Apaza poster 2 28-05 b

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Poster of past drug in development for Inflammatory Bowel Disease (including Ulcerative Colitis and Crohn's Diseases).

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Apaza poster 2 28-05 b

  1. 1. Structure Determination of APAZA TM M. Ferro , S. Donaldson and B. Radha Krishnan Nobex Corporation, P.O. Box 13940, Research Triangle Park, NC 27709 ABSTRACT INTRODUCTION AND METHODS RESULTS CONCLUSIONS DISCUSSIONS C 14 CH 2 45.86 C 6 CH 117.34 C 2 C 119.54 C 9 , C 13 CH 121.32 C 3 CH 125.49 C 5 CH 126.32 C 10 , C 12 CH 129.96 C 8 C 142.26 C 4 C 142.56 C 11 C 150.14 C 7 C 167.98 C 1 C 170.98 C 15 C 174.51 Assignment Saturation (DEPT and 13 C) Chemical Shift (ppm) C 14 - H 2 -- s 2H 3.35 OH -- s 1H 3.43 C 6 - H 8.5 d 1H 6.77 C 10 - H , C 12 - H 8.5 d 2H 7.40 C 9 - H , C 13 - H 8.5 d 2H 7.69 C 5 - H 8.5, 2.5 dd 1H 7.78 C 3 - H 2.5 d 1H 8.27 Free acid or N- H -- s 1H 17.63 Assignment J coupling (Hz) Multiplicity Relative Intergration Chemical Shift (ppm)

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