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  1. 1. EM
  2. 2. Parietal cell The cell is indicated by the pointer. Note the intracellular canaliculi with microvilli (c) and abundant mitochondria (m) in its cytoplasm. The large number of mitochondria accounts for the acidophilia of parietal cells when seen with light microscopy.
  3. 3. Enterocyte The epithelium is indicated by the pointer. The epithelium is columnar in shape; mitochondria (m) are gathered in both apical aspect and basal aspect of the epithelium. There are microvilli on the apical surface. Note the intercellular cleft (IC) between epithelial cells and a intraepithelial lymphocyte (Ly). A capillary (c) in lamina propria is also shown.
  4. 4. Chief cell Note the nucleus and the extensive Rough ER (rER) in the basal region and membrane bound zymogen granules (ZG) crowed in the apical cytoplasm. Zymogen granules in chief cells are not electron-dense and they are newly packed. The extensive Rough ER accounts for the intense basophilia of chief cells when seen with light microscope.
  5. 5. Exocrine pancreas Pure serous acinus is shown. Note the lumen (L) of the acinus. In each serous-secreting cell surrounding the lumen, there are extensive Rough ER (rER) and a nucleus in the basal aspect and numerous zymogen granules crowded in the apical region of the cell. A large Golgi complex (G) is located above the nucleus. Note that there are two types of zymogen granules in the exocrine pancreas acini: newly packed zymogen granules (Z1) are large and much less electron-dense than the smaller mature granules (Z2). Note a capillary (c), a fibroblast and collagen in the supporting tissue which surrounds the acinus.
  6. 6. Exocrine pancreas Note the RER and nucleus in the basal region and zymogen granules and Golgi complex in the apical region of the acinar cell. Two types of zymogen granules are seen: newly formed condensing granules (c) and mature granules (s).
  7. 7. Paneth cell Note the extensive Rough ER (rER) and nucleus (N) in the basal aspect and zymogen granules in the apical region of the cell. The zymogen granules in Paneth cells are unique for having a dense protein core which is surrounded by a halo of polysaccharide-rich material (the pale region).
  8. 8. Enteroendocrine cell (EEC or APUD cell) The open type EEC, whose apex reaches the lumen of the intestinal gland. Note the basally located secretory granules (S). s
  9. 9. Absorptive cells in large intestine Note the epithelium in columnar shape with microvilli on their luminal surface. Large Golgi complex are seen. Mitochondria (M) are gathered in the apical aspect of the cells. Note the obvious intercellular cleft (IC) with cell membrane leaflets projecting in it, which is characteristic of cells carrying out water absorption function. M IC
  10. 10. Simple columnar cells in gallbladder Similar to the absorptive cells in large intestine, epithelium in gallbladder is columnar in shape with microvilli on their luminal surface. Mitochondria (M) are gathered in both apical and basal aspect of the cell. Note the large intercellular clefts (IC) which are indicative of a water absorption function. M IC
  11. 11. Submandibular gland Note both serous-secreting cells and mucus-secreting cells in the acinus. Serous secreting cells have zymogen granules (Z) in their apical aspect and mucus-secreting cells contain mucinogen-containg vesicles (V) in their cytoplasm. Z V
  12. 12. Liver Hepatocytes (H) line up forming the hepatic cords. Abundant mitochondria (M) and lipid droplets (L) are seen in hepatocytes. Between two hepatocytes, bile canaliculus is delimited (BC). Fenestrated endothelial cells lining the sinusoids have large gaps between them. Erythrocytes (E) are seen in the sinusoids. Between the hepatic cord and endothelial cells, space of Disse is shown (D).
  13. 13. Liver Space of Disse (D) is located between the hepatic cord and endothelial cells (S) of the sinusoid. Mitochondria (M), Rough ER (rER), smooth ER (sER), and lysosomes (Ly) are abundant in the hepatocytes. The side of hepatocytes facing the space of Disse have many microvilli (Mv) projecting into the space of Disse.
  14. 14. Renal medulla The ultrastructural features of collecting tubule (CT), thin limb of loop of Henle (H) and vasa recta (V) are illustrated. All epithelium are supported by thin basement membrane (BM). Between tubules is interstitium (S) which contains a little collagen and scatted fibroblasts (F).
  15. 15. Glomerulus Several capillary loops are illustrated (C). Fenestrated endothelium (E) with open fenestrations (F) are seen. The thick common basement membrane (BM) is obvious. In the Bowman’s space, podocyte (P), primary process (P1) and pedicels (P2) are illustrated. Pedicels are separated by filtration slit (FS).
  16. 16. Glomerulus The fenestrated endothelium (E) with wide fenestrations (F), common basement membrane (BM) and pedicels (P2) of podocyte are illustrated.
  17. 17. A mesangial cell (MC) is illustrated with amorphous mesangial matrix surrounding it. A capillary is seen with a RBC and a leukocyte (L) in its lumen. Common basement membrane (BM) and podocyte (PN) with its processes are also shown. U: Urinary space; Asterisks indicate some of the mesangial cell’s processes (arrow) reaching the capillary lumen, passing between the endothelial cells.
  18. 18. Proximal convoluted tubule Prominent tall microvilli on the apical aspect and the deep infoldings of cell membrane with columns of mitochondria at the basal aspect of the cell are revealed. Immediately beneath the microvilli, pinocytotic vesicles (V) and lysosomes (L) which are involved in resorption and degradation of small proteins are illustrated.
  19. 19. The cell bodies of two podocytes and the alternation of secondary processes from two different cells are shown. The urinary space and the glomerular capillary are indicated.
  20. 20. Filtration barrier in a renal corpuscle. E: fenestrated endothelium; P2: pedicel of the podocyte; FS: filtration slit covered with a thin diaphragm; BM: common basement membrane which consists of a central lamina densa bounded on both sides by a electron-light lamina rara. E P2 FS FS BM
  21. 21. Spermatid In the center is the nucleus, covered by the acrosome. The flagellum can be seen emerging below the nucleus. The manchette, which is a cylindrical bundle of microtubules, can be seen limiting the nucleus laterally.