Hormonal Agents – Prostate Cancer Medications

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Hormonal Agents – Prostate Cancer Medications

  1. 1. Hormonal Agents – Prostate Cancer Medications --Gonadotropin-Releasing Hormone Agonists (GRHA) --Androgen Receptor Blockers GRHA leuprolide (Eligard, Lupron) Others: triptorelin (Trelstar Depot) – SQ, IM stop production of testosterone Palliative Treatment 4 advanced prostate cancer Androgen Receptor Blockers flutamide (Eulexin) Others: bicalutamide (Casodex) – PO GRHA: Leuprolide Hot flushes, only transient decreased libido gynecomastia Decreased bone density increase calcium and vitamin D intake. increase bone mass with weight-bearing exercises. Arrhythmias, pulmonary edema Monitor for arrhythmias and assess breath sounds. Androgen Blocker: Flutamide Hot flushes only transient decreased libido, gynecomastia N/V/D Monitor intake and output. Hepatitis Monitor liver enzymes. Lupron Preg X Flutamide Preg D Interactions Lupron None Flutamide Warfarin

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