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MYCOBACTERIA
‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ئ‬‫کو‬‫ی‬‫ئ‬‫ما‬
‫اس‬Genus‫ں‬‫ی‬‫ہ‬ ‫ل‬‫م‬‫ا‬‫ش‬‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫و‬‫ج‬‫ں‬‫ی‬‫م‬-‫ہ‬‫طرح‬ ‫کی‬ ‫راڈز‬ ‫وو‬‫ں‬‫ی‬‫ہ‬ ‫ے‬‫وت‬-‫ھی‬‫ب‬‫کو‬ ‫سڈ‬‫ی‬‫ا‬
‫ں‬‫ی‬‫ہ‬ ‫ے‬‫وت‬‫ہ‬‫م‬‫ح‬‫ا‬‫ز‬‫م‬–‫ی‬‫ن‬‫ع‬‫ی‬Acid fast‫ں‬‫ی‬‫ہ‬ ‫ے‬‫وت‬‫ہ‬-‫اری‬‫م‬‫ی‬‫ب‬‫اری‬‫ش‬‫ت‬‫ہ‬‫ب‬‫اور‬‫ا‬‫د‬‫ی‬‫ب‬‫اں‬
‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬-
 Mycobacterium Tuberculosis
 Mycobacterium bovis
 Mycobacterium Leprae
 Atypical Mycobacterium
• M. kansasii
• M. marinum
• M. avium-intracellulare complex
• M. fortuitum-chelonei complex
MYCOBACTERIUM TUBERCULOSIS
‫ے‬‫ہ‬ ‫زم‬‫ارگی‬‫و‬‫ٹ‬‫ب‬‫از‬‫ی‬‫ام‬‫ر‬‫گ‬ ‫ا‬‫ک‬ ‫ل‬‫ک‬‫ش‬ ‫کی‬ ‫راڈ‬ ‫ہ‬‫ی‬-‫کے‬‫و‬‫ج‬Ziehl–Neelsen stain
‫ی‬‫ن‬‫ع‬‫ی‬Z.N‫ں‬‫ی‬‫ہ‬‫ے‬‫ت‬‫ی‬‫ل‬ ‫گ‬‫ی‬‫ر‬ ‫سرخ‬‫سے‬‫ن‬‫ی‬‫ٹ‬‫س‬-‫ب‬‫سے‬‫سڈ‬‫ی‬‫ا‬ ‫اور‬‫ے‬‫کرت‬ ‫ت‬‫م‬‫ح‬‫ا‬‫ز‬‫م‬ ‫ھی‬‫ں‬‫ی‬‫ہ‬
‫اور‬‫ے‬‫ت‬‫ے‬‫وت‬‫ہ‬‫ں‬‫ی‬‫ہ‬‫ب‬‫گ‬‫ی‬‫ر‬-‫ہ‬‫ی‬ ‫ے‬‫ت‬‫ل‬ ‫اس‬Smear‫ر‬‫ظ‬‫ی‬ ‫راڈ‬ ‫کی‬ ‫گ‬‫ی‬‫ر‬ ‫سرخ‬‫ں‬‫ی‬‫م‬‫ی‬‫آت‬
‫ے‬‫ہ‬-‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫ا‬‫ک‬ ‫گ‬‫ی‬‫ر‬‫لے‬‫ی‬‫ب‬ ‫ڈ‬‫اؤی‬‫ر‬‫گ‬ ‫ک‬‫ی‬‫ب‬‫ی‬‫اق‬‫ی‬‫کے‬‫ی‬‫ج‬-

CULTURAL CHARACTERISTICS ‫ات‬‫ی‬‫ص‬‫صو‬‫خ‬‫کی‬ ‫ر‬‫چ‬‫ل‬‫ک‬
‫ں‬‫ی‬‫م‬‫ری‬‫ارٹ‬‫ی‬‫ی‬‫ل‬ ‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ہ‬‫ی‬Grow‫ے‬‫ہ‬‫ام‬‫ک‬ ‫ل‬‫ک‬‫ش‬‫م‬‫ا‬‫ی‬‫ر‬‫ک‬-‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ام‬‫ع‬ ‫ہ‬‫ی‬‫ت‬‫ق‬‫و‬‫د‬‫زای‬‫سے‬‫ا‬
‫ے‬‫ہ‬ ‫ا‬‫ی‬‫ی‬‫ل‬-‫ا‬‫ل‬‫م‬‫ع‬‫ا‬‫ک‬ ‫ے‬‫ت‬‫ی‬‫ب‬ ‫دو‬‫سے‬‫ک‬‫ی‬‫ا‬‫کہ‬ ‫ے‬‫ہ‬ ‫ہ‬‫ی‬‫ہ‬‫وج‬ ‫کی‬ ‫اس‬‫ت‬‫ہ‬‫ب‬‫ں‬‫ی‬‫م‬ ‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫س‬
‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫ت‬‫س‬‫س‬-
ً
‫ا‬‫ی‬‫ب‬‫ر‬‫ق‬‫ی‬ ‫اور‬18‫ں‬‫ی‬‫ہ‬ ‫ے‬‫ت‬‫گ‬‫ل‬‫ے‬‫ت‬‫ی‬‫ھ‬‫گ‬-Mycobacterium‫ے‬‫ت‬‫ل‬ ‫کے‬
‫م‬‫اصی‬‫خ‬‫ھی‬‫ح‬‫ا‬‫ن‬‫ی‬‫ب‬‫رو‬‫ٹ‬‫ں‬‫ی‬‫م‬‫س‬‫ج‬‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫ار‬‫ک‬‫در‬ ‫م‬‫ی‬‫ڈ‬‫ی‬‫م‬ ‫ا‬‫س‬‫ی‬‫ا‬‫و‬‫ہ‬‫ود‬‫موج‬‫ں‬‫ی‬‫م‬‫ار‬‫د‬‫ق‬-
ً
‫ال‬‫ی‬‫م‬
‫ن‬‫ی‬‫ب‬‫رو‬‫ٹ‬ ‫کی‬ ‫ڈے‬‫ای‬-‫ل‬ ‫کے‬‫ری‬‫ڑھوٹ‬‫ٹ‬ ‫ے‬‫ت‬‫ب‬ ‫ا‬‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ہ‬‫ی‬‫سوس‬‫ح‬‫م‬‫رورت‬‫ض‬ ‫کی‬ ‫ن‬‫ج‬‫ی‬‫س‬‫ک‬‫آ‬‫ے‬‫ت‬
‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬-
‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫ال‬‫م‬‫ع‬‫ت‬‫س‬‫ا‬‫ر‬‫ٹ‬ ‫طور‬‫ام‬‫ع‬ ‫م‬‫ی‬‫ڈ‬‫ی‬‫م‬‫و‬‫ج‬ ‫ے‬‫ت‬‫ل‬ ‫کے‬ ‫صد‬‫ق‬‫م‬‫اس‬-‫ام‬‫ی‬‫ا‬‫ک‬ ‫اس‬
Lowenstein-Jensen (LJ) medium‫ے‬‫ہ‬-‫الون‬‫ک‬ ‫ر‬‫ٹ‬ ‫م‬‫ی‬‫ڈ‬‫ی‬‫م‬ ‫اس‬‫ز‬‫ی‬
‫ں‬‫ی‬‫ہ‬ ‫ی‬‫وت‬‫ہ‬ ‫کی‬ ‫گ‬‫ی‬‫ر‬ ‫م‬‫ی‬‫کر‬ ‫ا‬‫ی‬‫د‬‫ی‬‫ف‬‫ش‬ ‫ک‬‫س‬‫ج‬ ، ‫ی‬‫وت‬‫ہ‬ ‫ھری‬‫ب‬‫ا‬-‫ک‬‫کو‬ ‫ل‬‫ی‬‫و‬‫ب‬‫ر‬‫چ‬‫ل‬6-8‫کے‬ ‫ے‬‫ت‬‫ف‬‫ہ‬
‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬ ‫ہ‬‫ن‬‫ب‬‫ا‬‫ع‬‫م‬‫عد‬‫ی‬-
Mycobacteria
‫سے‬‫زی‬‫ی‬‫ن‬Grow‫ے‬‫ت‬‫ل‬ ‫کے‬‫ے‬‫کرت‬Middlebrook medium
BACTEC‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬ ‫ال‬‫م‬‫ع‬‫ت‬‫س‬‫ا‬-‫ہ‬‫ج‬‫ی‬‫ی‬‫ب‬‫ں‬‫ی‬‫م‬ ‫س‬‫ج‬2‫ے‬‫ہ‬‫ا‬‫ی‬‫آ‬‫عد‬‫ی‬ ‫ے‬‫ت‬‫ف‬‫ہ‬-
PATHOGENICITY ‫اں‬‫اری‬‫م‬‫ی‬‫ب‬
Mycobacterium tuberculosis‫اور‬Mycobacterium
leprae‫وں‬‫اب‬‫س‬‫ی‬‫ا‬‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬ ‫ا‬‫د‬‫ی‬‫ب‬‫اں‬‫اری‬‫م‬‫ی‬‫ب‬‫ں‬‫ی‬‫م‬-‫اور‬TB‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬ ‫ا‬‫د‬‫ی‬‫ب‬–‫دو‬‫ہ‬‫ی‬
‫ے‬‫ہ‬ ‫ی‬‫وت‬‫ہ‬‫کی‬ ‫م‬‫س‬‫ق‬-
Primary:‫م‬‫م‬‫س‬‫ج‬ ‫ہ‬‫ن‬‫ب‬‫ر‬‫م‬ ‫لی‬‫ہ‬‫ب‬ ‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ں‬‫ی‬‫م‬‫اری‬‫م‬‫ی‬‫ب‬ ‫اس‬‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬ ‫ل‬‫خ‬‫دا‬‫ں‬‫ی‬-‫اور‬
‫ے‬‫ہ‬‫ا‬‫ی‬‫ہ‬‫ر‬ ‫ا‬‫ی‬‫ھ‬‫ڑ‬‫ٹ‬ ‫ہ‬‫ی‬‫ں‬‫ی‬‫م‬ ‫ھڑوں‬‫ی‬‫ی‬‫ھ‬‫ب‬-‫کے‬ ‫ھڑوں‬‫ی‬‫ی‬‫ھ‬‫ب‬Lymph nodes‫رورش‬‫ٹ‬ ‫ہ‬‫ی‬‫ں‬‫ی‬‫م‬
‫ے‬‫اہ‬‫ای‬‫ی‬-‫ے‬‫ہ‬‫ا‬‫ی‬‫ب‬‫د‬‫ا‬‫ھ‬‫ڑ‬‫ٹ‬ ‫کو‬ ‫ان‬ ‫اور‬-‫کو‬ ‫س‬‫ج‬Ghon’s complex‫ں‬‫ی‬‫ہ‬ ‫ے‬‫ت‬‫ہ‬‫ک‬-
Secondary:‫ک‬‫ی‬‫ب‬‫ر‬‫ٹ‬ ‫اس‬ ‫و‬‫ہ‬‫ن‬‫کش‬‫ی‬‫ف‬‫ی‬‫ا‬‫مری‬‫ئ‬‫ا‬‫ر‬‫ٹ‬‫کو‬ ‫س‬‫ج‬‫ص‬‫خ‬‫ش‬‫ا‬‫س‬‫ی‬‫ا‬‫ہ‬‫ی‬‫و‬‫ب‬‫وں‬‫ہ‬ ‫آور‬‫ملہ‬‫ح‬ ‫ارہ‬‫دوی‬‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬
Secondary‫ے‬‫ہ‬ ‫ا‬‫ی‬‫ر‬‫ک‬ ‫ا‬‫د‬‫ی‬‫ب‬‫ن‬‫کش‬‫ی‬‫ف‬‫ی‬‫ا‬-‫ی‬‫ن‬‫ع‬‫ی‬‫سے‬ ‫ہ‬‫وج‬‫سی‬‫ک‬ ‫ھر‬‫ب‬‫ا‬‫ی‬‫ہ‬‫وج‬ ‫کی‬ ‫می‬‫ک‬ ‫کی‬ ‫ت‬‫ع‬‫ف‬‫ا‬‫د‬‫م‬‫وت‬‫ق‬
‫ی‬‫ہ‬‫وکس‬‫ق‬‫مری‬‫ئ‬‫ا‬‫ر‬‫ٹ‬‫سے‬Active‫ے‬‫ہ‬‫ا‬‫ای‬‫خ‬‫و‬‫ہ‬-‫ے‬‫ہ‬‫ا‬‫ی‬‫ی‬‫ب‬ ‫م‬‫ح‬‫ز‬‫ا‬‫ڑ‬‫ٹ‬‫و‬‫ج‬‫سے‬‫ہ‬‫وج‬ ‫کی‬ ‫اس‬-‫اسے‬
caseation‫ں‬‫ی‬‫ہ‬‫ے‬‫ت‬‫ہ‬‫ک‬-‫و‬‫ج‬Granuloma‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫در‬‫ای‬ ‫کے‬-‫س‬‫ج‬ ‫ی‬‫ت‬ ‫ی‬‫ت‬‫کے‬‫م‬
‫ے‬‫ہ‬ ‫ی‬‫ن‬‫ک‬‫ش‬‫کر‬ ‫ر‬‫اٹ‬‫ی‬‫م‬‫کو‬ ‫ے‬
ّ
‫ص‬‫خ‬ ‫ھی‬‫ب‬‫سی‬‫ک‬-
Mycobacteria
‫لی‬‫ھ‬‫ح‬‫کی‬ ‫اغ‬‫م‬‫د‬،‫ی‬‫ت‬ ‫ی‬‫ت‬ ‫کی‬ ‫ھڑوں‬‫ی‬‫ی‬‫ھ‬‫ب‬‫ں‬‫ی‬‫م‬‫س‬‫ق‬ ‫ہور‬‫ش‬‫م‬‫گر‬‫م‬‫ں‬‫ی‬‫ہ‬ ‫ل‬‫م‬‫ا‬‫ش‬ ‫رہ‬‫ی‬‫وغ‬‫ی‬‫ت‬ ‫ی‬‫ت‬ ‫کی‬-
‫ب‬‫ھی‬‫ب‬‫ی‬‫ت‬ ‫ی‬‫ت‬ ‫کی‬ ‫وں‬‫ٹ‬‫ب‬‫آ‬،‫ی‬‫ت‬ ‫ی‬‫ت‬ ‫کی‬ ‫وں‬‫ب‬‫ڈ‬‫ہ‬‫الوہ‬‫ع‬ ‫کے‬ ‫اس‬‫ں‬‫ی‬‫ہ‬‫اں‬‫اری‬‫م‬‫ی‬‫ب‬‫ام‬‫ع‬‫ت‬‫ہ‬-
ANTIBIOTIC SENSITIVITY ‫ت‬‫سی‬‫ا‬‫س‬‫ج‬‫سے‬‫ک‬‫ی‬‫و‬‫اب‬‫ی‬‫ی‬‫ن‬‫ب‬‫ا‬
‫ں‬‫ی‬‫ہ‬ ‫ی‬‫وت‬‫ہ‬‫ال‬‫م‬‫ع‬‫ت‬‫س‬‫ا‬ ‫اں‬‫ی‬‫ب‬‫دوا‬ ‫و‬‫ج‬‫ا‬‫م‬‫مو‬‫ع‬-‫ں‬‫ی‬‫م‬ ‫ان‬isoniazid, Rifampin‫ل‬‫م‬‫ا‬‫ش‬
‫ں‬‫ی‬‫ہ‬-‫ے‬‫ہ‬ ‫ی‬‫وت‬‫ہ‬‫ی‬‫اق‬‫ک‬ ‫ہ‬‫ی‬ ‫ی‬‫دوات‬‫ک‬‫ی‬‫ا‬‫ے‬‫ت‬‫ل‬ ‫کے‬‫الج‬‫ع‬‫ا‬‫م‬‫مو‬‫ع‬-‫اس‬‫کے‬‫ال‬‫م‬ ‫اں‬‫ی‬‫ب‬‫دوا‬‫ے‬‫ت‬‫ل‬
‫ں‬‫ی‬‫ہ‬ ‫ی‬‫ات‬‫خ‬‫دی‬-
MYCOBACTERIUM LEPRAE
‫ی‬‫ر‬‫ک‬ ‫ا‬‫د‬‫ی‬‫ب‬‫اری‬‫م‬‫ی‬‫ب‬ ‫کی‬ ‫سی‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ل‬‫ا‬‫ی‬‫کوڑھ‬ ‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ہ‬‫ی‬‫ے‬‫ہ‬‫ا‬-‫کو‬ ‫اس‬Grow‫سی‬‫ک‬ ‫ے‬‫ت‬‫ل‬ ‫کے‬‫ے‬‫کرت‬
‫ے‬‫ہ‬ ‫ا‬‫ڑی‬‫ٹ‬‫ا‬‫ی‬‫ر‬‫ک‬ ‫ل‬‫خ‬‫دا‬‫در‬‫ای‬‫کے‬ ‫ور‬‫اب‬‫خ‬-‫ٹ‬ ‫م‬‫ی‬‫ڈ‬‫ی‬‫م‬‫سی‬‫ک‬ ‫ہ‬‫ی‬‫ر‬‫وگ‬‫ں‬‫ی‬‫م‬‫ری‬‫ارٹ‬‫ی‬‫ی‬‫ل‬‫ر‬Grow‫ں‬‫ی‬‫ہ‬‫ب‬
‫اری‬‫م‬‫ی‬‫ب‬‫ہ‬‫ی‬ ‫ا‬‫ی‬‫ک‬‫ش‬‫و‬‫ہ‬nerve‫اور‬skin‫ے‬‫ہ‬ ‫ی‬‫ت‬‫ر‬‫ک‬ ‫ر‬‫اٹ‬‫ی‬‫م‬‫کو‬-‫کی‬ ‫ھوت‬‫ح‬‫ہ‬‫ی‬‫ں‬‫ی‬‫ہ‬‫ب‬‫اری‬‫م‬‫ی‬‫ب‬
‫م‬‫الج‬‫ع‬‫ل‬‫ی‬‫ا‬‫ق‬ ‫اور‬‫ا‬‫ھ‬‫ب‬ ‫ا‬‫ای‬‫خ‬‫ا‬‫ھ‬‫ج‬‫م‬‫س‬‫ں‬‫ی‬‫م‬‫وں‬‫اب‬‫م‬‫ز‬‫لے‬‫ہ‬‫ب‬ ‫کہ‬ ‫ا‬‫س‬‫ی‬‫ج‬‫ے‬‫ہ‬ ‫رض‬-
Mycobacteria

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Microbiology of Air, Water and Soil
Microbiology of Air, Water and SoilMicrobiology of Air, Water and Soil
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Culture media
Culture mediaCulture media
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Bacterial Culture
Bacterial CultureBacterial Culture
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An Overview of Immunity to Viruses, Bacteria, Fungi and Ptozoans
An Overview of Immunity to Viruses, Bacteria, Fungi and PtozoansAn Overview of Immunity to Viruses, Bacteria, Fungi and Ptozoans
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An Overview of the Immune System
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Major Histocompatibility Complex (MHC)
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Factor affecting bacterial growth
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Cellular and molecular basis of immunity
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Natural and Artificial immunity
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Nutrition Requirement of Bacteria
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Nomenclature and classification of microorganisms
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Mycobacteria

  • 2. ‫اس‬Genus‫ں‬‫ی‬‫ہ‬ ‫ل‬‫م‬‫ا‬‫ش‬‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫و‬‫ج‬‫ں‬‫ی‬‫م‬-‫ہ‬‫طرح‬ ‫کی‬ ‫راڈز‬ ‫وو‬‫ں‬‫ی‬‫ہ‬ ‫ے‬‫وت‬-‫ھی‬‫ب‬‫کو‬ ‫سڈ‬‫ی‬‫ا‬ ‫ں‬‫ی‬‫ہ‬ ‫ے‬‫وت‬‫ہ‬‫م‬‫ح‬‫ا‬‫ز‬‫م‬–‫ی‬‫ن‬‫ع‬‫ی‬Acid fast‫ں‬‫ی‬‫ہ‬ ‫ے‬‫وت‬‫ہ‬-‫اری‬‫م‬‫ی‬‫ب‬‫اری‬‫ش‬‫ت‬‫ہ‬‫ب‬‫اور‬‫ا‬‫د‬‫ی‬‫ب‬‫اں‬ ‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬-  Mycobacterium Tuberculosis  Mycobacterium bovis  Mycobacterium Leprae  Atypical Mycobacterium • M. kansasii • M. marinum • M. avium-intracellulare complex • M. fortuitum-chelonei complex
  • 3. MYCOBACTERIUM TUBERCULOSIS ‫ے‬‫ہ‬ ‫زم‬‫ارگی‬‫و‬‫ٹ‬‫ب‬‫از‬‫ی‬‫ام‬‫ر‬‫گ‬ ‫ا‬‫ک‬ ‫ل‬‫ک‬‫ش‬ ‫کی‬ ‫راڈ‬ ‫ہ‬‫ی‬-‫کے‬‫و‬‫ج‬Ziehl–Neelsen stain ‫ی‬‫ن‬‫ع‬‫ی‬Z.N‫ں‬‫ی‬‫ہ‬‫ے‬‫ت‬‫ی‬‫ل‬ ‫گ‬‫ی‬‫ر‬ ‫سرخ‬‫سے‬‫ن‬‫ی‬‫ٹ‬‫س‬-‫ب‬‫سے‬‫سڈ‬‫ی‬‫ا‬ ‫اور‬‫ے‬‫کرت‬ ‫ت‬‫م‬‫ح‬‫ا‬‫ز‬‫م‬ ‫ھی‬‫ں‬‫ی‬‫ہ‬ ‫اور‬‫ے‬‫ت‬‫ے‬‫وت‬‫ہ‬‫ں‬‫ی‬‫ہ‬‫ب‬‫گ‬‫ی‬‫ر‬-‫ہ‬‫ی‬ ‫ے‬‫ت‬‫ل‬ ‫اس‬Smear‫ر‬‫ظ‬‫ی‬ ‫راڈ‬ ‫کی‬ ‫گ‬‫ی‬‫ر‬ ‫سرخ‬‫ں‬‫ی‬‫م‬‫ی‬‫آت‬ ‫ے‬‫ہ‬-‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫ا‬‫ک‬ ‫گ‬‫ی‬‫ر‬‫لے‬‫ی‬‫ب‬ ‫ڈ‬‫اؤی‬‫ر‬‫گ‬ ‫ک‬‫ی‬‫ب‬‫ی‬‫اق‬‫ی‬‫کے‬‫ی‬‫ج‬- 
  • 4. CULTURAL CHARACTERISTICS ‫ات‬‫ی‬‫ص‬‫صو‬‫خ‬‫کی‬ ‫ر‬‫چ‬‫ل‬‫ک‬ ‫ں‬‫ی‬‫م‬‫ری‬‫ارٹ‬‫ی‬‫ی‬‫ل‬ ‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ہ‬‫ی‬Grow‫ے‬‫ہ‬‫ام‬‫ک‬ ‫ل‬‫ک‬‫ش‬‫م‬‫ا‬‫ی‬‫ر‬‫ک‬-‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ام‬‫ع‬ ‫ہ‬‫ی‬‫ت‬‫ق‬‫و‬‫د‬‫زای‬‫سے‬‫ا‬ ‫ے‬‫ہ‬ ‫ا‬‫ی‬‫ی‬‫ل‬-‫ا‬‫ل‬‫م‬‫ع‬‫ا‬‫ک‬ ‫ے‬‫ت‬‫ی‬‫ب‬ ‫دو‬‫سے‬‫ک‬‫ی‬‫ا‬‫کہ‬ ‫ے‬‫ہ‬ ‫ہ‬‫ی‬‫ہ‬‫وج‬ ‫کی‬ ‫اس‬‫ت‬‫ہ‬‫ب‬‫ں‬‫ی‬‫م‬ ‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫س‬ ‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫ت‬‫س‬‫س‬- ً ‫ا‬‫ی‬‫ب‬‫ر‬‫ق‬‫ی‬ ‫اور‬18‫ں‬‫ی‬‫ہ‬ ‫ے‬‫ت‬‫گ‬‫ل‬‫ے‬‫ت‬‫ی‬‫ھ‬‫گ‬-Mycobacterium‫ے‬‫ت‬‫ل‬ ‫کے‬ ‫م‬‫اصی‬‫خ‬‫ھی‬‫ح‬‫ا‬‫ن‬‫ی‬‫ب‬‫رو‬‫ٹ‬‫ں‬‫ی‬‫م‬‫س‬‫ج‬‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫ار‬‫ک‬‫در‬ ‫م‬‫ی‬‫ڈ‬‫ی‬‫م‬ ‫ا‬‫س‬‫ی‬‫ا‬‫و‬‫ہ‬‫ود‬‫موج‬‫ں‬‫ی‬‫م‬‫ار‬‫د‬‫ق‬- ً ‫ال‬‫ی‬‫م‬ ‫ن‬‫ی‬‫ب‬‫رو‬‫ٹ‬ ‫کی‬ ‫ڈے‬‫ای‬-‫ل‬ ‫کے‬‫ری‬‫ڑھوٹ‬‫ٹ‬ ‫ے‬‫ت‬‫ب‬ ‫ا‬‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ہ‬‫ی‬‫سوس‬‫ح‬‫م‬‫رورت‬‫ض‬ ‫کی‬ ‫ن‬‫ج‬‫ی‬‫س‬‫ک‬‫آ‬‫ے‬‫ت‬ ‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬- ‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫ال‬‫م‬‫ع‬‫ت‬‫س‬‫ا‬‫ر‬‫ٹ‬ ‫طور‬‫ام‬‫ع‬ ‫م‬‫ی‬‫ڈ‬‫ی‬‫م‬‫و‬‫ج‬ ‫ے‬‫ت‬‫ل‬ ‫کے‬ ‫صد‬‫ق‬‫م‬‫اس‬-‫ام‬‫ی‬‫ا‬‫ک‬ ‫اس‬ Lowenstein-Jensen (LJ) medium‫ے‬‫ہ‬-‫الون‬‫ک‬ ‫ر‬‫ٹ‬ ‫م‬‫ی‬‫ڈ‬‫ی‬‫م‬ ‫اس‬‫ز‬‫ی‬ ‫ں‬‫ی‬‫ہ‬ ‫ی‬‫وت‬‫ہ‬ ‫کی‬ ‫گ‬‫ی‬‫ر‬ ‫م‬‫ی‬‫کر‬ ‫ا‬‫ی‬‫د‬‫ی‬‫ف‬‫ش‬ ‫ک‬‫س‬‫ج‬ ، ‫ی‬‫وت‬‫ہ‬ ‫ھری‬‫ب‬‫ا‬-‫ک‬‫کو‬ ‫ل‬‫ی‬‫و‬‫ب‬‫ر‬‫چ‬‫ل‬6-8‫کے‬ ‫ے‬‫ت‬‫ف‬‫ہ‬ ‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬ ‫ہ‬‫ن‬‫ب‬‫ا‬‫ع‬‫م‬‫عد‬‫ی‬-
  • 6. ‫سے‬‫زی‬‫ی‬‫ن‬Grow‫ے‬‫ت‬‫ل‬ ‫کے‬‫ے‬‫کرت‬Middlebrook medium BACTEC‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬ ‫ال‬‫م‬‫ع‬‫ت‬‫س‬‫ا‬-‫ہ‬‫ج‬‫ی‬‫ی‬‫ب‬‫ں‬‫ی‬‫م‬ ‫س‬‫ج‬2‫ے‬‫ہ‬‫ا‬‫ی‬‫آ‬‫عد‬‫ی‬ ‫ے‬‫ت‬‫ف‬‫ہ‬-
  • 7. PATHOGENICITY ‫اں‬‫اری‬‫م‬‫ی‬‫ب‬ Mycobacterium tuberculosis‫اور‬Mycobacterium leprae‫وں‬‫اب‬‫س‬‫ی‬‫ا‬‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬ ‫ا‬‫د‬‫ی‬‫ب‬‫اں‬‫اری‬‫م‬‫ی‬‫ب‬‫ں‬‫ی‬‫م‬-‫اور‬TB‫ں‬‫ی‬‫ہ‬‫ے‬‫کرت‬ ‫ا‬‫د‬‫ی‬‫ب‬–‫دو‬‫ہ‬‫ی‬ ‫ے‬‫ہ‬ ‫ی‬‫وت‬‫ہ‬‫کی‬ ‫م‬‫س‬‫ق‬- Primary:‫م‬‫م‬‫س‬‫ج‬ ‫ہ‬‫ن‬‫ب‬‫ر‬‫م‬ ‫لی‬‫ہ‬‫ب‬ ‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ں‬‫ی‬‫م‬‫اری‬‫م‬‫ی‬‫ب‬ ‫اس‬‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬ ‫ل‬‫خ‬‫دا‬‫ں‬‫ی‬-‫اور‬ ‫ے‬‫ہ‬‫ا‬‫ی‬‫ہ‬‫ر‬ ‫ا‬‫ی‬‫ھ‬‫ڑ‬‫ٹ‬ ‫ہ‬‫ی‬‫ں‬‫ی‬‫م‬ ‫ھڑوں‬‫ی‬‫ی‬‫ھ‬‫ب‬-‫کے‬ ‫ھڑوں‬‫ی‬‫ی‬‫ھ‬‫ب‬Lymph nodes‫رورش‬‫ٹ‬ ‫ہ‬‫ی‬‫ں‬‫ی‬‫م‬ ‫ے‬‫اہ‬‫ای‬‫ی‬-‫ے‬‫ہ‬‫ا‬‫ی‬‫ب‬‫د‬‫ا‬‫ھ‬‫ڑ‬‫ٹ‬ ‫کو‬ ‫ان‬ ‫اور‬-‫کو‬ ‫س‬‫ج‬Ghon’s complex‫ں‬‫ی‬‫ہ‬ ‫ے‬‫ت‬‫ہ‬‫ک‬- Secondary:‫ک‬‫ی‬‫ب‬‫ر‬‫ٹ‬ ‫اس‬ ‫و‬‫ہ‬‫ن‬‫کش‬‫ی‬‫ف‬‫ی‬‫ا‬‫مری‬‫ئ‬‫ا‬‫ر‬‫ٹ‬‫کو‬ ‫س‬‫ج‬‫ص‬‫خ‬‫ش‬‫ا‬‫س‬‫ی‬‫ا‬‫ہ‬‫ی‬‫و‬‫ب‬‫وں‬‫ہ‬ ‫آور‬‫ملہ‬‫ح‬ ‫ارہ‬‫دوی‬‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬ Secondary‫ے‬‫ہ‬ ‫ا‬‫ی‬‫ر‬‫ک‬ ‫ا‬‫د‬‫ی‬‫ب‬‫ن‬‫کش‬‫ی‬‫ف‬‫ی‬‫ا‬-‫ی‬‫ن‬‫ع‬‫ی‬‫سے‬ ‫ہ‬‫وج‬‫سی‬‫ک‬ ‫ھر‬‫ب‬‫ا‬‫ی‬‫ہ‬‫وج‬ ‫کی‬ ‫می‬‫ک‬ ‫کی‬ ‫ت‬‫ع‬‫ف‬‫ا‬‫د‬‫م‬‫وت‬‫ق‬ ‫ی‬‫ہ‬‫وکس‬‫ق‬‫مری‬‫ئ‬‫ا‬‫ر‬‫ٹ‬‫سے‬Active‫ے‬‫ہ‬‫ا‬‫ای‬‫خ‬‫و‬‫ہ‬-‫ے‬‫ہ‬‫ا‬‫ی‬‫ی‬‫ب‬ ‫م‬‫ح‬‫ز‬‫ا‬‫ڑ‬‫ٹ‬‫و‬‫ج‬‫سے‬‫ہ‬‫وج‬ ‫کی‬ ‫اس‬-‫اسے‬ caseation‫ں‬‫ی‬‫ہ‬‫ے‬‫ت‬‫ہ‬‫ک‬-‫و‬‫ج‬Granuloma‫ے‬‫ہ‬‫ا‬‫وی‬‫ہ‬‫در‬‫ای‬ ‫کے‬-‫س‬‫ج‬ ‫ی‬‫ت‬ ‫ی‬‫ت‬‫کے‬‫م‬ ‫ے‬‫ہ‬ ‫ی‬‫ن‬‫ک‬‫ش‬‫کر‬ ‫ر‬‫اٹ‬‫ی‬‫م‬‫کو‬ ‫ے‬ ّ ‫ص‬‫خ‬ ‫ھی‬‫ب‬‫سی‬‫ک‬-
  • 9. ‫لی‬‫ھ‬‫ح‬‫کی‬ ‫اغ‬‫م‬‫د‬،‫ی‬‫ت‬ ‫ی‬‫ت‬ ‫کی‬ ‫ھڑوں‬‫ی‬‫ی‬‫ھ‬‫ب‬‫ں‬‫ی‬‫م‬‫س‬‫ق‬ ‫ہور‬‫ش‬‫م‬‫گر‬‫م‬‫ں‬‫ی‬‫ہ‬ ‫ل‬‫م‬‫ا‬‫ش‬ ‫رہ‬‫ی‬‫وغ‬‫ی‬‫ت‬ ‫ی‬‫ت‬ ‫کی‬- ‫ب‬‫ھی‬‫ب‬‫ی‬‫ت‬ ‫ی‬‫ت‬ ‫کی‬ ‫وں‬‫ٹ‬‫ب‬‫آ‬،‫ی‬‫ت‬ ‫ی‬‫ت‬ ‫کی‬ ‫وں‬‫ب‬‫ڈ‬‫ہ‬‫الوہ‬‫ع‬ ‫کے‬ ‫اس‬‫ں‬‫ی‬‫ہ‬‫اں‬‫اری‬‫م‬‫ی‬‫ب‬‫ام‬‫ع‬‫ت‬‫ہ‬-
  • 10. ANTIBIOTIC SENSITIVITY ‫ت‬‫سی‬‫ا‬‫س‬‫ج‬‫سے‬‫ک‬‫ی‬‫و‬‫اب‬‫ی‬‫ی‬‫ن‬‫ب‬‫ا‬ ‫ں‬‫ی‬‫ہ‬ ‫ی‬‫وت‬‫ہ‬‫ال‬‫م‬‫ع‬‫ت‬‫س‬‫ا‬ ‫اں‬‫ی‬‫ب‬‫دوا‬ ‫و‬‫ج‬‫ا‬‫م‬‫مو‬‫ع‬-‫ں‬‫ی‬‫م‬ ‫ان‬isoniazid, Rifampin‫ل‬‫م‬‫ا‬‫ش‬ ‫ں‬‫ی‬‫ہ‬-‫ے‬‫ہ‬ ‫ی‬‫وت‬‫ہ‬‫ی‬‫اق‬‫ک‬ ‫ہ‬‫ی‬ ‫ی‬‫دوات‬‫ک‬‫ی‬‫ا‬‫ے‬‫ت‬‫ل‬ ‫کے‬‫الج‬‫ع‬‫ا‬‫م‬‫مو‬‫ع‬-‫اس‬‫کے‬‫ال‬‫م‬ ‫اں‬‫ی‬‫ب‬‫دوا‬‫ے‬‫ت‬‫ل‬ ‫ں‬‫ی‬‫ہ‬ ‫ی‬‫ات‬‫خ‬‫دی‬-
  • 11. MYCOBACTERIUM LEPRAE ‫ی‬‫ر‬‫ک‬ ‫ا‬‫د‬‫ی‬‫ب‬‫اری‬‫م‬‫ی‬‫ب‬ ‫کی‬ ‫سی‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ل‬‫ا‬‫ی‬‫کوڑھ‬ ‫ا‬‫ی‬‫ر‬‫ی‬‫ٹ‬‫ک‬‫ی‬‫ب‬‫ہ‬‫ی‬‫ے‬‫ہ‬‫ا‬-‫کو‬ ‫اس‬Grow‫سی‬‫ک‬ ‫ے‬‫ت‬‫ل‬ ‫کے‬‫ے‬‫کرت‬ ‫ے‬‫ہ‬ ‫ا‬‫ڑی‬‫ٹ‬‫ا‬‫ی‬‫ر‬‫ک‬ ‫ل‬‫خ‬‫دا‬‫در‬‫ای‬‫کے‬ ‫ور‬‫اب‬‫خ‬-‫ٹ‬ ‫م‬‫ی‬‫ڈ‬‫ی‬‫م‬‫سی‬‫ک‬ ‫ہ‬‫ی‬‫ر‬‫وگ‬‫ں‬‫ی‬‫م‬‫ری‬‫ارٹ‬‫ی‬‫ی‬‫ل‬‫ر‬Grow‫ں‬‫ی‬‫ہ‬‫ب‬ ‫اری‬‫م‬‫ی‬‫ب‬‫ہ‬‫ی‬ ‫ا‬‫ی‬‫ک‬‫ش‬‫و‬‫ہ‬nerve‫اور‬skin‫ے‬‫ہ‬ ‫ی‬‫ت‬‫ر‬‫ک‬ ‫ر‬‫اٹ‬‫ی‬‫م‬‫کو‬-‫کی‬ ‫ھوت‬‫ح‬‫ہ‬‫ی‬‫ں‬‫ی‬‫ہ‬‫ب‬‫اری‬‫م‬‫ی‬‫ب‬ ‫م‬‫الج‬‫ع‬‫ل‬‫ی‬‫ا‬‫ق‬ ‫اور‬‫ا‬‫ھ‬‫ب‬ ‫ا‬‫ای‬‫خ‬‫ا‬‫ھ‬‫ج‬‫م‬‫س‬‫ں‬‫ی‬‫م‬‫وں‬‫اب‬‫م‬‫ز‬‫لے‬‫ہ‬‫ب‬ ‫کہ‬ ‫ا‬‫س‬‫ی‬‫ج‬‫ے‬‫ہ‬ ‫رض‬-