Stemcells

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Stemcells

  1. 1. Presented by T.SHIVAKUMAR Shiva.pharmacist@gmail.comKOTTAM INSTITUTE OF PHARMACY
  2. 2. DEFINITION Stem cells ar e the generic cells w hich ar e a class ofundif ferentiated cells that ar e able to dif ferentiated into specialized cell
  3. 3. SOURCESTHE MAJOR SOURCES OF STEMCELLS ARE Embryos Adult tissues/organs Umbilical cords Cadavers (survival of neural progenitor cells from human post-mortem tissues up to 20hr after death)
  4. 4. TYPESBASED ON THE TYPE OF ORIGIN AND POTENCY EMBRYONIC STEM CELLS ADULT STEM CELLS
  5. 5. PROPERTIES Self-renewal The ability to go through numerous cycles cell division by maintaining undifferentiated state Potency The capacity to differentiate into specialized cell types
  6. 6. Self-renewalTwo mechanisms are involved• Obligatory asymmetric replication• Stochastic differentiation
  7. 7. POTENCYPotential classification includes Totipotent: Ex: zygote Pluripotent: Ex: embryonic stem cells Multipotent: Ex: hematopoietic stem cells(RBC&WBC) Oligopotent: Ex: lymphoid/myeloid stem cells Unipotent: Ex: muscle stem cells
  8. 8. IDENTIFICATION Examining chromosomes under microscope Presence of surface markers 1.Transcription factors like proteins oct-4,nanog,sox-2 2.Cellsurface antigens- glycolipids,keratan sulfate antigen
  9. 9. STEM CULTURES
  10. 10. TREATMENTS
  11. 11. THERAPIES ADULT STEMCELL TRANSPLANT BONE MARROW STEM CELLS ADULT STEMCELL TRANSPLANT PERIPHERAL BLOOD STEM CELLS UMBILICAL CORD BLOOD STEM CELL TRANSPLANT
  12. 12. STEM CELL TRANSPLANTSBONE MARROW STEM CELLS Umbilical Cord Blood Stem Cell Transplant
  13. 13. CAN THESE STEM CELLS CURE HEARTDISEASES?  Rodent Model of Myocardial Infarction
  14. 14. Heart Muscle Repair with Adult Stem Cells
  15. 15. CONCLUSION Now days these stem cells areeffectively used in thetreatment of heart diseases &addressing the nations leadingcauses of death.

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