SlideShare a Scribd company logo
1 of 21
Biomarkers in asthma: do they have
already implications to therapy?
Ebymar Arismendi MD,MsC,PhD
CIBERES-Hospital Clínic de Barcelona
BRN Biomarkers in Respiratory Disease
Barcelona, may 9th of 2019
Biomarkers in asthma
Fricker M et al. Respirology 2017; 22:430-442
Wenzel S et al. AJRCCM 1999; 160:1001-1008
Woodruff P et al. AJRCCM 2009; 180:388-395
Woodruff P et al. AJRCCM 2009; 180:388-395
*
*
*
*
*
*
Charriot J et al. Eur Respir Rev 2016; 25:77-92
McCraken J et al. JAMA 2017; 318 (3):279-290
Biomarkers in asthma
Fricker M et al. Respirology 2017; 22:430-442
Price D et al. Lancet Respir J 2015
Eosinophils
Impact of inhaled corticosteroids on blood eosinophils
Lommatzsch M, et al. Thorax 2019; 74:417-18
Eosinophils & response to omalizumab
Casale TB, et al. Allergy 2018; 73:490-497
≥300 eosinophils
Eosinophils & response to omalizumab
Casale TB, et al. Allergy 2018; 73:490-497
Eosinophils & response to anti IL5
Varricchi G et al. Curr Opin Allergy Clin Immunol 2016, 16:186–200
Indirect comparisons
Busse W et al. J Allergy Clin Immunol 2019;143:190-200
Exacerbations
Indirect comparisons
Busse W et al. J Allergy Clin Immunol 2019;143:190-200
Symptoms (ACQ)
Froidure A et al. Eur Respir J 2016; 47:304-17
IgE
Strunk R et al. N Engl J Med 2006; 354:2689-95
Omalizumab
IgE
Body weight
FeNO with Omalizumab
Hanania NA et al. Am J Respir Crit Care Med 2013; 187:804-11
FeNO
Biomarkers in asthma
Fricker M et al. Respirology 2017; 22:430-442
Precision medicine… personalized medicine
earismen@clinic.cat
Thanks

More Related Content

More from brnmomentum

03 Jessé_Afrontando el uso de biomarcadores en la consulta de EPOC más allá d...
03 Jessé_Afrontando el uso de biomarcadores en la consulta de EPOC más allá d...03 Jessé_Afrontando el uso de biomarcadores en la consulta de EPOC más allá d...
03 Jessé_Afrontando el uso de biomarcadores en la consulta de EPOC más allá d...brnmomentum
 
02_Sara Martí_El microbioma en el paciente con patología grave de la vía aérea
02_Sara Martí_El microbioma en el paciente con patología grave de la vía aérea02_Sara Martí_El microbioma en el paciente con patología grave de la vía aérea
02_Sara Martí_El microbioma en el paciente con patología grave de la vía aéreabrnmomentum
 
01_Faner_Condicionantes genéticos en el desarrollo de EPOC: "Young COPD"
01_Faner_Condicionantes genéticos en el desarrollo de EPOC: "Young COPD"01_Faner_Condicionantes genéticos en el desarrollo de EPOC: "Young COPD"
01_Faner_Condicionantes genéticos en el desarrollo de EPOC: "Young COPD"brnmomentum
 
05_Ausín_Monitorización del tratamiento con fármacos biológicos en asma grave
05_Ausín_Monitorización del tratamiento con fármacos biológicos en asma grave05_Ausín_Monitorización del tratamiento con fármacos biológicos en asma grave
05_Ausín_Monitorización del tratamiento con fármacos biológicos en asma gravebrnmomentum
 
04_Muñoz_Impacto de la contaminación en el asma: estudio comparativo de pobla...
04_Muñoz_Impacto de la contaminación en el asma: estudio comparativo de pobla...04_Muñoz_Impacto de la contaminación en el asma: estudio comparativo de pobla...
04_Muñoz_Impacto de la contaminación en el asma: estudio comparativo de pobla...brnmomentum
 
03_Domingo_Sesión de formación. Presente y futuro en el manejo del asma grave...
03_Domingo_Sesión de formación. Presente y futuro en el manejo del asma grave...03_Domingo_Sesión de formación. Presente y futuro en el manejo del asma grave...
03_Domingo_Sesión de formación. Presente y futuro en el manejo del asma grave...brnmomentum
 
02_Elena Curto_Asma no T2
02_Elena Curto_Asma no T202_Elena Curto_Asma no T2
02_Elena Curto_Asma no T2brnmomentum
 
01_Bobolea_Precision Medicina in Eosinophilic Asthma: an interdisciplinaryu a...
01_Bobolea_Precision Medicina in Eosinophilic Asthma: an interdisciplinaryu a...01_Bobolea_Precision Medicina in Eosinophilic Asthma: an interdisciplinaryu a...
01_Bobolea_Precision Medicina in Eosinophilic Asthma: an interdisciplinaryu a...brnmomentum
 
05 BRN Research Forum BRN Bronquiectasias. Conclusiones por Esther Barreiro
05 BRN Research Forum BRN Bronquiectasias. Conclusiones por Esther Barreiro05 BRN Research Forum BRN Bronquiectasias. Conclusiones por Esther Barreiro
05 BRN Research Forum BRN Bronquiectasias. Conclusiones por Esther Barreirobrnmomentum
 
04 BRN Research Forum Bronquiectasias. Parte IV por David de la Rosa
04 BRN Research Forum Bronquiectasias. Parte IV por David de la Rosa04 BRN Research Forum Bronquiectasias. Parte IV por David de la Rosa
04 BRN Research Forum Bronquiectasias. Parte IV por David de la Rosabrnmomentum
 
03 BRN Research Forum Bronquiectasias. Parte III por Oriol Sibila
03 BRN Research Forum Bronquiectasias. Parte III por Oriol Sibila03 BRN Research Forum Bronquiectasias. Parte III por Oriol Sibila
03 BRN Research Forum Bronquiectasias. Parte III por Oriol Sibilabrnmomentum
 
02 BRN Research Forum Bronquiectasias. Parte II por Alicia Marín
02 BRN Research Forum Bronquiectasias. Parte II por Alicia Marín02 BRN Research Forum Bronquiectasias. Parte II por Alicia Marín
02 BRN Research Forum Bronquiectasias. Parte II por Alicia Marínbrnmomentum
 
00 BRN Research Forum Bronquiectasias. Introducción por Esther Barreiro
00 BRN Research Forum Bronquiectasias. Introducción por Esther Barreiro00 BRN Research Forum Bronquiectasias. Introducción por Esther Barreiro
00 BRN Research Forum Bronquiectasias. Introducción por Esther Barreirobrnmomentum
 
5.1 Mariluz Alonso
5.1 Mariluz Alonso5.1 Mariluz Alonso
5.1 Mariluz Alonsobrnmomentum
 
4.4 M. Ángeles Rol
4.4 M. Ángeles Rol4.4 M. Ángeles Rol
4.4 M. Ángeles Rolbrnmomentum
 
4.1 Susan Redline
4.1 Susan Redline4.1 Susan Redline
4.1 Susan Redlinebrnmomentum
 
2.2 Javier Puertas
2.2 Javier Puertas2.2 Javier Puertas
2.2 Javier Puertasbrnmomentum
 

More from brnmomentum (20)

03 Jessé_Afrontando el uso de biomarcadores en la consulta de EPOC más allá d...
03 Jessé_Afrontando el uso de biomarcadores en la consulta de EPOC más allá d...03 Jessé_Afrontando el uso de biomarcadores en la consulta de EPOC más allá d...
03 Jessé_Afrontando el uso de biomarcadores en la consulta de EPOC más allá d...
 
02_Sara Martí_El microbioma en el paciente con patología grave de la vía aérea
02_Sara Martí_El microbioma en el paciente con patología grave de la vía aérea02_Sara Martí_El microbioma en el paciente con patología grave de la vía aérea
02_Sara Martí_El microbioma en el paciente con patología grave de la vía aérea
 
01_Faner_Condicionantes genéticos en el desarrollo de EPOC: "Young COPD"
01_Faner_Condicionantes genéticos en el desarrollo de EPOC: "Young COPD"01_Faner_Condicionantes genéticos en el desarrollo de EPOC: "Young COPD"
01_Faner_Condicionantes genéticos en el desarrollo de EPOC: "Young COPD"
 
05_Ausín_Monitorización del tratamiento con fármacos biológicos en asma grave
05_Ausín_Monitorización del tratamiento con fármacos biológicos en asma grave05_Ausín_Monitorización del tratamiento con fármacos biológicos en asma grave
05_Ausín_Monitorización del tratamiento con fármacos biológicos en asma grave
 
04_Muñoz_Impacto de la contaminación en el asma: estudio comparativo de pobla...
04_Muñoz_Impacto de la contaminación en el asma: estudio comparativo de pobla...04_Muñoz_Impacto de la contaminación en el asma: estudio comparativo de pobla...
04_Muñoz_Impacto de la contaminación en el asma: estudio comparativo de pobla...
 
03_Domingo_Sesión de formación. Presente y futuro en el manejo del asma grave...
03_Domingo_Sesión de formación. Presente y futuro en el manejo del asma grave...03_Domingo_Sesión de formación. Presente y futuro en el manejo del asma grave...
03_Domingo_Sesión de formación. Presente y futuro en el manejo del asma grave...
 
02_Elena Curto_Asma no T2
02_Elena Curto_Asma no T202_Elena Curto_Asma no T2
02_Elena Curto_Asma no T2
 
01_Bobolea_Precision Medicina in Eosinophilic Asthma: an interdisciplinaryu a...
01_Bobolea_Precision Medicina in Eosinophilic Asthma: an interdisciplinaryu a...01_Bobolea_Precision Medicina in Eosinophilic Asthma: an interdisciplinaryu a...
01_Bobolea_Precision Medicina in Eosinophilic Asthma: an interdisciplinaryu a...
 
05 BRN Research Forum BRN Bronquiectasias. Conclusiones por Esther Barreiro
05 BRN Research Forum BRN Bronquiectasias. Conclusiones por Esther Barreiro05 BRN Research Forum BRN Bronquiectasias. Conclusiones por Esther Barreiro
05 BRN Research Forum BRN Bronquiectasias. Conclusiones por Esther Barreiro
 
04 BRN Research Forum Bronquiectasias. Parte IV por David de la Rosa
04 BRN Research Forum Bronquiectasias. Parte IV por David de la Rosa04 BRN Research Forum Bronquiectasias. Parte IV por David de la Rosa
04 BRN Research Forum Bronquiectasias. Parte IV por David de la Rosa
 
03 BRN Research Forum Bronquiectasias. Parte III por Oriol Sibila
03 BRN Research Forum Bronquiectasias. Parte III por Oriol Sibila03 BRN Research Forum Bronquiectasias. Parte III por Oriol Sibila
03 BRN Research Forum Bronquiectasias. Parte III por Oriol Sibila
 
02 BRN Research Forum Bronquiectasias. Parte II por Alicia Marín
02 BRN Research Forum Bronquiectasias. Parte II por Alicia Marín02 BRN Research Forum Bronquiectasias. Parte II por Alicia Marín
02 BRN Research Forum Bronquiectasias. Parte II por Alicia Marín
 
00 BRN Research Forum Bronquiectasias. Introducción por Esther Barreiro
00 BRN Research Forum Bronquiectasias. Introducción por Esther Barreiro00 BRN Research Forum Bronquiectasias. Introducción por Esther Barreiro
00 BRN Research Forum Bronquiectasias. Introducción por Esther Barreiro
 
5.2 Leila
5.2 Leila5.2 Leila
5.2 Leila
 
5.1 Mariluz Alonso
5.1 Mariluz Alonso5.1 Mariluz Alonso
5.1 Mariluz Alonso
 
4.4 M. Ángeles Rol
4.4 M. Ángeles Rol4.4 M. Ángeles Rol
4.4 M. Ángeles Rol
 
4.1 Susan Redline
4.1 Susan Redline4.1 Susan Redline
4.1 Susan Redline
 
3.4 David Gozal
3.4 David Gozal3.4 David Gozal
3.4 David Gozal
 
2.3 Carlos Egea
2.3 Carlos Egea2.3 Carlos Egea
2.3 Carlos Egea
 
2.2 Javier Puertas
2.2 Javier Puertas2.2 Javier Puertas
2.2 Javier Puertas
 

Recently uploaded

Valproic Acid. (VPA). Antiseizure medication
Valproic Acid.  (VPA). Antiseizure medicationValproic Acid.  (VPA). Antiseizure medication
Valproic Acid. (VPA). Antiseizure medicationMohamadAlhes
 
Plant Fibres used as Surgical Dressings PDF.pdf
Plant Fibres used as Surgical Dressings PDF.pdfPlant Fibres used as Surgical Dressings PDF.pdf
Plant Fibres used as Surgical Dressings PDF.pdfDivya Kanojiya
 
CEHPALOSPORINS.pptx By Harshvardhan Dev Bhoomi Uttarakhand University
CEHPALOSPORINS.pptx By Harshvardhan Dev Bhoomi Uttarakhand UniversityCEHPALOSPORINS.pptx By Harshvardhan Dev Bhoomi Uttarakhand University
CEHPALOSPORINS.pptx By Harshvardhan Dev Bhoomi Uttarakhand UniversityHarshChauhan475104
 
PNEUMOTHORAX AND ITS MANAGEMENTS.pdf
PNEUMOTHORAX   AND  ITS  MANAGEMENTS.pdfPNEUMOTHORAX   AND  ITS  MANAGEMENTS.pdf
PNEUMOTHORAX AND ITS MANAGEMENTS.pdfDolisha Warbi
 
SCHOOL HEALTH SERVICES.pptx made by Sapna Thakur
SCHOOL HEALTH SERVICES.pptx made by Sapna ThakurSCHOOL HEALTH SERVICES.pptx made by Sapna Thakur
SCHOOL HEALTH SERVICES.pptx made by Sapna ThakurSapna Thakur
 
Exploring the Variety of Private Blood Tests in the UK
Exploring the Variety of Private Blood Tests in the UKExploring the Variety of Private Blood Tests in the UK
Exploring the Variety of Private Blood Tests in the UKPrivate GP London
 
SHOCK (Medical SURGICAL BASED EDITION)).pptx
SHOCK (Medical SURGICAL BASED EDITION)).pptxSHOCK (Medical SURGICAL BASED EDITION)).pptx
SHOCK (Medical SURGICAL BASED EDITION)).pptxAbhishek943418
 
Biomechanics- Shoulder Joint!!!!!!!!!!!!
Biomechanics- Shoulder Joint!!!!!!!!!!!!Biomechanics- Shoulder Joint!!!!!!!!!!!!
Biomechanics- Shoulder Joint!!!!!!!!!!!!ibtesaam huma
 
Rheumatoid arthritis - Musculoskeletal disorders.ppt
Rheumatoid arthritis - Musculoskeletal disorders.pptRheumatoid arthritis - Musculoskeletal disorders.ppt
Rheumatoid arthritis - Musculoskeletal disorders.pptraviapr7
 
Tans femoral Amputee : Prosthetics Knee Joints.pptx
Tans femoral Amputee : Prosthetics Knee Joints.pptxTans femoral Amputee : Prosthetics Knee Joints.pptx
Tans femoral Amputee : Prosthetics Knee Joints.pptxKezaiah S
 
The next social challenge to public health: the information environment.pptx
The next social challenge to public health:  the information environment.pptxThe next social challenge to public health:  the information environment.pptx
The next social challenge to public health: the information environment.pptxTina Purnat
 
ANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
ANEMIA IN PREGNANCY by Dr. Akebom KidanemariamANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
ANEMIA IN PREGNANCY by Dr. Akebom KidanemariamAkebom Gebremichael
 
Musculoskeletal disorders: Osteoarthritis,.pptx
Musculoskeletal disorders: Osteoarthritis,.pptxMusculoskeletal disorders: Osteoarthritis,.pptx
Musculoskeletal disorders: Osteoarthritis,.pptxraviapr7
 
PULMONARY EDEMA AND ITS MANAGEMENT.pdf
PULMONARY EDEMA AND  ITS  MANAGEMENT.pdfPULMONARY EDEMA AND  ITS  MANAGEMENT.pdf
PULMONARY EDEMA AND ITS MANAGEMENT.pdfDolisha Warbi
 
Basic principles involved in the traditional systems of medicine PDF.pdf
Basic principles involved in the traditional systems of medicine PDF.pdfBasic principles involved in the traditional systems of medicine PDF.pdf
Basic principles involved in the traditional systems of medicine PDF.pdfDivya Kanojiya
 
Presentation on Parasympathetic Nervous System
Presentation on Parasympathetic Nervous SystemPresentation on Parasympathetic Nervous System
Presentation on Parasympathetic Nervous SystemPrerana Jadhav
 
Aditi Jagtap (Daughter of Ranjit Jagtap).pdf
Aditi Jagtap (Daughter of Ranjit Jagtap).pdfAditi Jagtap (Daughter of Ranjit Jagtap).pdf
Aditi Jagtap (Daughter of Ranjit Jagtap).pdfAditi Jagtap Pune
 
SGK HÓA SINH NĂNG LƯỢNG SINH HỌC 2006.pdf
SGK HÓA SINH NĂNG LƯỢNG SINH HỌC 2006.pdfSGK HÓA SINH NĂNG LƯỢNG SINH HỌC 2006.pdf
SGK HÓA SINH NĂNG LƯỢNG SINH HỌC 2006.pdfHongBiThi1
 
VarSeq 2.6.0: Advancing Pharmacogenomics and Genomic Analysis
VarSeq 2.6.0: Advancing Pharmacogenomics and Genomic AnalysisVarSeq 2.6.0: Advancing Pharmacogenomics and Genomic Analysis
VarSeq 2.6.0: Advancing Pharmacogenomics and Genomic AnalysisGolden Helix
 
Introduction to Sports Injuries by- Dr. Anjali Rai
Introduction to Sports Injuries by- Dr. Anjali RaiIntroduction to Sports Injuries by- Dr. Anjali Rai
Introduction to Sports Injuries by- Dr. Anjali RaiGoogle
 

Recently uploaded (20)

Valproic Acid. (VPA). Antiseizure medication
Valproic Acid.  (VPA). Antiseizure medicationValproic Acid.  (VPA). Antiseizure medication
Valproic Acid. (VPA). Antiseizure medication
 
Plant Fibres used as Surgical Dressings PDF.pdf
Plant Fibres used as Surgical Dressings PDF.pdfPlant Fibres used as Surgical Dressings PDF.pdf
Plant Fibres used as Surgical Dressings PDF.pdf
 
CEHPALOSPORINS.pptx By Harshvardhan Dev Bhoomi Uttarakhand University
CEHPALOSPORINS.pptx By Harshvardhan Dev Bhoomi Uttarakhand UniversityCEHPALOSPORINS.pptx By Harshvardhan Dev Bhoomi Uttarakhand University
CEHPALOSPORINS.pptx By Harshvardhan Dev Bhoomi Uttarakhand University
 
PNEUMOTHORAX AND ITS MANAGEMENTS.pdf
PNEUMOTHORAX   AND  ITS  MANAGEMENTS.pdfPNEUMOTHORAX   AND  ITS  MANAGEMENTS.pdf
PNEUMOTHORAX AND ITS MANAGEMENTS.pdf
 
SCHOOL HEALTH SERVICES.pptx made by Sapna Thakur
SCHOOL HEALTH SERVICES.pptx made by Sapna ThakurSCHOOL HEALTH SERVICES.pptx made by Sapna Thakur
SCHOOL HEALTH SERVICES.pptx made by Sapna Thakur
 
Exploring the Variety of Private Blood Tests in the UK
Exploring the Variety of Private Blood Tests in the UKExploring the Variety of Private Blood Tests in the UK
Exploring the Variety of Private Blood Tests in the UK
 
SHOCK (Medical SURGICAL BASED EDITION)).pptx
SHOCK (Medical SURGICAL BASED EDITION)).pptxSHOCK (Medical SURGICAL BASED EDITION)).pptx
SHOCK (Medical SURGICAL BASED EDITION)).pptx
 
Biomechanics- Shoulder Joint!!!!!!!!!!!!
Biomechanics- Shoulder Joint!!!!!!!!!!!!Biomechanics- Shoulder Joint!!!!!!!!!!!!
Biomechanics- Shoulder Joint!!!!!!!!!!!!
 
Rheumatoid arthritis - Musculoskeletal disorders.ppt
Rheumatoid arthritis - Musculoskeletal disorders.pptRheumatoid arthritis - Musculoskeletal disorders.ppt
Rheumatoid arthritis - Musculoskeletal disorders.ppt
 
Tans femoral Amputee : Prosthetics Knee Joints.pptx
Tans femoral Amputee : Prosthetics Knee Joints.pptxTans femoral Amputee : Prosthetics Knee Joints.pptx
Tans femoral Amputee : Prosthetics Knee Joints.pptx
 
The next social challenge to public health: the information environment.pptx
The next social challenge to public health:  the information environment.pptxThe next social challenge to public health:  the information environment.pptx
The next social challenge to public health: the information environment.pptx
 
ANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
ANEMIA IN PREGNANCY by Dr. Akebom KidanemariamANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
ANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
 
Musculoskeletal disorders: Osteoarthritis,.pptx
Musculoskeletal disorders: Osteoarthritis,.pptxMusculoskeletal disorders: Osteoarthritis,.pptx
Musculoskeletal disorders: Osteoarthritis,.pptx
 
PULMONARY EDEMA AND ITS MANAGEMENT.pdf
PULMONARY EDEMA AND  ITS  MANAGEMENT.pdfPULMONARY EDEMA AND  ITS  MANAGEMENT.pdf
PULMONARY EDEMA AND ITS MANAGEMENT.pdf
 
Basic principles involved in the traditional systems of medicine PDF.pdf
Basic principles involved in the traditional systems of medicine PDF.pdfBasic principles involved in the traditional systems of medicine PDF.pdf
Basic principles involved in the traditional systems of medicine PDF.pdf
 
Presentation on Parasympathetic Nervous System
Presentation on Parasympathetic Nervous SystemPresentation on Parasympathetic Nervous System
Presentation on Parasympathetic Nervous System
 
Aditi Jagtap (Daughter of Ranjit Jagtap).pdf
Aditi Jagtap (Daughter of Ranjit Jagtap).pdfAditi Jagtap (Daughter of Ranjit Jagtap).pdf
Aditi Jagtap (Daughter of Ranjit Jagtap).pdf
 
SGK HÓA SINH NĂNG LƯỢNG SINH HỌC 2006.pdf
SGK HÓA SINH NĂNG LƯỢNG SINH HỌC 2006.pdfSGK HÓA SINH NĂNG LƯỢNG SINH HỌC 2006.pdf
SGK HÓA SINH NĂNG LƯỢNG SINH HỌC 2006.pdf
 
VarSeq 2.6.0: Advancing Pharmacogenomics and Genomic Analysis
VarSeq 2.6.0: Advancing Pharmacogenomics and Genomic AnalysisVarSeq 2.6.0: Advancing Pharmacogenomics and Genomic Analysis
VarSeq 2.6.0: Advancing Pharmacogenomics and Genomic Analysis
 
Introduction to Sports Injuries by- Dr. Anjali Rai
Introduction to Sports Injuries by- Dr. Anjali RaiIntroduction to Sports Injuries by- Dr. Anjali Rai
Introduction to Sports Injuries by- Dr. Anjali Rai
 

Biomarkers in asthma: do they have already implications to therapy?