Chapter 8             Medication for            Mental Disorders© 2011 McGraw-Hill Higher Education. All rights reserved.
Mental Disorders:                                                 The Medical Model          Model: symptoms             ...
Classification of Mental                                             Disorders          APA Diagnostic and Statistical Ma...
Mental Disorders          Anxiety disorders—characterized by                 excessive worry, fears, or avoidance        ...
Mental Disorders          Psychosis—a serious mental disorder involving           loss of contact with reality          ...
Mental Disorders          Mood disorders—                 characterized by depressed                 or manic symptoms   ...
Early Treatment of Mental                                      Disorders          Syphilitic infection and malaria       ...
Early Treatment of Mental                                      Disorders          Early drug therapy                    ...
Antipsychotics: Discovery of                              Phenothiazines          Called tranquilizers, neuroleptics, or ...
Antipsychotics: Treatment                                   Considerations          Treatment with phenothiazines found t...
Antipsychotics:                                         Mechanisms of Action          Antipsychotics produce           ps...
Antipsychotics: Side Effects          Safe in that they are not addictive and are                 difficult to use to com...
Antipsychotics: Long-term                                           Effectiveness          Even patients experiencing suc...
Antidepressants: Major Types          Monoamine oxidase (MAO)                 inhibitors                   Examples: phe...
Monoamine Oxidase Inhibitors          Discovered when a drug for tuberculosis           was found to also elevate mood   ...
Tricyclic Antidepressants          Discovered when researchers were working to                 create a better phenothiaz...
Selective Serotonin Reuptake                              Inhibitors          SSRIs may work by reducing the uptake (and ...
Antidepressants:                                            Mechanism of Action          Appear to work by increasing the...
Electroconvulsive Therapy          Most effective treatment for relieving           severe depression          Works ver...
Mood Stabilizers          Lithium: Approved for U.S. sale in 1970                    Early studies found it to be effect...
Mood Stabilizers          Lithium                    Normalizes mood in bipolar patients,                          preve...
Consequences of Drug                                 Treatment for Mental Illness          Number of people in mental hos...
Number of Patients in Nonfederal                               Psychiatric Hospitals                          •In 2008, th...
Consequences of Drug                                  Treatment for Mental Illness          Changes for psychiatrists    ...
Consequences of Drug                                     Treatment for Mental Illness          Civil rights issues relati...
Consequences of Drug                                   Treatment for Mental Illness          From hospital to jail or the...
Chapter 8              Medication for             Mental Disorders© 2011 McGraw-Hill Higher Education. All rights reserved.
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  • Image sources: Comstock Images/PictureQuest (Image Ch08_01MedicineCabinet); Mel Curtis/Getty Images (Image Ch08_07Depression)
  • Image source: Digital Vision / Getty Image (Image Ch08_02MentalIllness)
  • Image source: Royalty-Free/Corbis (Image Ch08_03Anxiety)
  • Image source: The McGraw-Hill Companies, Inc./Lars A. Niki, photographer (Image Ch08_04Schizophrenia)
  • Image source: Royalty-Free/Corbis (Image Ch08_05Depression)
  • Image source: Library of Congress Prints and Photographs Division (Image Ch08_06SyphilisMental)
  • Image source: Royalty-Free/Corbis (Image Ch08_11PrescriptionPills)
  • Figure 8.1 from text
  • Image source: Royalty-Free/Corbis (Image Ch08_08Psychiatrist) Image source: Tracy Montana/PhotoLink/Getty Image (Image Ch08_12PrescriptionPills)
  • Image source (prison): BrandX Pictures (Image Ch08_09Prison) Image source (homeless): The McGraw-Hill Companies, Inc./Christopher Kerrigan, photographer (Image Ch08_10Homeless)
  • Image sources: Comstock Images/PictureQuest (Image Ch08_01MedicineCabinet); Mel Curtis/Getty Images (Image Ch08_07Depression)
  • Hart13 ppt ch08

    1. 1. Chapter 8 Medication for Mental Disorders© 2011 McGraw-Hill Higher Education. All rights reserved.
    2. 2. Mental Disorders: The Medical Model  Model: symptoms diagnosis determination of cause treatment cure  Criticisms of model:  Usually the only symptoms of mental disorders are behavioral  Behaviors are varied and can have many causes  Model guides much of current thinking  Psychoactive drugs are used to control symptoms of mental illness  Researchers seek to identify chemical imbalances associated with specific mental disorders© 2011 McGraw-Hill Higher Education. All rights reserved.
    3. 3. Classification of Mental Disorders  APA Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) provides criteria for classifying mental disorders  Includes hundreds of specific diagnostic categories  Widely used classification system© 2011 McGraw-Hill Higher Education. All rights reserved.
    4. 4. Mental Disorders  Anxiety disorders—characterized by excessive worry, fears, or avoidance  Panic disorder  Specific phobia  Social phobia  Obsessive-compulsive disorder  Posttraumatic stress disorder  Generalized anxiety disorder© 2011 McGraw-Hill Higher Education. All rights reserved.
    5. 5. Mental Disorders  Psychosis—a serious mental disorder involving loss of contact with reality  Schizophrenia—chronic psychosis characterized by delusions, hallucinations, disorganized speech and behavior, and lack of emotional response; causes significant interference with social and/or occupational functioning© 2011 McGraw-Hill Higher Education. All rights reserved.
    6. 6. Mental Disorders  Mood disorders— characterized by depressed or manic symptoms  Major depression  Manic episodes  Bipolar disorder  Symptoms don’t always fit neatly into diagnostic categories© 2011 McGraw-Hill Higher Education. All rights reserved.
    7. 7. Early Treatment of Mental Disorders  Syphilitic infection and malaria therapy  In the early twentieth century, many psychotic patients were suffering from syphilitic infection of the nervous system (general paresis)  Fever associated with malaria was thought to improve the condition  Antibiotics were developed that cured syphilis© 2011 McGraw-Hill Higher Education. All rights reserved.
    8. 8. Early Treatment of Mental Disorders  Early drug therapy  Narcosis therapy: depressants used to induce sleep  Intravenous thiopental sodium (“truth serum”) used during psychotherapy to help patients express themselves  Insulin-shock therapy  Electroconvulsive therapy: it was incorrectly believed that inducing convulsions with drugs or electric shocks would cure schizophrenia  Sedatives used in severely disturbed patients© 2011 McGraw-Hill Higher Education. All rights reserved.
    9. 9. Antipsychotics: Discovery of Phenothiazines  Called tranquilizers, neuroleptics, or antipsychotics  Reduce psychotic symptoms without causing sedation  Following introduction of drug therapy, restraints and treatments like convulsive therapy were reduced or discontinued among hospitalized patients© 2011 McGraw-Hill Higher Education. All rights reserved.
    10. 10. Antipsychotics: Treatment Considerations  Treatment with phenothiazines found to be more effective than a placebo  Patients relapse when therapy is discontinued  Two groups of antipsychotics  Conventional (introduced before mid-1990s)  Atypical (introduced in the past 10 years)© 2011 McGraw-Hill Higher Education. All rights reserved.
    11. 11. Antipsychotics: Mechanisms of Action  Antipsychotics produce pseudoparkinsonism, indicating a link to dopamine receptors  Time delay in drug effects indicates that the mechanism of action is probably more complex  Atypical antipsychotics block both D2 dopamine and 5HT2A serotonin receptors  Produce less pseudoparkinsonism© 2011 McGraw-Hill Higher Education. All rights reserved.
    12. 12. Antipsychotics: Side Effects  Safe in that they are not addictive and are difficult to use to commit suicide  Side effects  Some allergic reactions (jaundice, skin rashes)  Photosensitivity (easily sunburned)  Agranulocytosis (low white blood cell count)  Movement disorders (tremors, muscle rigidity, shuffling walk, masklike face)  Tardive dyskinesia© 2011 McGraw-Hill Higher Education. All rights reserved.
    13. 13. Antipsychotics: Long-term Effectiveness  Even patients experiencing success tend to stop taking the drug  Short-term efficacy exists, but long-term appears to be considerably lower  No clear evidence that atypical antipsychotics work better than conventional  When used in children there is a high risk of weight gain and metabolic changes  Elderly patients with dementia have a significant increase in death risk from cardiovascular and other problems.© 2011 McGraw-Hill Higher Education. All rights reserved.
    14. 14. Antidepressants: Major Types  Monoamine oxidase (MAO) inhibitors  Examples: phenelzine, tranylcypromine  Tricyclic antidepressants  Examples: amitriptyline, doxepin, nortriptyline  Selective serotonin reuptake inhibitors (SSRIs)  Examples: fluoxetine, sertraline, venlafaxine© 2011 McGraw-Hill Higher Education. All rights reserved.
    15. 15. Monoamine Oxidase Inhibitors  Discovered when a drug for tuberculosis was found to also elevate mood  Work by increasing the availability of serotonin, norepinephrine, and dopamine  Limited use due to side effects and toxicity  Users must avoid certain foods and drugs to prevent severe side effects© 2011 McGraw-Hill Higher Education. All rights reserved.
    16. 16. Tricyclic Antidepressants  Discovered when researchers were working to create a better phenothiazine antipsychotic and found a drug that improved mood  May work by reducing the uptake (and thereby increasing the availability) of norepinephrine, dopamine, and serotonin  Not effective in all patients, but they reduce the severity and duration of depressive episodes© 2011 McGraw-Hill Higher Education. All rights reserved.
    17. 17. Selective Serotonin Reuptake Inhibitors  SSRIs may work by reducing the uptake (and thereby increasing the availability) of serotonin  Safer than tricyclic antidepressants, less likely to lead to overdose deaths  Only a little more effective than placebo  Strong warning from FDA about an increased risk of suicidal tendencies in children and adolescents© 2011 McGraw-Hill Higher Education. All rights reserved.
    18. 18. Antidepressants: Mechanism of Action  Appear to work by increasing the availability of norepinephrine or serotonin  A lag period before improvement in mood is seen  We don’t yet have the complete picture of how antidepressants work© 2011 McGraw-Hill Higher Education. All rights reserved.
    19. 19. Electroconvulsive Therapy  Most effective treatment for relieving severe depression  Works very rapidly, more quickly than antidepressant drugs  Best treatment choice in cases with a risk of suicide  Can be used in conjunction with drugs© 2011 McGraw-Hill Higher Education. All rights reserved.
    20. 20. Mood Stabilizers  Lithium: Approved for U.S. sale in 1970  Early studies found it to be effective in manic patients  Acceptance slow in United States  Previous history of poisonings  Low perception of seriousness of mania  U.S. drug approval and sale process  Can be safe or toxic; blood levels must be monitored  High rate of patient noncompliance© 2011 McGraw-Hill Higher Education. All rights reserved.
    21. 21. Mood Stabilizers  Lithium  Normalizes mood in bipolar patients, preventing both mania and depressed mood swings  Little effect in treating unipolar depression  Other mood stabilizers are anticonvulsant drugs (valproic acid, carbamazepine, lamotrigine)© 2011 McGraw-Hill Higher Education. All rights reserved.
    22. 22. Consequences of Drug Treatment for Mental Illness  Number of people in mental hospitals declined dramatically following the introduction of drugs that control the symptoms of schizophrenia to a great degree  Outpatient community mental health programs were set up to treat patients closer to home in a more natural environment at less expense© 2011 McGraw-Hill Higher Education. All rights reserved.
    23. 23. Number of Patients in Nonfederal Psychiatric Hospitals •In 2008, the number of patients was 68,000, the same as 2004. Data source: American Hospital Association© 2011 McGraw-Hill Higher Education. All rights reserved.
    24. 24. Consequences of Drug Treatment for Mental Illness  Changes for psychiatrists  Less time spent doing psychotherapy  Priority and emphasis on establishing an appropriate drug regimen© 2011 McGraw-Hill Higher Education. All rights reserved.
    25. 25. Consequences of Drug Treatment for Mental Illness  Civil rights issues relating to hospitalization  Indefinite commitment to a hospital is unconstitutional  Periodic review of a patient’s status helps determine if patient presents a danger to self or others  Problems  Patients may have well-controlled symptoms while on medication in a hospital but may stop taking medication upon release  Unmedicated patients, although not overtly dangerous, may still be too ill to care for themselves© 2011 McGraw-Hill Higher Education. All rights reserved.
    26. 26. Consequences of Drug Treatment for Mental Illness  From hospital to jail or the street  More mentally ill persons are jailed each year than are admitted to state mental hospitals  About one-third of all homeless people have some form of serious mental illness© 2011 McGraw-Hill Higher Education. All rights reserved.
    27. 27. Chapter 8 Medication for Mental Disorders© 2011 McGraw-Hill Higher Education. All rights reserved.

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