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Nanoracks LLC

Webinar in Support of NSF Solicitation NSF 19-509

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Nanoracks LLC

  1. 1. Your Commercial Research Lab (In Space!) Introducing NanoRacks’ Next Generation Capabilities Aboard the International Space Station Carl Carruthers, Jr., Ph.D., Chief Scientist NanoRacks LLC | NanoRacks LLC - For Public Distribution 1
  2. 2. NanoRacks LLC - For Public Distribution 2 Over 700 payloads delivered to the ISS
  3. 3. NanoRacks LLC - For Public Distribution 3
  4. 4. MixStix • Mixture enclosure tubes for fluids, materials, chemicals, biological materials – and keeping them separate until you are ready to mix in space! • Single, double, or triple experiment sample segments • Activated by astronaut crew on board • 10 ml parylene coated silicon tubes • Can be stowed frozen (-20C), cold (+4C), or ambient on lauch, berth, pre & post operations, and on return • Most common with younger educational groups, but we have seen some advanced research leveraging MixStix NanoRacks LLC - For Public Distribution 4
  5. 5. NanoLabs – The Original Plug and Play • A NanoLab is a Module that houses a science experiment to be run on the station! • Interface NanoRacks Platforms 1&2 • Generally 1.5U (10x10x15cm) in size • Can be as large as 4x2U • Powered through USB 2.0 5V • “Plug-n-Play” – plugged in by an astronaut and they’re ready to go! • Can be operated external to the rack for an additional fee. NanoRacks LLC - For Public Distribution 5
  6. 6. What can you do with a NanoLab? NanoRacks LLC - For Public Distribution 6
  7. 7. NanoRacks Platform 1 & 2/2B Overview NanoRacks LLC - For Public Distribution 7
  8. 8. NanoRacks Frame 3 • Designed for higher powered payloads 3 bays with multiple power options (50W maximum) • Up to 4U in size • Provide standard data transfer capabilities NanoRacks LLC - For Public Distribution 8
  9. 9. Black Box • Designed to accommodate autonomous payloads while providing advanced science capabilities for researches • Providing near-launch payload handover • Locker-sized platform that accommodates up to 18U of payloads • NanoLab style research, robotics, automated MixStix, and more! NanoRacks LLC - For Public Distribution 9
  10. 10. NanoRacks Frame vs. Black Box Black Box • Ideal for advanced, professional research • Higher power – 28V • Customizable power opportunities • High quantity of experiments at once • First customer mission held 6 NanoLab units holding 18 different experiments • Dedicated customer mission – reserve the full Black Box! • Research privacy • No interaction with other customer payloads or astronaut crew • Integrated into flight unit on the ground NanoRacks Frame • Plug and Play NanoLabs • Ideal for educational, basic research • USB 2.0 and 3.0 power availability • Better temperature profile • Astronaut activation of experiments • Photo opportunities of hardware on orbit • Video footage of astronaut installation and interaction NanoRacks LLC - For Public Distribution 10
  11. 11. NanoRacks Plate Reader-2 • Utilizing the same core hardware: Molecular Devices SpectraMax M5e • Upgraded capabilities include: • New Computer • Redesigned Ventilation System for thermal control • KU Forward Wireless/Wired used to communicate directly with ground ops • Full spectral range detection for 6, 12, 24, 48, 96, and 384 well microplates • Can use the Cuvette Plate microplate adaptor for cuvette samples • Launched on SpaceX-9 and installed by Astronaut Kate Rubins – we’re open for business! NanoRacks LLC - For Public Distribution 11
  12. 12. NanoRacks and BioServe: Plate Reader-2 & BioCells • BioServe BioCell plates fit in the NanoRacks Plater Reader-2 • 6 or single well • BioCells support suspension or adherent cells • Gas exchange through membrane • Inlet and outlet ports for sample/media exchanges NanoRacks LLC - For Public Distribution 12
  13. 13. Reactor Microplates • Numerous chemistry applications for advanced microgravity research • Designed to allow a reaction to not occur until the experiment is ready to be activated on orbit • NanoRacks upgraded microplate design for microgravity allows for increased mixing between chambers, few bubbles, more readings per window, and easier assembly • 4 sets of 2x chambers NanoRacks LLC - For Public Distribution 13
  14. 14. Contracting with NanoRacks • NanoRacks offers multiple avenues to secure contracting – from direct commercial opportunities to government (services contract) to educational contracting. • Our easy contracting processes are available for everything from passive MixStix to hosted Airlock payloads • Contracting available for launching COTS hardware – beyond just research experiments • New contracting opportunities available soon – come talk to us for more information NanoRacks LLC - For Public Distribution 14
  15. 15. From Research to Business NanoRacks is proud to share that two organizations that started with initial microgravity research utilizing our platforms have formed into commercial companies! NanoRacks LLC - For Public Distribution 15
  16. 16. Sampling of Published Research Using NanoRacks Hardware • "NanoRocks: Design and performance of an experiment studying planet formation on the International Space Station.” Brisset J, Colwell J, Dove A, Maukonen D. Rev Sci Instrum. 2017 Jul;88(7):074502. doi: 10.1063/1.4991857.PMID: 28764536 • “A Hitchhiker’s Guide to an ISS Experiment in under 9 Months .” Nadir, Andrei James. NPJ Microgravity 3 (2017): 6. PMC. Web. 20 Oct. 2017. • “Cytoskeletal stability and metabolic alterations in primary human macrophages in long-term microgravity." Tauber S, Lauber BA, Paulsen K, Layer LE, Lehmann M, Hauschild S, Shepherd NR, Polzer J, Segerer J, Thiel CS, Ullrich O. PLoS One. 2017 Apr 18;12(4):e0175599. doi: 10.1371/journal.pone.0175599. eCollection 2017. PMID: 28419128 • "Growth of 48 built environment bacterial isolates on board the International Space Station (ISS)." Coil, D. A., Neches, R. Y., Lang, J. M., Brown, W. E., Severance, M., Cavalier, D., & Eisen, J. A. (2016). PeerJ, 4, e1842. • “"The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions." Riwaldt S, Bauer J, Pietsch J, Braun M, Segerer J, Schwarzwälder A, Corydon TJ, Infanger M, Grimm D.Int J Mol Sci. 2015 Nov 30;16(12):28296-310. doi: 10.3390/ijms161226108.PMID: 26633361 • "A microfluidic, high throughput protein crystal growth method for microgravity." Carruthers CW Jr, Gerdts C, Johnson MD, Webb P. PLoS One. 2013 Nov 21;8(11):e82298. doi: 10.1371/journal.pone.0082298. eCollection 2013.PMID: 24278480 • "Evaluation of the Fluids Mixing Enclosure System for Life Science Experiments During a Commercial Caenorhabditis elegans Spaceflight Experiment." Warren P, Golden A, Hanover J, Love D, Shephard F, Szewczyk NJ. Adv Space Res. 2013 Jun 1;51(12):2241-2250.PMID: 23794777 NanoRacks LLC - For Public Distribution 16
  17. 17. Your Commercial Research Lab (In Space!) Introducing NanoRacks’ Next Generation Capabilities Aboard the International Space Station NanoRacks LLC - For Public Distribution 17 Carl Carruthers, Jr., Ph.D., Chief Scientist NanoRacks LLC |