EMD-000271-01
Improved asthma diagnosis

Case 1:

Peter is a 5 year old boy who has had
a chronic cough for the last 8 weeks.
 • History...
Case 1:

Peter is a 5 year old boy who has had
a chronic cough for the last 8 weeks.


 Questions:
 • Does Peter have an a...
Case 1:

Peter is a 5 year old boy who has had
a chronic cough for the last 8 weeks.

 Diagnosis:
 • Persistent atopic ast...
Improved asthma diagnosis

Case 2:

Sebastian is a 10 year old boy
who has had asthma since the age of 5.
• Is using ICS
•...
Case 2:

Sebastian is a 10 year old boy
who has had asthma since the age of 5.


• The FENO value shows that he has no ong...
Case 2:

Sebastian is a 10 year old boy
who has had asthma since the age of 5.




 • Further investigations showed that h...
Prediction of steroid response / dose titration

Case 3:

Eric is 31 and suffers from chronic rhinitis and seasonal
allerg...
Case 3:

Eric is 31 and suffers from chronic rhinitis and seasonal
allergies during spring and midsummer.
In addition he h...
Case 3:

Eric is 31 and suffers from chronic rhinitis and seasonal
allergies during spring and midsummer.
In addition he h...
Rapid identification of non-compliance

Case 4:

Eva is 21 years old and has suffered from allergies for
many years. She w...
Case 4:
Eva is 21 years old and has suffered from allergies for
many years. She was diagnosed with asthma 5 years ago.



...
Case 4:

Eva is 21 years old and has suffered from allergies for
many years. She was diagnosed with asthma 5 years ago.

 ...
Notification of loss of control

Case 5:

Sara is a 7 year old girl with atopic asthma.
She is sensitive to pollen and mit...
Case 5:

Sara is a 7 year old girl with atopic asthma.
She is sensitive to pollen and mites.


 Further questions:
 • Does...
Case 5:

Sara is a 7 year old girl with atopic asthma.
She is sensitive to pollen and mites.


 Actions:
 • Inhalation tec...
Notification of loss of control

Case 6:

Francesca is a 14 year old girl with atopic asthma.
She has been treated with IC...
Case 6:

Francesca is a 14 year old girl with atopic asthma.
She has been treated with ICS since she was diagnosed
at the ...
Prediction of asthma relapse

Case 7:
Simon is a 15 year old boy who has had mild asthma and
has been on a low dose of ICS...
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Asthmatic Cases

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Asthmatic Cases

  1. 1. EMD-000271-01
  2. 2. Improved asthma diagnosis Case 1: Peter is a 5 year old boy who has had a chronic cough for the last 8 weeks. • History of bronchitis • No food allergy • No atopic dermatitis Differential diagnosis • Post-viral cough • Habit cough • Allergíc rhinitis • Sinusitis • Asthma • Pnemonia • Foreign body 2 EMD-000271-01
  3. 3. Case 1: Peter is a 5 year old boy who has had a chronic cough for the last 8 weeks. Questions: • Does Peter have an allergy? • Is there an inflammation in the airways? • Does Peter have normal lung function? Results of lab tests: • FENO: 22 ppb • Peak flow: 100% predicted • Spirometry: - • Specific-IgE (skin test/RAST test): Positive to house dust mite 3 EMD-000271-01
  4. 4. Case 1: Peter is a 5 year old boy who has had a chronic cough for the last 8 weeks. Diagnosis: • Persistent atopic asthma Actions: • ICS or LTRA Results: • Cough remitted by the end of the second week and he became asymptomatic • FENO: 7 ppb after 4 weeks 4 EMD-000271-01
  5. 5. Improved asthma diagnosis Case 2: Sebastian is a 10 year old boy who has had asthma since the age of 5. • Is using ICS • Nocturnal coughing • Fatigued during physical exercise • Compliant and correct inhalation technique • FENO is 8 ppb Questions: • Does Sebastian have (allergic) asthma or should another diagnosis be considered? • In what way is the FENO value informative? 5 EMD-000271-01
  6. 6. Case 2: Sebastian is a 10 year old boy who has had asthma since the age of 5. • The FENO value shows that he has no ongoing eosinophilic inflammation, i.e. no allergic asthma • IgE tests were negative and indicated that he was non-atopic Actions: • Discontinue Sebastian’s ICS • Find an explanation for the symptoms -Non-allergic asthma (no eosinophils) -Gastrointestinal reflux -Port-nasal drip -Nervous hyperventilation -Rhinitis -Sinusitis 6 EMD-000271-01
  7. 7. Case 2: Sebastian is a 10 year old boy who has had asthma since the age of 5. • Further investigations showed that he had sinusitis, which was treated • FENO remained stable after ICS was discontinued 7 EMD-000271-01
  8. 8. Prediction of steroid response / dose titration Case 3: Eric is 31 and suffers from chronic rhinitis and seasonal allergies during spring and midsummer. In addition he has recently developed breathing problems. He is using antihistamines Results of examination: • Physical examination is normal • FENO is 75 ppb • Spirometry is normal Question: • What does the examination and especially the FENO value tell you? 8 EMD-000271-01
  9. 9. Case 3: Eric is 31 and suffers from chronic rhinitis and seasonal allergies during spring and midsummer. In addition he has recently developed breathing problems. • Eric is in addition to his rhinitis and allergy having an ongoing eosinophilic inflammation • He is prescribed ICS as he will most probably respond to steroids as he is having a high FENO value 9 EMD-000271-01
  10. 10. Case 3: Eric is 31 and suffers from chronic rhinitis and seasonal allergies during spring and midsummer. In addition he has recently developed breathing problems. Figure showing ICS dose adjustment with maintained control 10 EMD-000271-01
  11. 11. Rapid identification of non-compliance Case 4: Eva is 21 years old and has suffered from allergies for many years. She was diagnosed with asthma 5 years ago. • Eva has been prescribed ICS / LABA and SABA when needed • She is experiencing breathing problems Results of examination: • RAST shows that she is sensitized towards cat (25.1 kU/l), dog (9.2 kU/l), horse (8.1 kU/l), birch (22.3 kU/l), timothy (21.6 kU/l) and cladosporium (1.5 kU/l) • FENO is 55 ppb Questions: • Why does Eva have symptoms despite the fact she is prescribed medication? • What does the FENO value reveal about the inflammation? 11 EMD-000271-01
  12. 12. Case 4: Eva is 21 years old and has suffered from allergies for many years. She was diagnosed with asthma 5 years ago. Further questions: • Does she take the medication? • Does she have the correct inhalation technique? • Has anything been changed in the allergen exposure? • Has she the optimal steroid dose? • Has her asthma deteriorated? • Is she steroid resistant? 12 EMD-000271-01
  13. 13. Case 4: Eva is 21 years old and has suffered from allergies for many years. She was diagnosed with asthma 5 years ago. Actions: • Eva gets detailed instructions for how to use the inhaler • The dose of ICS/LABA is gradually increased Figure showing decreased inflammation following 13 improved compliance and increased dose of ICS/LABA EMD-000271-01
  14. 14. Notification of loss of control Case 5: Sara is a 7 year old girl with atopic asthma. She is sensitive to pollen and mites. • Sara is on ICS • She is having no symptoms (according to her father) • She is tired and spends a lot of time reading Questions: • Is Sara really asymptomatic? • Does her father fully understand how she feels? • Is her asthma under control? Results of examination: • Physical examination does not show any abnormalities • FENO is 58 ppb • Lung function is normal 14 EMD-000271-01
  15. 15. Case 5: Sara is a 7 year old girl with atopic asthma. She is sensitive to pollen and mites. Further questions: • Does she take the medication? • Does she have the correct inhalation technique? • Has anything been changed in the allergen exposure? • Does she have the optimal steroid dose? • Has her asthma deteriorated? • Is she steroid resistant? 15 EMD-000271-01
  16. 16. Case 5: Sara is a 7 year old girl with atopic asthma. She is sensitive to pollen and mites. Actions: • Inhalation technique was reviewed and optimized • ICS dose was increased • Bed covers Result: • FENO dropped to 24 ppb after 4 weeks Sarah’s asthma is under control but has to be monitored on a regular basis. 16 EMD-000271-01
  17. 17. Notification of loss of control Case 6: Francesca is a 14 year old girl with atopic asthma. She has been treated with ICS since she was diagnosed at the age of 7. • On a fixed dose of ICS • Compliant • FENO normally 7-13 ppb Stable, symptomless and with low FENO values for > 6 months The steroid dose is reduced 17 EMD-000271-01
  18. 18. Case 6: Francesca is a 14 year old girl with atopic asthma. She has been treated with ICS since she was diagnosed at the age of 7. Francesca returns after two months Results of examination: • No symptoms • Physical examination is normal • FENO shows a slight increase to 18 ppb • Spirometry is normal Francesca is later on experiencing breathing problems while training during the pollen season Results new of examination: • Physical examination is normal • FENO is now 30 ppb • Spirometry is normal Actions: Francesca is advised to use the original dose of ICS during the pollen season as she was symptom free on that dose 18 EMD-000271-01
  19. 19. Prediction of asthma relapse Case 7: Simon is a 15 year old boy who has had mild asthma and has been on a low dose of ICS for the past several years. Results of examination: • No symptoms. • Physical examination is normal. • FENO is 15 ppb. • Spirometry is normal. Stable, symptomless and with normal FENO values for > 6 months The steroid dose is reduced Simon returns after two months Results of examination: • No symptoms. • Physical examination is normal. • FENO is now 17 ppb. The steroids are discontinued 19 EMD-000271-01

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