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Biomarkers in asthma: do they have already implications to therapy?

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Biomarkers in asthma: do they have already implications to therapy?

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Biomarkers in asthma: do they have already implications to therapy?

  1. 1. Biomarkers in asthma: do they have already implications to therapy? Ebymar Arismendi MD,MsC,PhD CIBERES-Hospital Clínic de Barcelona BRN Biomarkers in Respiratory Disease Barcelona, may 9th of 2019
  2. 2. Biomarkers in asthma Fricker M et al. Respirology 2017; 22:430-442
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  4. 4. Woodruff P et al. AJRCCM 2009; 180:388-395
  5. 5. Woodruff P et al. AJRCCM 2009; 180:388-395 * * * * * *
  6. 6. Charriot J et al. Eur Respir Rev 2016; 25:77-92
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  8. 8. Biomarkers in asthma Fricker M et al. Respirology 2017; 22:430-442
  9. 9. Price D et al. Lancet Respir J 2015 Eosinophils
  10. 10. Impact of inhaled corticosteroids on blood eosinophils Lommatzsch M, et al. Thorax 2019; 74:417-18
  11. 11. Eosinophils & response to omalizumab Casale TB, et al. Allergy 2018; 73:490-497 ≥300 eosinophils
  12. 12. Eosinophils & response to omalizumab Casale TB, et al. Allergy 2018; 73:490-497
  13. 13. Eosinophils & response to anti IL5 Varricchi G et al. Curr Opin Allergy Clin Immunol 2016, 16:186–200
  14. 14. Indirect comparisons Busse W et al. J Allergy Clin Immunol 2019;143:190-200 Exacerbations
  15. 15. Indirect comparisons Busse W et al. J Allergy Clin Immunol 2019;143:190-200 Symptoms (ACQ)
  16. 16. Froidure A et al. Eur Respir J 2016; 47:304-17 IgE
  17. 17. Strunk R et al. N Engl J Med 2006; 354:2689-95 Omalizumab IgE Body weight
  18. 18. FeNO with Omalizumab Hanania NA et al. Am J Respir Crit Care Med 2013; 187:804-11 FeNO
  19. 19. Biomarkers in asthma Fricker M et al. Respirology 2017; 22:430-442
  20. 20. Precision medicine… personalized medicine
  21. 21. earismen@clinic.cat Thanks

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