Acute leukaemias classification

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Acute leukaemias classification

  1. 1. Acute Leukaemias CLASSIFICATION
  2. 2. French American British (FAB)  Morphological classification  Degree of maturation  Lineage of the leukaemic blasts  Histochemical stains  Immunostains
  3. 3. AML M0 Minimal Differentiation  No evidence of myeloid differentiation by morphology and light microscopy.  Immunological markers are required.  <5%.  Any age but most common in infants and older adults.
  4. 4.  Medium sized blast cells with dispersed chromatin.  Round to indented nuclei.  1 or 2 nucleoli.  Agranular cytoplasm  <3% are SBB/MPO +  CD34,CD33, HLA-DR +
  5. 5. AML M 1 Without Maturation  >90% blast cells without significant evidence of maturation to more mature neutrophils.  5- 10%  Any age usually adults  SBB/MPO >3%  Auer Rods
  6. 6. AML M2 With Maturation  >20% blasts with evidence of maturation (>10% maturing cells of neutrophil lineage).  Auer Rods  t(8;21)  10%  Any age
  7. 7. AML M3 Acute Promyelocytic Leukaemia  Abnormal Promyelocyte predominate  Hypergranular or Typical APL.  Microgranular (hypogranular) Type.  Young Adults, 5- 10%  Auer Rods (Faggot cells)  DIC  t(15;17)
  8. 8. AML M4 Acute Myelomonocytic Leukaemia  Myelocytic and Monocytic differentiation.  Myeloid maturation  Older individuals  5- 10%  Inv16  Monoblasts are nonspecific esterases +  Myeloblast SBB +
  9. 9. AML M 5 Acute Monocytic Leukaemia  80% or more of the leukaemic cells are monocytic lineage ( monoblasts, promonocytes and monocytes)  10%  Older age  Organ involvement (CNS, Gum hyperplasia, Skin)  Nonspecific easterase +
  10. 10. AML M6 Acute Erythroleukaemia  Dyplastic erythroid precursors  >50% erythroid precursors in the entire nucleated cell population and >20% myeloblasts in the non-erythroid cell population.  <5%  Therapy related  SBB/MPO -
  11. 11. AML M7 Acute Megakaryoblastic Leukaemia  20% blasts of which at least 50% are of megakaryocyte lineage  Uncommon  Cytopenias often thrombocytopenia  SBB –  Immunostains  Myelofibrosis

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