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Potential sites for kinetic drug-drug interactions

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Potential sites for kinetic drug-drug interactions

  1. 1. Potential sites for kinetic drug-drug interactions Provided by Patrick du Souich gut Epithelial cell Hepatocyte P450 UGT P450 UGT Absorption/First pass Biotransformation Distribution Tubular secretion Plasma protein binding bile MDR1 MRP OATP, OAT, OCT MRP P450 UGT MDR1 DRUG Plasma protein binding Provided by Patrick du Souich

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