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Consensus Definition of Osteoarthritis

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Epidemiology of OA

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Consensus Definition of Osteoarthritis

  1. 1. Consensus Definition of OsteoarthritisConsensus Definition of Osteoarthritis “OA diseases are a result of both mechanical and biologic events that destabilize the normal coupling of degradation and synthesis of articular cartilage chondrocytes and extracellular matrix, and subchondral bone. Although they may be initiated by multiple factors, OA diseases involve all of the tissues of diarthrodial joint. Ultimately, OA diseases are manifested by morphologic, biochemical, molecular, and biomechanical changes of both cells and matrix which lead to a softening, fibrillation, ulceration, loss of articular cartilage, sclerosis and eburnation of subchondral bone, osteophytes, and subchondral cysts. When clinically evident, OA diseases are characterized by joint pain, tenderness, limitation of movement, crepitus, occasional effusion, and variable degrees of inflammation without systemic effects” From: Kuettner & Goldberg. Introduction. In: Kuettner, Goldberg, editors. Osteoarthritis disorders. 1995 Provided by S Chubinskaya
  2. 2. Risk Factors for Incident OsteoarthritisRisk Factors for Incident Osteoarthritis Body Weight Gender Bone Mineral Density Postmenopausal Hormone Replacement Therapy Congenital Abnormalities Meniscectomy Other Factors Age Injury Infection Occupational triggers Nonoccupational Physical Activity Osteoarthritis Genetics Metabolic Disorders Biomechanics Adapted from: Sharma & Kapoor “Epidemiology of Osteoarthritis” In: Osteoarthritis, 4th Ed. 2007 Provided by S Chubinskaya
  3. 3. Risk Factors for IncidentRisk Factors for Incident OsteoarthritisOsteoarthritis • Systemic factors – Sex Hormones – Genetic Susceptibility – Racial Differences – Gender – Metabolic/Endocrine disorders Osteoarthritis • Local Factors – Weight – Injury – Occupation – Developmental Abnormalities – Other local factors • Strength of the lesser quadriceps • Knee laxity • Damage to other local cartilage Adapted from www.arthritis.org Provided by S Chubinskaya
  4. 4. Classification of OA • Primary (Idiopathic) – Peripheral Joints – Spine – Subsets – Hereditary • Secondary – Trauma – Underlying Joint disorders – Systemic Metabolic disorders – Crystal deposition disease – Neuropathic disorders (Charcot joints) – Miscellaneous Adapted from: Sharma & Kapoor “Epidemiology of Osteoarthritis” In: Osteoarthritis, 4th Ed. 2007 Provided by S Chubinskaya
  5. 5. Occupations Associated with OA • Knee Miners Dockers Physical Education Teachers Male Athletes Concrete Workers Painters Shipyard Workers Nuns • Ankle Ballet Dancers Soccer Players From slide collection of Drs. Kuettner and Cole Rush University Medical Center Provided by S Chubinskaya
  6. 6. Definition of OA for Epidemiologic StudyDefinition of OA for Epidemiologic Study (Rely upon radiographic definitions of OA)(Rely upon radiographic definitions of OA) • Symptomatic, radiographic OA has been defined by a radiographic criterion coupled with a positive response to a questions, e.g., pain, in that joint, on most days of a month within the preceding year Adapted from: Sharma & Kapoor “Epidemiology of Osteoarthritis” In: Osteoarthritis, 4th Ed. 2007
  7. 7. Prevalence of OA among joints • High – Hand • DIP joint • PIP joint • CMC joint of the thumb – Cervical Spine – Lumbosacral spine – Hip – Knees – First MTP joint • Low – Ankle – Wrist – Elbow – Shoulder Adapted from: Felson “Epidemiology of Osteoarthritis: prevalence and risk factors” In: Osteoarthritic Disorders, Kuettner & Goldberg, Eds.1995.
  8. 8. From slide collection of Drs. Kuettner and Cole Rush University Medical Center Provided by S Chubinskaya
  9. 9. Prevalence of OA vs RA From slide collection of Drs. Kuettner and Cole Rush University Medical Center Provided by S Chubinskaya
  10. 10. Provided by S Chubinskaya
  11. 11. 0.00% 10.00% 20.00% 30.00% 40.00% 50.00% 60.00% 70.00% 80.00% <50 65< Age Prevalence of OA with Age Hand OA Hip or Knee OA Tibiofemoral Joint DIP Adapted from: Felson “Epidemiology of Osteoarthritis: prevalence and risk factors” In: Osteoarthritic Disorders, Kuettner & Goldberg, Eds.1995. Provided by S Chubinskaya

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