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Actin and myosin

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Actin and myosin

  1. 1. 100’s of free ppt’s from www.pptpoint.com library
  2. 2. actin and myosin dr shabeel pn www.hi-dentfinishingschool.blogspot.com
  3. 3. actin
  4. 4. actin troponin
  5. 5. actin troponin tropomyosin
  6. 6. actin troponin tropomyosin
  7. 7. actin troponin tropomyosin myosin binding site
  8. 9. Ca 2+ Ca 2+ Ca 2+ Ca 2+
  9. 10. Ca 2+ Ca 2+ Ca 2+ Ca 2+ Calcium ions are released from the sarcolemma after stimulation from the T system
  10. 11. Ca 2+ Ca 2+ Ca 2+ Ca 2+
  11. 12. Ca 2+ Ca 2+ Ca 2+ Ca 2+ the calcium ions bind to the troponin and changes its shape
  12. 13. Ca 2+ Ca 2+ Ca 2+ Ca 2+ the calcium ions bind to the troponin and changes its shape
  13. 14. Ca 2+ Ca 2+ Ca 2+ Ca 2+
  14. 15. Ca 2+ Ca 2+ Ca 2+ Ca 2+
  15. 16. Ca 2+ Ca 2+ Ca 2+ Ca 2+ the troponin displaces the tropomyosin and exposes the myosin binding sites
  16. 17. Ca 2+ Ca 2+ Ca 2+ Ca 2+
  17. 18. Ca 2+ Ca 2+ Ca 2+ Ca 2+
  18. 19. Ca 2+ Ca 2+ Ca 2+ Ca 2+ the bulbous heads of the myosin attach to the binding sites on the actin filaments
  19. 20. Ca 2+ Ca 2+ Ca 2+ Ca 2+
  20. 21. Ca 2+ Ca 2+ Ca 2+ Ca 2+
  21. 22. Ca 2+ Ca 2+ Ca 2+ Ca 2+ the myosin heads change position to achieve a lower energy state and slide the actin filaments past the stationary myosin
  22. 23. Ca 2+ Ca 2+ Ca 2+ Ca 2+ A P i P i P i A P i P i P i A P i P i P i
  23. 24. Ca 2+ Ca 2+ Ca 2+ Ca 2+ A P i P i P i A P i P i P i A P i P i P i
  24. 25. Ca 2+ Ca 2+ Ca 2+ Ca 2+ ATP binds to the bulbous heads and causes it to become detached A P i P i P i A P i P i P i A P i P i P i
  25. 26. Ca 2+ Ca 2+ Ca 2+ Ca 2+ ATP binds to the bulbous heads and causes it to become detached A P i P i P i A P i P i P i A P i P i P i
  26. 27. Ca 2+ Ca 2+ Ca 2+ Ca 2+ A P i P i P i A P i P i P i A P i P i P i hydrolysis of ATP provides the energy to “re-cock” the heads
  27. 28. Ca 2+ Ca 2+ Ca 2+ Ca 2+ A P i P i P i A P i P i P i A P i P i P i hydrolysis of ATP provides the energy to “re-cock” the heads
  28. 29. Ca 2+ Ca 2+ Ca 2+ Ca 2+ A P i P i P i A P i P i P i A P i P i P i
  29. 30. Ca 2+ Ca 2+ Ca 2+ Ca 2+ A P i P i P i A P i P i P i A P i P i P i calcium ions are re-absorbed back into the T system
  30. 31. Ca 2+ A P i P i P i A P i P i P i A P i P i P i calcium ions are re-absorbed back into the T system
  31. 32. Ca 2+ A P i P i P i A P i P i P i A P i P i P i the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
  32. 33. Ca 2+ A P i P i P i A P i P i P i A P i P i P i the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
  33. 34. Ca 2+ A P i P i P i A P i P i P i A P i P i P i the troponin reverts to its normal shape and the tropomyosin move back to block the myosin binding sites
  34. 35. Ca 2+ A P i P i P i A P i P i P i A P i P i P i phosphocreatine regenerates ATP
  35. 36. Ca 2+ A P i P i P i A P i P i P i A P i P i P i phosphocreatine regenerates ATP
  36. 37. Ca 2+ A P i P i P i A P i P i P i A P i P i P i phosphocreatine regenerates ATP

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