that reaches in the systemic circulation (blood) after administration.IV bioavailability is 100%
  9. 9. Bioavailability IV Oral
  10. 10. PharmacokineticsThe branch of pharmacology deals with the movement of drugs within the body. Absorption Elimination Pharmacokinetics Distribution Metabolism
  11. 11. PharmacodynamicsThe branch of pharmacology concerned with the effects of drugs and the mechanism of their action.Pharmacokinetics • What drug does to the bodyPharmacodynamics • What body does to the drug
  12. 12. Elimination Half life (t1/2)The time necessary for the concentration of drug in the plasma to decrease by half. 80 t1/2 = (9- 3) = 6hr 40 t1/2 0 3 9
  13. 13. Peak Plasma Poncentration (Cmax)The maximum plasma concentration of a drug achieved in the blood after a dose administered. 80 Cmax 40 0
  14. 14. TmaxThe amount of time that a drug is present at the maximum concentration in serum Tmax 0 3 9
  15. 15. AUCArea under the concentration curve (AUC)Availability of a drug in the body for a given period AUC Greater AUC better for patient
  16. 16. MICMinimum inhibitory concentrationThe lowest concentration of an antibiotic that is needed to inhibit bacterial growth. MIC
  17. 17. MECminimum effective concentration The lowest concentration of an drug that is needed to give pharmacological effect. MIC
  18. 18. Therapeutic IndexThe ratio between the toxic dose and the therapeuticdose of a drug. TI = LD50 /ED50
  19. 19. First Pass Effect/MetabolismAfter absorption of oral drug it have to pass through the liver. Then it enter into the circulation. In the liver the drug may or may not be metabolized. This process is called First pass effect. Therapeutic Effect Mouth Absorption Liver Circulation Elimination Metabolism
  20. 20. Potency: Amount of drug required to produce particular response Efficacy: Maximum response produced by a drug Efficacy Potency
  21. 21. COGS (Cost Of goods sold) TP (Trade Price) Invoice Price MRP(Maximum retail price)
  22. 22. COGSCost of Packaging, Raw materials, over head cost TPCOGS + Profit MarginInvoice PriceTP + 16% VAT MRPInvoice price + Chemist margin

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