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MSc student In Isfahan
University Of medical Sciences
Paget’s disease is a chronic condition of bone
characterized by disorder of the normal bone
Characterized by excessive breakdown of bone
tissue followed by abnormal bone formation.
Also known as Osteitis Deformans is a bone
disease unknown cause.
Affecting men twice as freaquently as women.
Named after the England Surgeons Sir James
skeletal disease due to
•As a result, the bone that
is formed is abnormal.
•Certain of genes may
Been associated with
Paget’s disease, including
The Sequestrosome 1
Gene On Chromosome 5.
The cause of Paget’s disease is unknown
Disease may be caused by a virus: Paramyxo virus
Resulting in localized abnormal osteoclastic activity
typical of paget’s disease.
Also, a person’s genes may predispose them to
developing paget’s disease.
Paget’s disease affects skeletal older bone of
There is also an extremely rare form of paget’s
disease in children, referred to as Juvenile Paget’s
In two of every three cases of Paget's disease,
more than one bone is affected
Persists but cellular
Activity is nearly
Initial phase of
Bone resorption by
MANIFESTATIONS - SYMPTOMS
Paget’s disease is more commonly asymptomatic, but
may exhibit a variety of non-specific symptoms due to
increased bone turnover.
The bones that are move commonly affected include the
pelvis, spine, skull, and the long bone.
Individuals may experience any or a combination of the
Difficulty moving your affected joints
Loss of balance
Other symptoms …
SIGNIFICANT LAB TESTS
Blood chemistry (blood patient who have paget’s
disease) results indicate very high alkaline
phosphates levels with normal serum calcium and
There is no known cure for this disease.
Most cases are mild and asymptomatic no
treatment is necessary in symptomatic cases
X-ray of the skull, spine, pelvis and long bone.
MRI (Magnetic Resonance Imaging)
Radionuclide bone scan or RNI (Radionuclide
Radionuclide bone scans readily detect Paget’s
disease even in its very early stage.
Radio graphically of the affected bone typically
demonstrate cortical thickening, with a coarse,
thickened trabecular pattern.
Radiograph of the
fibula and tibia of the
effect of advanced
disease on the fibula
Paget’s disease on pelvis…
involving the left hemi
pelvis and right, there
is severe osteoarthritis
of the left hip but a
relatively normal joint
space in the right hip.