Acromegaly 19.07.08

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Acromegaly 19.07.08

  1. 1. Acromegaly dr shabeel’s presentations
  2. 2. Acromegaly <ul><li>Due to increase in growth hormone </li></ul><ul><li>Pituitary tumour – macro-adenoma </li></ul><ul><li>GH hyper secretion before epiphyseal fusion – Gigantism </li></ul><ul><li>After epiphyseal fusion - Acromegaly </li></ul>
  3. 3. Clinical features <ul><li>Skin thickening </li></ul><ul><li>Increased sweating </li></ul><ul><li>Headache </li></ul><ul><li>Enlargement of lips / nose / tongue </li></ul><ul><li>Increased heel pad thickness </li></ul><ul><li>Myopathy / arthropathy </li></ul><ul><li>Carpal tunnel syndrome </li></ul><ul><li>Visceromegaly </li></ul>
  4. 6. Contd…….. <ul><li>Large hands & feet </li></ul><ul><li>Prognathism </li></ul><ul><li>Skull enlargement </li></ul><ul><li>Kyphosis </li></ul><ul><li>Glucose intolerance / DM </li></ul><ul><li>HT </li></ul>
  5. 8. Investigations <ul><li>GH estimation during OGTT </li></ul><ul><li>Normally plasma GH falls < 2 mU /L during glucose load </li></ul><ul><li>Assessment of each hormones </li></ul><ul><li>MRI </li></ul>
  6. 9. Management <ul><li>Surgery </li></ul><ul><li>Radiotherapy </li></ul>

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