Git Gerd Rcp 2009.

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GIT: GERD from clinical medicine 2009.

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Git Gerd Rcp 2009.

  1. 1. CME Gastroenterology GERD: modern investigation / management Prepared by: Dr. Mohammad Shaikhani, CABM/FRCP.
  2. 3. Introduction: <ul><li>It is a very common under-diagnosed condition resulting in a significant impairment in quality of life. </li></ul><ul><li>24-44% experiencing symptoms for 2 days or more/ week, oesophagiti; 12%, Barrett’s ;1.3%, irrespective of symptoms. </li></ul><ul><li>33% with oesophagitis & 46% with Barrett’s were asymptomatic. </li></ul><ul><li>Severe form can lead to potentially avoidable complications including severe oesophagitis with scarring/stricture formation, Barrett’s& adenoca. </li></ul>
  3. 4. Definitions: <ul><li>The Montreal classification: </li></ul><ul><li>‘ A condition that develops when the reflux of stomach contents causes troublesome symptoms/or complications’. </li></ul><ul><li>The acid component of the gastric refluxate is responsible for most of the symptoms & pathology, but other components, as bile, may also contribute (nonacid reflux). </li></ul><ul><li>Quantification of reflux can be achieved either by measuring acid exposure to the distal oesophagus (pH studies) or movement of liquid in the distal oesophagus (impedance studies). </li></ul><ul><li>Combined impedance&pH measurement characterises all acid & non-acid reflux episodes. </li></ul>
  4. 5. Non-erosive reflux disease : <ul><li>70% of patients with heartburn do not have evidence of erosive changes on endoscopy. </li></ul><ul><li>Of these, a proportion have increased acid reflux on 24-hour pH monitoring, classified as having non-erosive reflux disease (NERD) . </li></ul>
  5. 6. Functional heartburn : <ul><li>A proportion of patients describe typical reflux symptoms without evidence of reflux. </li></ul><ul><li>The Rome II definition ‘an episodic burning in the absence of pathologic GER, motility disorders& any structural explanations’. </li></ul><ul><li>The pathophysiology remains obscure </li></ul>
  6. 7. R eflux oesophagitis <ul><li>Reflux oesophagitis is reflux causing inflammation or ulceration of the oesophagus </li></ul><ul><li>Los Angeles classification is now the most commonly used to quantify GERD damage. </li></ul>
  7. 8. Pathophysiology <ul><li>Results from disruption of the anti-reflux barrier, comprised of: </li></ul><ul><li>The internal (LOS), a 3–4 cm region of circular muscle in the distal oesophagus. </li></ul><ul><li>External, the crural diaphragm. </li></ul><ul><li>Oesophageal clearance by eso peristalsis. </li></ul><ul><li>Neutralisation mechanisms by saliva. </li></ul><ul><li>Abnormal TLOSRs not initiated by a swallow, result in the reflux of gastric fluid & gas, account for 90% of reflux episodes, usually mild-moderate GERD. </li></ul><ul><li>The TLOSR reflex is initiated by tension receptors in the stomach mediated by a vagovagal pathway via the brainstem leading to simultaneous relaxation of crura, LOS & inhibition of peristalsis, inhibited by (GABA-B) receptor . </li></ul><ul><li>Hiatus hernias increase the magnitude of reflux during TLOSRs. </li></ul>
  8. 9. Pathophysiology <ul><li>Hypotensive LOS, is responsible for more severe oesophagitis. </li></ul><ul><li>Reflux occurs more frequently when the pressure in the LOS is  from 4-10 mm Hg. </li></ul><ul><li>Factors which relax the LOS, as caffeine, fat, smoking, drugs (CCB &nitrates)& gastric distention, will increase reflux. </li></ul><ul><li>The association of increased BMI& GORD remains unclear. </li></ul><ul><li>Acid in the distal oesophagus is neutralised by saliva& any processes reducing saliva production results in a delay in acid neutralisation& nocturnal reflux episodes are prolonged due to depressed salivation. </li></ul><ul><li>Impaired distal oesophageal peristalsis results in prolonged acid exposure to acid reflux episodes,apparent in hiatus hernias &ulcerative oesophagitis due to severe GERD, systemic sclerosis& achalasia, where there is peristaltic dysfunction. </li></ul>
  9. 10. Pathogenic factors in GERD: <ul><li>LES& crural function (hiatus hernia) </li></ul><ul><li>TLESR. </li></ul><ul><li>Oesophageal clearance mechanisms (oesophageal motility, saliva) </li></ul><ul><li>Refluxate (gastric acid, bile, enzymes) </li></ul><ul><li>Mucosal response to refluxate </li></ul><ul><li>Drugs affecting anti-reflux barrier (nitrates, calcium antagonists) </li></ul><ul><li>Diet (fat, caffeine). </li></ul>
  10. 11. Clinical features of GERD: <ul><li>The most common symptom;s heartburn, regurgitation, belching, epigastric pain, chest pain, dysphagia& acid brash. </li></ul><ul><li>Less frequent symptoms include odynophagia, globus, nausea & pharyngeal symptoms. </li></ul><ul><li>Symptoms of GORD, can be highly variable. </li></ul><ul><li>Diagnosis of GORD can be difficult. </li></ul><ul><li>For example the presence of heartburn is not entirely predictive of acid reflux. </li></ul><ul><li>Only 5–10% of episodes of acid reflux produce heartburn. </li></ul><ul><li>The positive predictive value of heartburn for endoscopic oesophagitis is poor, although the negative predictive value is slightly better. </li></ul>
  11. 12. Diagnosis of GERD:emprical <ul><li>Most patients with typical symptoms of GORD do not require investigation and will respond to a trial of (PPI). </li></ul><ul><li>High dose PPI 40 mgm Omeprazole twice daily for 1 week) has a sensitivity of 80% as a diagnostic test for GORD. </li></ul>
  12. 13. Diagnosis of GERD:OGD <ul><li>Patients of any age presenting with typical reflux symptoms with the following alarm symptoms should have an urgent endoscopy: </li></ul><ul><li>Dysphagia </li></ul><ul><li>Unintentional weight loss </li></ul><ul><li>GIB </li></ul><ul><li>Anaemia </li></ul><ul><li>Persistent vomiting. </li></ul><ul><li>Endoscopy should also be performed before oesol pH studies. </li></ul><ul><li>A negative endoscopy does not exclude NERD. </li></ul><ul><li>Screening endoscopy for the diagnosis of Barrett’s in patients of any age with a history of chronic heartburn cannot be recommended, as the absolute risk of adenocarcinoma is < 1:1,000&40% of who develop adenocarcinoma in association with Barrett’s oesophagus do not have a history of heartburn. </li></ul>
  13. 14. Diagnosis of GERD:Ph studies <ul><li>Acid exposure of the distal oesophagus can be measured either by placing a nasooesophageal probe 5 cm above the physiological LOS or by placing a wireless capsule probe endoscopically. Measurements of pH can be taken for either 24 or 48 hours. </li></ul><ul><li>PPI or (H2A) should bes topped one week before the procedure. </li></ul><ul><li>Patients who have oesophagitis demonstrated on endoscopy do not need pH studies for diagnostic purposes. </li></ul><ul><li>Patients who have refractory symptoms to a trial of PPI may have inadequate acid suppression. </li></ul><ul><li>This can be demonstrated by pH studies obtained while the patient is taking PPIs. It is reasonable as an alternative, however, to escalate PPI dose in these patients. </li></ul>
  14. 17. Diagnosis of GERD: Eso manometry <ul><li>Does not influence the management except in a few circumstances: </li></ul><ul><li>Where oes motility abnormalities are suspected as achalasia. </li></ul><ul><li>To correctly place the pH probe 5 cm above the LOS. </li></ul><ul><li>Prior to anti-reflux surgery, although studies suggest this very rarely changes outcome or helps tailor surgery. </li></ul>
  15. 18. Diagnosis of GERD: MC Intraluminal impedance. <ul><li>Useful for the investigation of PPI-resistant reflux symptoms although its role has not yet been completely defined. </li></ul>
  16. 19. Treatment: <ul><li>The is to effectively control symptoms&prevent associated complications by adopting a stepped approach. </li></ul><ul><li>The effects of drugs on either the healing and/or symptom relief of oesophagitis or NERD is generally greater in patients with endoscopy proven oesophagitis . </li></ul>
  17. 20. Treatment: Life style <ul><li>Simple manoeuvres outlined below may have a marked effect on symptoms: </li></ul><ul><li>Dietary changes: avoiding fat, caffeine& alcohol </li></ul><ul><li>Avoiding late meals: Nocturnal reflux can be minimised by consuming small meals long before slee.p </li></ul><ul><li>Although the association of obesity is unclea,rbut there is association with oesophageal adenocarcinoma& many other well-known diseases, so weight loss is suggested as part of management. </li></ul>
  18. 21. Treatment: antacids/alginates <ul><li>Antacids consist of calcium carbonate, magnesium& aluminum salts in various compounds or combinations. </li></ul><ul><li>The effect of antacids is due to partial neutralisation of gastric HCL & inhibition of the proteolytic enzyme, pepsin. </li></ul><ul><li>Alginate mechanism of action is due to the formation of a gel in the presence of gastric acid. </li></ul><ul><li>Alginate-based raftforming usually contain sodium or potassium bicarbonate; in the presence of gastric acid,converted to carbon dioxide, which becomes entrapped within the gel precipitate, converting it into a foam which floats on the surface of the gastric contents, much like a raft on water& providing a relatively pH-neutral barrier. </li></ul><ul><li>They improve reflux symptoms, but do not heal oesophagitis. </li></ul><ul><li>They are indicated for very mild symptoms. </li></ul><ul><li>No role for antacids/ alginates in the maintenance of GORD . </li></ul>
  19. 22. Treatment: Acid inhibition <ul><li>H2As / PPIs should be prescribed for patients with symptoms not well controlled on lifestyle changes or antacids/alginates. </li></ul><ul><li>PPI are prodrugs, which are activated in the acidic canalicular space of the parietal cell, inhibiting the final pathway of acid secretion and suppress acid production for several days. </li></ul><ul><li>(H2A) reversibly bind H2 gastric parietal cell receptors. </li></ul><ul><li>Both H2As&PPIs effectively heal and prevent relapse of oesophagitis, but PPIs are superior to both H2As/ prokinetics. </li></ul><ul><li>The efficacy of PPIs is dose dependant& mucosal healing is dependent upon the proportion of time the intra-gastric pH is  4 </li></ul><ul><li>. The dose effect of H2As , is constant. </li></ul><ul><li>At equivalent doses, all the PPIs appear to be equally efficacious. </li></ul><ul><li>PPI should be taken 30 minutes before meals. </li></ul>
  20. 23. Treatment: Non-repons to PPI <ul><li>Patients with typical reflux symptoms, who do not respond to initial courses of PPIs fall into one of the following groups: </li></ul><ul><li>Patients with an alternative diagnosis. </li></ul><ul><li>Patients with inadequate acid suppression </li></ul><ul><li>Patients with functional heartburn . </li></ul>
  21. 24. Treatment: Non-repons to PPI <ul><li>If symptom control is not achieved after four weeks, we suggest extending PPI therapy to two months as healing improve from 68- 84% </li></ul><ul><li>A proportion of patients fail to adequately increase the gastric pH  4 with standard-dose PPIs. Doubling the PPI dose does appear to have an additional effect specially in patients with more severe oesophagitis (LA grade C and D. </li></ul><ul><li>A proportion of patients experience nocturnal acid breakthrough, even with twice daily PPI,so addition of an H2A before sleep may reduce nocturnal symptoms, however, the benefit may be limited by tachyphylaxis. </li></ul>
  22. 26. Treatment: Prokinetic agents <ul><li>Existing drugs have not shown promise </li></ul><ul><li>Little data exist for domperidone. </li></ul><ul><li>GABA-B agonists may be potential targets for future developments. </li></ul>
  23. 27. Treatment: Surgery <ul><li>There is no statistical difference between outcomes of medical therapy (PPI or H2A)&surgery. </li></ul><ul><li>Given the recognised postoperative mortality associated with surgery of up to 0.4%, this is only recommended if patients with provenwho do not respond to medical therapy, do not wish to take medication or have associated respiratory symptoms not responding to PPI. </li></ul><ul><li>The most common complications of Nissen fundoplication include dysphagia & gas-bloat syndrome in up to 50% of patients. Furthermore, after a median of five years, up to 50% of patients after surgery require medication to control symptoms. </li></ul>

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