Biomarkers in asthma: do they have already implications to therapy?

1. Biomarkers in asthma: do they have
already implications to therapy?
Ebymar Arismendi MD,MsC,PhD
CIBERES-Hospital Clínic de Barcelona
BRN Biomarkers in Respiratory Disease
Barcelona, may 9th of 2019

2. Biomarkers in asthma
Fricker M et al. Respirology 2017; 22:430-442

3. Wenzel S et al. AJRCCM 1999; 160:1001-1008

4. Woodruff P et al. AJRCCM 2009; 180:388-395

5. Woodruff P et al. AJRCCM 2009; 180:388-395
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6. Charriot J et al. Eur Respir Rev 2016; 25:77-92

7. McCraken J et al. JAMA 2017; 318 (3):279-290

8. Biomarkers in asthma
Fricker M et al. Respirology 2017; 22:430-442

9. Price D et al. Lancet Respir J 2015
Eosinophils

10. Impact of inhaled corticosteroids on blood eosinophils
Lommatzsch M, et al. Thorax 2019; 74:417-18

11. Eosinophils & response to omalizumab
Casale TB, et al. Allergy 2018; 73:490-497
≥300 eosinophils

12. Eosinophils & response to omalizumab
Casale TB, et al. Allergy 2018; 73:490-497

13. Eosinophils & response to anti IL5
Varricchi G et al. Curr Opin Allergy Clin Immunol 2016, 16:186–200

14. Indirect comparisons
Busse W et al. J Allergy Clin Immunol 2019;143:190-200
Exacerbations

15. Indirect comparisons
Busse W et al. J Allergy Clin Immunol 2019;143:190-200
Symptoms (ACQ)

16. Froidure A et al. Eur Respir J 2016; 47:304-17
IgE

17. Strunk R et al. N Engl J Med 2006; 354:2689-95
Omalizumab
IgE
Body weight

18. FeNO with Omalizumab
Hanania NA et al. Am J Respir Crit Care Med 2013; 187:804-11
FeNO

19. Biomarkers in asthma
Fricker M et al. Respirology 2017; 22:430-442

20. Precision medicine… personalized medicine

21. earismen@clinic.cat
Thanks