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THE Na-K ATPase PumpAction Potential in a Neuron part 2: Na-K ATPase Pump. Rricketson11.16.2012                Copyright ©...
THE RESTING POTENTIALResting potential (EK )refers tothe difference between thevoltage inside and outside theneuron when n...
THE RESTING POTENTIAL-THE NA-K ATPASE PUMPThe Na+/K+-ATPase pump helps maintain membrane  potential.   Moves 3 sodium ion...
THE RESTING POTENTIAL-THE NA-K ATPASE PUMPMechanism (PDB ID 2B8E, 2ZKE    biological assembly)                            ...
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Action potential in a neuron: Na-K ATPase pump interactive2

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Action potential in a neuron: Na-K ATPase pump interactive2

  1. 1. THE Na-K ATPase PumpAction Potential in a Neuron part 2: Na-K ATPase Pump. Rricketson11.16.2012 Copyright © 2012 Seaspine. All rights reserved. 1
  2. 2. THE RESTING POTENTIALResting potential (EK )refers tothe difference between thevoltage inside and outside theneuron when not propagating an Cl-impulse. The resting potential of K+the average neuron is around -70 Na+mVT The inside of the cell is 70 Na+mV less than the outside of the Na+cell. Na+ K+ Na+ K+ K+ Cl- K+
  3. 3. THE RESTING POTENTIAL-THE NA-K ATPASE PUMPThe Na+/K+-ATPase pump helps maintain membrane potential. Moves 3 sodium ions out and 2 potassium ions in, (removes 1 + charge) against concentration gradient Responsible for up to 2/3 of the neuron’s energy expenditure. 3
  4. 4. THE RESTING POTENTIAL-THE NA-K ATPASE PUMPMechanism (PDB ID 2B8E, 2ZKE biological assembly) K+ K+ Unphosphorylated form binds 3 intracellular Na+ ions while binding ATP Hydrolysis of ATP  ADP + Phosphorylation of the pump at a highly conserved Aspartate residue; ADP + Pi. Phosphorylated form has a low affinity for Na+  Release Pump binds 2 extracellular K+ ions  Dephosphorylation. Dephosphorylation high affinity for Na+ ions. K+ (2)  Released Na+ K+ ions are transported into the cell. Na+ Na+ 4
  5. 5. THANK YOU 5

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