State of Israel
Ministry of Industry, Trade & Labor - Foreign Trade Administration
              Investment Promotion Cent...
Invest in Israel Now



 Economic Growth
 Competitive Edge
 Strong Track Record
 Developed Life Science sector
 Government...
Highlights

 Healthy Thriving Economy
 First in the world for Medical Device Patents per Capita,
 Forth for Bio-Pharma Pat...
Country ID




       Area: 22,000 sqkm
 Population: ~ 7.2 millions
       GDP: $168 Billion (2008F)
 Main Cities: Jerusal...
Main Economic Indicators

                                          2005            2006           2007         2008F

GDP...
Main Economic Indicators (Graphs)

                                                Unemployment (%)
  Inflation % (excl. h...
Foreign Direct Investment
   (millions of US$)


16,000

14,000

12,000

10,000

 8,000

 6,000

 4,000

 2,000

     -
  ...
Foreign Companies Invested in Israel - Some Examples
          US                     Europe                  Asia

•     ...
Money raised by Israeli Life Science companies

                                                                          ...
Israel’s Competitive Edge – IMD World Report 2007
Country Rank                            1st          2nd          3rd   ...
Israel’s Competitive Edge – WEF Report 2007

Country Rank                                          1st              2nd   ...
Innovation - 1st in Medical 4th in Biopharma

                  Medical patents/capita                             BioPhar...
Significant Selected Mergers & Acquisitions
 Acquirer            Amount         Sector               Israeli Company     D...
Israel Life sciences cluster                                              Leading
                                        ...
Israel’s Life Sciences Industry sectors and stage

                                                 Companies by
         ...
Major Therapeutic Areas:

 CNS – Four Blockbuster drugs in market (Copaxone,
 Rebif, Exelon, Azilect)
 Additional 5 drugs ...
Major Technological Fields:

 Implantable therapeutic devices
 Diagnostics & Monitoring – Device & Biomarkers
 Therapeutic...
Israeli Biotechnology Innovations

 Can-Fite has developed a platform technology that targets the A3
 Adenosine Receptor f...
Israeli Medical Devices Breakthroughs

            Given Imaging - 1st ingestible video camera used to
          view the ...
Israeli Medical Devices Breakthroughs

 3D Endoscope
 3D Dental Mapping
 Fixed noncooled Magnet Open MRI
 Simulators for M...
Government Support
 The Law for the Encouragement of Capital Investments
    Competitive grant program
    Tax exemption p...
Summary
 Israel is a center of innovation and technological
 excellence
 Israel is a source for profit driving innovation ...
State of Israel
         Ministry of Industry, Trade & Labor
           Foreign Trade Administration
        Investment Pr...
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Israel Creating Synergies in Life Sciences

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If Life Science is your thing - have a look at what Israel has to offer

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Israel Creating Synergies in Life Sciences

  1. 1. State of Israel Ministry of Industry, Trade & Labor - Foreign Trade Administration Investment Promotion Center Invest In Israel Where Breakthroughs Happen Creating Synergies in Life Sciences
  2. 2. Invest in Israel Now Economic Growth Competitive Edge Strong Track Record Developed Life Science sector Government Support Profit Driving Breakthroughs 2
  3. 3. Highlights Healthy Thriving Economy First in the world for Medical Device Patents per Capita, Forth for Bio-Pharma Patents. Highest civilian R&D budget/GDP, Fourth in investments in Biotechnology/GDP Rated 1-3 worldwide in Medical Device area More than 13 drugs in advanced clinical trials (3rd in Europe) Largest number of scientists per capita in the world and devotes about one third of its research to the life sciences. 3
  4. 4. Country ID Area: 22,000 sqkm Population: ~ 7.2 millions GDP: $168 Billion (2008F) Main Cities: Jerusalem, Tel-Aviv, Haifa, Be’er Sheva Maps: Wikipedia
  5. 5. Main Economic Indicators 2005 2006 2007 2008F GDP (current prices, B$) 131.2 142 161.8 ~168 GDP Growth Rate (%) 5.3 5.2 5.3 ~4 GDP/Capita (Current 18,700 19,900 21,000 ~21,730 Prices) GDP/Capita (based on 29,044 30,464 31,767 - purchasing power parity) Exports (goods & 57.9 62.6 70.65 ~78 services, B$) Imports ($ billion) 57.5 61.7 73.7 ~84 Inflation (CPI, %) 2.4 -0.1 3.4 ~5 Unemployment (%) 9.0 8.4 7.5 !6 Sources: Bank of Israel, Ministry of Finance, International Monetary Fund
  6. 6. Main Economic Indicators (Graphs) Unemployment (%) Inflation % (excl. housing) 2005 2006 2007 2008 2005 2006 2007 2008F 10 6 5 8 4 6 3 4 2 1 2 0 0 -1 GDP Growth Rate Exports ($ Billion) 2005 2006 2007 2008 2005 2006 2007 2008 100 6 5 80 4 60 3 40 2 20 1 Source: Bank of Israel Data 0 0 Sources: Bank of Israel, Ministry of Finance, International Monetary Fund
  7. 7. Foreign Direct Investment (millions of US$) 16,000 14,000 12,000 10,000 8,000 6,000 4,000 2,000 - 97' 98' 99' 00' 01' 02' 03' 04' 05` 06' 07' 08F Source: Bank of Israel
  8. 8. Foreign Companies Invested in Israel - Some Examples US Europe Asia • • • Microsoft British Telecom Sony • • • Epix SAP Toyo Ink • • • AOL Time Warner Philips Medical Fuji • • • Intel Alcatel Honda • • • IBM Siemens Sumitomo Trading • • • Perrigo Cable & Wireless Nomura • • • Cisco Systems Deutsche Telekom Samsung Electronics • • • GE Healthcare Telecom Italia Daewoo • • • Lucent Generali LG Group • • • 3Com Nestle Hyundai • • • Hewlett Packard L’Oreal Acer Computers • • • Stryker Danone Macronix • • • Motorola Unilever Winbond • • • Sun Microsystems Vilmorin Hutchison Telecomm • • • Johnson & Johnson Veolia Scigen • • • Dentsply Ferring Jain Irrigation • • • Kodak MERCK Serono Sun Pharmaceutical
  9. 9. Money raised by Israeli Life Science companies 111 500 120 103 97 Number of companies 100 Foreign Direct Investment 88 86 400 82 76 75 80 300 60 ($M) 200 40 100 20 - 0 99' 00' 01' 02' 03' 04' 05` 06' Number of companies Source: IVC-Online, Jan 2007 9
  10. 10. Israel’s Competitive Edge – IMD World Report 2007 Country Rank 1st 2nd 3rd 4th Sweden Finland Japan BUSINESS EXPENDITURE ON R&D Israel TOTAL EXPENDITURE ON R&D Sweden Finland Japan Israel AS A PRECENTAGE OF GDP AVAILABILITY OF QUALIFIED Israel Singapore India Iceland ENGINEERS Netherlands VENTURE CAPITAL AVAILABILITY U.S.A Israel Denmark Singapore INFORMATION TECHNOLOGY SKILLS Iceland Israel Korea Hong FLEXABILITY & ADAPTABILITY OF Israel Iceland Ireland THE WORKFORCE Kong HIGHER EDUCATION ACHIEVEMENTS Canada Japan Israel Singapore Israel Ranks 21 Source: IMD World Competitiveness Yearbook - 2007
  11. 11. Israel’s Competitive Edge – WEF Report 2007 Country Rank 1st 2nd 3rd 4th AVAILABILITY OF SCIENTISTS AND Japan Finland India Israel ENGINEERS U.S.A Finland VENTURE CAPITAL AVAILABILITY Israel Netherlands New Germany JUDICIAL INDEPENDENCE Israel Netherlands Zealand Sweden Singapore Iceland TECHNOLOGICAL READINESS Israel QUALITY OF RESEARCH Switzerland U.S.A U.K Israel ORGANIZATIONS Israel Ranks 17 Out of 131 Countries “Israel does spectacularly well on those indicators that capture technology innovation, education, human capital and this accounts for the very rapid movement of the Israeli Economy .” (Augusto Lopez-Claros, Chief Economist, World Economic Forum, December 2006) Source: WEF – The Global Competitiveness Report 2006 – 2007
  12. 12. Innovation - 1st in Medical 4th in Biopharma Medical patents/capita BioPharma patents/capita Israel USA United States Switzerland Sweden Denmark Japan Israel Switzerland Germany Germany Sweden Belgium Canada Canada Japan Taiwan UK Denmark France Netherland Belgium United Kingdom Netherland France Italy South Korea - 50 100 150 200 - 20 40 60 80 100 120 Source: USPTO 12
  13. 13. Significant Selected Mergers & Acquisitions Acquirer Amount Sector Israeli Company Date Nobel BioCare Feb 2008 95 Mil Pharmaceutical AlphaBio BioNess 75 Mil Medical Device Ness June 2007 Boston Scientific 80 Mil Medical Device Remon June 2007 Sun Pharma 454 Mil Taro Pharmaceutical May 2007 J&J 159 Mil Colbar July 2006 BioMaterial Epix 300 Mil Predix Apr 2006 Pharmaceutical TA Associates 90 Mil Medical Lasers Alma Lasers Mar 2006 McKesson Corp 105 Mil Cardiac Imaging Medcon Jun 2005 Ferring Holdings 80 Mil Pharmaceutical Savient Mar 2005 Sources: IVC-ONLINE and other public sources
  14. 14. Israel Life sciences cluster Leading Academic Seasoned VC Institutions Community & Research University Medical, Defense Science Technology Students and Spillover Postgraduates Existing Successful Availability of Corporate Technology Life science Immigration Human R&D Infrastructure Companies Capital Technological Global Incubators Life Science Firms Veterans Hospitals and Strong Medical Centers Innovative & Government Entrepreneurial Support Culture 14
  15. 15. Israel’s Life Sciences Industry sectors and stage Companies by Service IT stage Other 2% 5% 4% Other Pharma 6% 13% Medical Seed Biotech Revenue Devices 35% 21% 34% 53% ClinicalPre-Clinical 10% 17% Companies by sector Source: ILSI Database – 2006 15
  16. 16. Major Therapeutic Areas: CNS – Four Blockbuster drugs in market (Copaxone, Rebif, Exelon, Azilect) Additional 5 drugs in clinical stages Regenerative medicine & Cell Therapy (20 active companies, 4 in clinical trials) Cancer - Cell Therapy, Monoclonal Antibodies, Small Molecules, Image Guided Technologies Inflammation & Autoimmunity Cardiovascular Infectious diseases, Vaccines 16
  17. 17. Major Technological Fields: Implantable therapeutic devices Diagnostics & Monitoring – Device & Biomarkers Therapeutic molecules External Imaging Internal Imaging Drug delivery Cell & Tissue Therapy Minimal Invasive Surgery 17
  18. 18. Israeli Biotechnology Innovations Can-Fite has developed a platform technology that targets the A3 Adenosine Receptor for treatment of cancer and autoimmune inflammatory diseases. Gamida Cell is developing unique stem cells therapeutics, based on its proprietary stem/progenitor cells expansion technologies. Rosetta Genomics is a leader in the development of microRNA- based diagnostics and therapeutics Two Israeli companies lead the quest to develop a stem cell therapy for Parkinson’s disease. BrainStorm Cell Therapeutics uses autologous bone marrow derived adult stem cells, while Cell Cure employs human embryonic stem cell technology. Both companies have had successes in reducing symptoms of Parkinson’s disease in mice or rat models and are approaching readiness for clinical trials And Biocancell, BionVax, Compugen, Nasvax … 18
  19. 19. Israeli Medical Devices Breakthroughs Given Imaging - 1st ingestible video camera used to view the small intestine and diagnose disorders Insightec - Image Guided HIFUS (High Intensity Focused Ultrasound) GE Healthcare in Israel manufactured the world’s first miniaturized portable cardiac ultrasound system The Philips Brilliance CT scanner, developed in Israel takes a comprehensive picture of a patient in seconds instead of minutes – a critical difference in the emergency room, where every second counts Medinol pioneered the development of closed cell stent design and many additional innovations to the field of heart catheterization 19
  20. 20. Israeli Medical Devices Breakthroughs 3D Endoscope 3D Dental Mapping Fixed noncooled Magnet Open MRI Simulators for Medical Procedures Revolutionary Rectoscope Intravascular miniaturized MRI imager Spectral Imaging Device Various Stents NiTiNOL Tooling Labor Monitoring 20
  21. 21. Government Support The Law for the Encouragement of Capital Investments Competitive grant program Tax exemption path for manufacturing facilities The Law for the Encouragement of Industrial R&D Increased grants and longer project support for LS Company-Company, Company-Consortia, company- academy support program The Global Enterprise R&D Cooperation Framework The Global Enterprise R&D Project Centers Special tax benefits for R&D centers Tax exemption for venture capital investment Employment grant program Training grant program 21
  22. 22. Summary Israel is a center of innovation and technological excellence Israel is a source for profit driving innovation in the fields of Medtech and Bio-Pharma Foreign companies can cost effectively conduct cutting edge research in Israel Favourable government support programs: Investment grants, tax-exemption and R&D Invest in Israel can support investor by: Technology scouting with our network of partners Helping establishing a presence in Israel 22
  23. 23. State of Israel Ministry of Industry, Trade & Labor Foreign Trade Administration Investment Promotion Center 5 Bank Israel St., Kiryat Ben-Gurion Jerusalem, Israel www.investinisrael.gov.il infoipc@moital.gov.il Tel: +972-2-6662607 Fax:+972-2-6662983

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