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immature
osteoblast
prehypertrophic
chondrocyte
early
chondrocyte perichondrium
mesenchymal
progenitor
mature
osteoblast
S...
Postnatal inactivation of Sox9 results within 10 days in early osteoarthritic features, i.e.,
loss of Safranin’O staining ...
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Transcription Factor Sox9

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Transcription Factor Sox9

  1. 1. immature osteoblast prehypertrophic chondrocyte early chondrocyte perichondrium mesenchymal progenitor mature osteoblast Sox9 Sox9 Sox9 articular chondrocyte joint mesenchyme Sox9 Sox9 Sox9 columnar chondrocyte hypertrophic chondrocyte terminal chondrocyte Sox9 growth plate cartilage articular cartilage cartilage primordia Provided by: Veronique Lefebvre, PhDProvided by: Veronique Lefebvre, PhD
  2. 2. Postnatal inactivation of Sox9 results within 10 days in early osteoarthritic features, i.e., loss of Safranin’O staining (red), decreased height, and rough surface of knee articular cartilage Sox9fl/fl (control) Sox9fl/flATC (mutant) control mutant femur tibia Sox9 is necessary for articular cartilage maintenance Sox9 is necessary for growth plate cartilage development Sox9 protein outlives its RNA in pre/hypertrophic chondrocytes and its inactivation in the fetal growth plate results within 3 days in a short columnar zone and in lack of hypertrophic zone due to differentiation of prehypertrophic chondrocytes into osteoblasts. Sox9fl/ fl (contro l) Sox9fl/ fl ATC (mutan t) femur tibia Provided by: Veronique Lefebvre, PhD

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