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Transport Of Oxygen 2


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Transport Of Oxygen 2

  1. 1. Transport of Oxygen 2 The Bohr effect Fetal haemoglobin Myoglobin
  2. 2. Transport of Oxygen 2 <ul><li>Hb is even more efficient that suggested by the dissociation curve </li></ul><ul><li>The amount of O 2 carried by Hb depends not only on the p O 2 but also the partial pressure of carbon dioxide . </li></ul>
  3. 3. Transport of Oxygen 2 <ul><li>At the tissues there is high [carbon dioxide] this reduces Hb affinity for oxygen so it gives it up. </li></ul><ul><li>Conversely at lungs there is low [carbon dioxide] so the Hb has a greater affinity for oxygen – so picks up more. </li></ul>
  4. 5. <ul><li>The result is thus, that under the same blood pO 2 conditions, high levels of CO 2 (acidic conditions) will unload more O 2 from the Hb </li></ul><ul><li>Oxyhaemoglobin releases its oxygen where it is most needed: to the actively respiring tissues. </li></ul>Transport of Oxygen 2
  5. 6. Transport of Oxygen 2 <ul><li>The further the dissociation curve moves to the right, the more readily Hb gives up its oxygen. </li></ul>
  6. 7. Transport of Oxygen 2 <ul><li>The further the dissociation curve moves to the left, the more readily Hb picks up oxygen. </li></ul>
  7. 8. Fetal haemoglobin <ul><li>The developing fetus obtains oxygen from its mum </li></ul><ul><li>Fetal and maternal blood run close together but never mix </li></ul><ul><li>This allows materials to diffuse from the blood of mum into the fetus and vice versa. . </li></ul>
  8. 9. Fetal haemoglobin
  9. 10. Fetal haemoglobin <ul><li>The dissociation curve of fetal Hb is to the left of adult Hb </li></ul><ul><li>This means fetal Hb combines with oxygen more readily than adult Hb </li></ul><ul><li>Fetal Hb has a higher affinity for oxygen. </li></ul>
  10. 11. Fetal haemoglobin <ul><li>At the placenta the fetal haemoglobin can ‘steal’ oxygen form the maternal haemoglobin. </li></ul>
  11. 12. Myoglobin <ul><li>In muscle there is another oxygen binding molecule called myoglobin . </li></ul><ul><li>Oxymyoglobin is much more stable than oxyhaemoglobin </li></ul>
  12. 13. Myoglobin <ul><li>Myoglobin will only give up its oxygen at very low oxygen partial pressures. </li></ul>
  13. 15. Myoglobin <ul><li>The myoglobin dissociation curve is a long way to the left of Hb. </li></ul><ul><li>At each partial pressure of oxygen, myoglobin holds onto much more oxygen than Hb. </li></ul>
  14. 16. Myoglobin <ul><li>This enables myoglobin to act as an oxygen store. </li></ul><ul><li>Usually respiring muscle will get its oxygen from oxyhaemoglobin </li></ul><ul><li>Only if the partial pressure of oxygen falls very low will oxymyoglobin release its oxygen </li></ul>