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Lesson 11 Gene Therapy


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gene therapy

Published in: Technology, Health & Medicine

Lesson 11 Gene Therapy

  1. 1. Gene Therapy. To understand how gene therapy may make it possible to treat certain genetic disorders
  2. 2. Finding a new treatment for Cystic Fibrosis. <ul><li>The cell nuclei of Cystic Fibrosis patients contain 2 faulty recessive alleles. </li></ul><ul><li>One of the proteins the cells make is faulty. The faulty protein causes the Cystic Fibrosis Symptoms </li></ul><ul><li>Some scientists have been trying to develop a new treatment for Cystic Fibrosis. Their plan is to put copies of the normal allele into the cells of CF patients. </li></ul><ul><li>This kind of treatment is called Gene Therapy. </li></ul>
  3. 3. Chromosome 7 CF Allele Find the CF Allele on a human chromosome. Use chromosomes from someone without CF. Cut out the normal alleles. Make lots of copies Put these copies into cells of the CF patients - (Gene Modification)
  4. 4. <ul><li>Draw a flow chart to explain gene therapy. </li></ul><ul><li>Some of the CF sufferers were better for a while, unfortunately the improvements didn’t last. Why? </li></ul><ul><li>Future possibilities </li></ul><ul><li>In the future it may be possible to use gene therapy to prevent known genetic diseases. </li></ul><ul><li>New genes could be put into the sex cells or fertilised egg cells. All the new person’s cells would have the correct versions of their faulty genes. </li></ul><ul><li>At the moment gene therapy of sex cells is illegal. Why? </li></ul>
  5. 5. <ul><li>Gene therapy in the news </li></ul><ul><li>Lots of people’s opinion appear in the media. But not everything written down in black and white is the truth!!!!. The media often present as fact things that are -: </li></ul><ul><li>Opinions </li></ul><ul><li>Speculations </li></ul><ul><li>Evidence </li></ul><ul><li>Explanation </li></ul><ul><li>How can you sort out the facts about an issue? </li></ul><ul><li>Match each item to the correct definition. One has been done for you. </li></ul>An idea to explain some evidence. Fact Information that is linked to the issue. Explanation Someone’s view point. May not be based on evidence. Evidence An idea most people accept because it hasn’t been disapproved. Speculation What someone thinks will happen. Usually based on some evidence. Opinion
  6. 6. Now to practise, read this passage and test your knowledge. Is Mr Briggs guilty of speeding? Sunday, March 7 th , was a cold, sunny day. At 11.36am, Mr Briggs was observed driving along Water Street. A speed camera measured his speed at 36mph. This is 6mph above the speed limit. Mr Briggs denies that he was speeding. <ul><li>What is the issue? </li></ul><ul><li>Give one fact in the passage. </li></ul><ul><li>Underline a piece evidence that is linked to this issue. </li></ul><ul><li>Draw a ring around some information that is not linked to this issue. </li></ul>
  7. 7. Gene therapy – hope for the future? Gene therapy could be soon be the magic cure for people with genetic diseases. It works by putting the corrected genes they need into the person’s cells. Gene therapy has already cured a few babies of the genetic disease SCID. Unfortunately two babies who had the treatment in France have developed serious blood diseases. This could be because of their gene therapy. Some doctors think that the new genes could affect the cells in a way we don’t yet understand. So both France and the USA have stopped their trials of gene therapy for SCID. A mother whose son was waiting for this treatment in France is very upset. ‘It was probably nothing to do with the treatment. It’s just a coincidence. There is no suitable bone marrow transplant for my baby. It’s not fair that he can’t try gene therapy,’ she said.
  8. 8. <ul><li>In the first paragraph: </li></ul><ul><li>Underline in red a description of gene therapy. </li></ul><ul><li>Underline in 2 different colours: </li></ul><ul><li>i. The fact that a few babies have been cured of SCID </li></ul><ul><li>ii. The speculation the gene therapy could soon be a cure for all genetic diseases. </li></ul><ul><li>In the second paragraph: </li></ul><ul><li>Underline in red a piece of evidence. </li></ul><ul><li>Put in a different colour an explanation. </li></ul><ul><li>In the last paragraph underline in red an opinion. </li></ul><ul><li>Is there any evidence that this opinion could be biased? </li></ul>