Calcitriol<br />Muhammad Shahzeb<br />Roll # 177<br />
Layout:<br />Introduction<br />Biosynthesis and regulation<br />Transport<br />Mechanism of action<br />Metabolism<br />Me...
Introduction:<br />Calcitriol also called 1,25-dihydroxycholecalciferol, <br />active form of vitamin D with three alcohol...
Biosynthesis and its regulation:<br />Produced in the cells of the proximal tubule of the nephron <br />By the action of 2...
                                                                             skin<br />7-dehydro cholesterol<br />Previtam...
Transport:<br />Vitamin D-binding protein belongs to the albumin  family<br />458 amino acids <br />Coded  by 1690 nucleot...
Mechanism of action:<br />
Metabolism:<br />Half life - approx. 5-8 hours.<br />This enzyme plays a role in calcium homeostasis and of calcitriol<br ...
            Metabolic Actions <br />
Intestinal Ca+2 absorption:<br />Increases the absorption of Ca<br />Increases the production of Calmodulin (CaBP).<br />
On bones:<br />    Type 1 Collagen <br />osteoclastin<br />Osteoblasts                 Osteoclast<br />    absorption of C...
Action on kidneys<br />A major action of calcitriol is to regulate renal 25-hydroxyvitamin D,-1-hydroxylase<br />It has be...
On skeletal and cardiac muscles<br />   the rate of Ca uptake by sarcoplasmic reticulum of skeletal muscles<br />  skeleta...
On cancer cells:<br />Cancerous cells have receptors for calcitriol<br />Calcitriol represses the cell proliferation<br />...
On skin:<br />  melanin synthesis.<br />preventing the skin penetration of sunlight.<br />7-dehydrocholesterol is not conv...
Endocrine functions:<br />Parathyroid Gland:<br />Inhibits the proliferation of parathyroid cells<br />Inhibits the parath...
Pancreas:<br />vitamin D deficiency inhibited insulin secretion from the  pancreas, whereas vitamin D repletion improved i...
Disorders related to calcitriol:<br />Vitamin D deficiency:<br />Type I:<br />Type II:<br />Body is unable to utilize vita...
Diseases related to vitamin D deficiency<br />Rickets<br />- Softening of bones in children potentially leading to fractur...
Treatment and prevention:<br />Increase dietary intake of calcium, phosphates and vitamin D.<br />Exposure to sunlight<br ...
Osteomalacia<br />Osteomalacia is the softening of the bones due to defective bone mineralization<br />Signs and Symptoms<...
Treatment <br />Oral administration of vitamin D. <br />Osteomalaciadue to malabsorption may require treatment by injectio...
Hypervitaminosis D<br />Is tolerable <br />But deleterious in extreme large dosage 500-1000 times than normal<br />Effects...
Delayed effects: persistent hypercalcemia and hyperphospatemia may result<br />Urinary lithasis<br />Metastatic calcificat...
Bronchi
Arteries
Muscles</li></li></ul><li>review<br />
References<br />Research paper by U Sipmson & Ronald <br />www.wikipedia.com<br />
Acknowlegdements<br />Allah Almighty<br />Parents<br />Prof. Dr. Khawaja Muhammad Fayyaz<br />Dr. ShafqatNazir<br />Dr. Ja...
Friends<br />HaroonGull<br />UsmanBaig.<br />Musa Khan<br />Ali Aasil<br />Talha Tariq<br />Mudassir Butt<br />MaazBarlas<...
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Calcirtriole

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Calcirtriole

  1. 1.
  2. 2. Calcitriol<br />Muhammad Shahzeb<br />Roll # 177<br />
  3. 3. Layout:<br />Introduction<br />Biosynthesis and regulation<br />Transport<br />Mechanism of action<br />Metabolism<br />Metabolic Actions<br />Abnormalities associated with calcitriol<br />- Hypovitamenosis D <br />- Hypervitamenosis D<br />
  4. 4. Introduction:<br />Calcitriol also called 1,25-dihydroxycholecalciferol, <br />active form of vitamin D with three alcohol groups<br />It increases the level of calcium (Ca2+) in the blood<br />
  5. 5. Biosynthesis and its regulation:<br />Produced in the cells of the proximal tubule of the nephron <br />By the action of 25-hydroxyvitamin D3 1-alpha-hydroxylase<br />The activity of the enzyme is stimulated by <br />- PTH.<br />- Prolactin <br />- Decreased levels of serum phosphate <br />
  6. 6. skin<br />7-dehydro cholesterol<br />Previtamin D3<br />Vitamin D3<br />25-hydroxylase<br /> liver<br />25-hydroxycholcalciferol<br />25 hydroxycolcalciferol 1-hydroxylase<br /> kidney<br />1,25-dihydroxycol calciferol<br />
  7. 7.
  8. 8. Transport:<br />Vitamin D-binding protein belongs to the albumin family<br />458 amino acids <br />Coded by 1690 nucleotides on chromosome 4<br />Found in <br />-plasma, <br />-cerebrospinal fluid <br />-on the surface of many cell types<br />It binds to vitamin D and its plasma metabolites and transports them to target tissues<br />
  9. 9. Mechanism of action:<br />
  10. 10. Metabolism:<br />Half life - approx. 5-8 hours.<br />This enzyme plays a role in calcium homeostasis and of calcitriol<br />24-hydroxylase<br />calcitriol<br />Calcitric<br />acid<br />
  11. 11. Metabolic Actions <br />
  12. 12.
  13. 13. Intestinal Ca+2 absorption:<br />Increases the absorption of Ca<br />Increases the production of Calmodulin (CaBP).<br />
  14. 14. On bones:<br /> Type 1 Collagen <br />osteoclastin<br />Osteoblasts Osteoclast<br /> absorption of Cain bones<br />
  15. 15.
  16. 16. Action on kidneys<br />A major action of calcitriol is to regulate renal 25-hydroxyvitamin D,-1-hydroxylase<br />It has been shown that calcitriol brings about a suppression of this enzyme<br />Thus it helps to regulate the formation of calcitriol by negative feedback inhibition.<br />
  17. 17. On skeletal and cardiac muscles<br /> the rate of Ca uptake by sarcoplasmic reticulum of skeletal muscles<br /> skeletal muscle mass<br />Can cause the calcification of cardiac muscle <br />Lead to myocardial failure<br />
  18. 18. On cancer cells:<br />Cancerous cells have receptors for calcitriol<br />Calcitriol represses the cell proliferation<br />So it along with its analogs can be use for treating the cancer<br />
  19. 19. On skin:<br /> melanin synthesis.<br />preventing the skin penetration of sunlight.<br />7-dehydrocholesterol is not converted to pre-vitamin D<br />Feedback regulation.<br />
  20. 20. Endocrine functions:<br />Parathyroid Gland:<br />Inhibits the proliferation of parathyroid cells<br />Inhibits the parathyroid genes form transcription<br />Thus can be used to treat hyper-parathyroidism.<br />Pituitary gland<br />Increases prolactin synthesis and secretion from pituitary cells.<br />
  21. 21. Pancreas:<br />vitamin D deficiency inhibited insulin secretion from the pancreas, whereas vitamin D repletion improved insulin secretion<br />
  22. 22. Disorders related to calcitriol:<br />Vitamin D deficiency:<br />Type I:<br />Type II:<br />Body is unable to utilize vitamin D due to defect in the receptor of calcitriol.<br />hydroxylase<br />25,OH –D3<br />calcitriol<br />
  23. 23. Diseases related to vitamin D deficiency<br />Rickets<br />- Softening of bones in children potentially leading to fractures and deformity in bones<br /><ul><li>The predominant cause is a vitamin Ddeficiency</li></ul>Sign & symptoms:<br />Bone pain or tenderness<br />dental problems<br />muscle weakness<br />Growth disturbance<br />Hypocalcemia<br />Tetany<br />
  24. 24. Treatment and prevention:<br />Increase dietary intake of calcium, phosphates and vitamin D.<br />Exposure to sunlight<br />cod liver oil<br />
  25. 25. Osteomalacia<br />Osteomalacia is the softening of the bones due to defective bone mineralization<br />Signs and Symptoms<br />Weak bones<br />Bone pain<br />Muscle weakness<br />Hypocalcemia<br />Compressed vertebrae<br />Fractures<br />Bone softening<br />Bending of bones<br />Pain<br />
  26. 26. Treatment <br />Oral administration of vitamin D. <br />Osteomalaciadue to malabsorption may require treatment by injection of significant amounts of vitamin D.<br />
  27. 27. Hypervitaminosis D<br />Is tolerable <br />But deleterious in extreme large dosage 500-1000 times than normal<br />Effects:<br />Immediate effects:<br />Anorexia<br />Thirst<br />Lassitude(fatigue) <br />Constipation <br />Polyuria<br />Nausea <br />Vomiting <br />Diarrhoea<br />
  28. 28. Delayed effects: persistent hypercalcemia and hyperphospatemia may result<br />Urinary lithasis<br />Metastatic calcification<br />Effecting <br /><ul><li>Kidneys
  29. 29. Bronchi
  30. 30. Arteries
  31. 31. Muscles</li></li></ul><li>review<br />
  32. 32.
  33. 33. References<br />Research paper by U Sipmson & Ronald <br />www.wikipedia.com<br />
  34. 34. Acknowlegdements<br />Allah Almighty<br />Parents<br />Prof. Dr. Khawaja Muhammad Fayyaz<br />Dr. ShafqatNazir<br />Dr. JamshedIqbal.<br />Mam Jawaria<br />Mam Uummaya<br />
  35. 35. Friends<br />HaroonGull<br />UsmanBaig.<br />Musa Khan<br />Ali Aasil<br />Talha Tariq<br />Mudassir Butt<br />MaazBarlas<br />AtifRana<br />AbubakrDastgir<br />AtharSaleem<br />GulamMurtaza Sahib<br />
  36. 36. Thanks to all of <br />U!<br />

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