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Marine drugs
 The drugs which are obtained from marine organisms
are know as marine drugs. these drugs are used since
ancient times.
...
 Rich source of both biological and chemical diversity
(The oceans are our most biodiverse environment).
 Genetic divers...
 Sponges
 Coelenterates (sea whips, sea fans and soft corals)
 Tunicates
 molluscs (nudibranchs, sea hares, etc.)
 Ec...
Sponges Tunicates
bryozon
mollusks
 Antibacterial agents
 Antiviral agents
 Antifungal agents
 Antibiotics
 Anticancer agents
 Antiprotozoal agents
 A...
Compound
Name
Source Chemical
class
Disease
area
Status
Ziconotide(prialt™) cone snail Peptide Chronic pain approval
by th...
 1st drug of marine origin
 approval by the FDA on December 31st 2004
 A non-opioid, non-NSAID, non-local anesthetic us...
 Used for “management of severe chronic pain”
 Approved for the treatment of chronic pain as a
morphine replacement ther...
 Blocks the N-Type calcium channels on the primary
nerves in the spinal cord
 Ecteinascidin
 Didemnin B
 Dolastin-10
 Halichondrin B
 Bryostatin-1
 Aplidin (APL)
 Expression of silent biosynthetic pathways
 Culturing/cultivating organisms for production
-Supply Issue
-macro and mic...
 The marine ecosystem is not only productive to
discover novel entities but it is also a tool to identify
new cellular ta...
 Sources for developing potent drug candidates
 In cosmetics
 As nutritional supplements
 As molecular probes that can...
 Molinski, T.F.; Dalisay, D.S.; Lievens, S.L.; Saludes,
J.P. Drug development from marine natural
products. Nat. Rev. Dru...
Marine drugs
Marine drugs
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Marine drugs

marine drugs presentation for seminar

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Marine drugs

  1. 1. Marine drugs
  2. 2.  The drugs which are obtained from marine organisms are know as marine drugs. these drugs are used since ancient times.  They are highly potent bioactive molecules  In recent years a significant number of novel metabolites with potent pharmacological properties have been discovered from the marine organism
  3. 3.  Rich source of both biological and chemical diversity (The oceans are our most biodiverse environment).  Genetic diversity translates to chemical diversity = Promising new drugs  Marine toxins were reported to possess an extremely high potency with regard to their pharmacological actions.  Low toxic side effects.
  4. 4.  Sponges  Coelenterates (sea whips, sea fans and soft corals)  Tunicates  molluscs (nudibranchs, sea hares, etc.)  Echinoderms (starfish, sea cucumbers, etc.)  Bryozoans (moss animals)
  5. 5. Sponges Tunicates bryozon mollusks
  6. 6.  Antibacterial agents  Antiviral agents  Antifungal agents  Antibiotics  Anticancer agents  Antiprotozoal agents  Anti-inflammatory agents
  7. 7. Compound Name Source Chemical class Disease area Status Ziconotide(prialt™) cone snail Peptide Chronic pain approval by the FDA on December 31st 2004 Bryostatin-1 Bryozoan Polyketide Cancer No current clinical trials Dolaststin Sea slug Peptide Cancer - E-7974 Sponge tripeptide cancer Phase-1
  8. 8.  1st drug of marine origin  approval by the FDA on December 31st 2004  A non-opioid, non-NSAID, non-local anesthetic used for treatment of chronic pain  Derived from the toxin of cone snail Conus magus  Contains synthetic form of the cone snail peptide ω- conotoxin
  9. 9.  Used for “management of severe chronic pain”  Approved for the treatment of chronic pain as a morphine replacement therapy  It is the most powerful painkiller known till date  Must be administered intrathecally  Common side effects: dizziness, nausea, confusion & headache  Rare side effects: hallucinations, suicidal thoughts, new or worsening depression, meningitis and seizures Cont.
  10. 10.  Blocks the N-Type calcium channels on the primary nerves in the spinal cord
  11. 11.  Ecteinascidin  Didemnin B  Dolastin-10  Halichondrin B  Bryostatin-1  Aplidin (APL)
  12. 12.  Expression of silent biosynthetic pathways  Culturing/cultivating organisms for production -Supply Issue -macro and micro-organisms  Toxicity issues
  13. 13.  The marine ecosystem is not only productive to discover novel entities but it is also a tool to identify new cellular targets for therapeutic intervention”
  14. 14.  Sources for developing potent drug candidates  In cosmetics  As nutritional supplements  As molecular probes that can be supported to increase the healthy life span of human.
  15. 15.  Molinski, T.F.; Dalisay, D.S.; Lievens, S.L.; Saludes, J.P. Drug development from marine natural products. Nat. Rev. Drug Discov. 2008, 8, 69–85.  Montaser, R.; Luesch, H. Marine natural products: A new wave of drugs? Future Med. Chem. 2011, 3, 1475–1489.

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