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Kaul.DailyAspirinUse

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A look at safe and effective Aspirin administration

Published in: Health & Medicine, Technology
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Kaul.DailyAspirinUse

  1. 1. Safe and effective Aspirin regimen
  2. 2. Indication for Use <ul><li>Anti-platelet </li></ul><ul><li>Pain </li></ul><ul><li>Fever </li></ul><ul><li>Anti-inflammatory </li></ul>
  3. 3. Effective Dose <ul><li>Minimum dose with maximum effect is 75 mg daily </li></ul><ul><li>Randomized Control Trial </li></ul><ul><li>Level of Evidence 2 </li></ul><ul><li>Second loading dose effective in AMI’s </li></ul><ul><ul><li>Gurbel et al., 2007 </li></ul></ul><ul><ul><li>Fuchs et al., 2010 </li></ul></ul>
  4. 4. Things that affect Efficacy <ul><li>Ranitidine </li></ul><ul><ul><li>Effect of ranitidine on the antiplatelet effects of aspirin in healthy human subjects. </li></ul></ul><ul><li>Level 2 </li></ul><ul><li>Randomized control study </li></ul><ul><ul><ul><li>Lev et al., 2007 </li></ul></ul></ul>
  5. 5. Thing That Affect Efficacy
  6. 6. Things That affect efficacy <ul><li>Enteric Coating </li></ul><ul><ul><li>Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. </li></ul></ul><ul><ul><li>Level 2 </li></ul></ul><ul><ul><li>Randomized Control Trial </li></ul></ul><ul><ul><li>Cox et al., 2006 </li></ul></ul>
  7. 7. Contraindications <ul><li>Asthma </li></ul><ul><li>GI-Bleeding </li></ul><ul><li>Allergy </li></ul>
  8. 8. References <ul><li>Cox, D., Maree, A., Dooley, M., Conroy, R., Byrne, M., & Fitzgerald, D. (2006). Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers.  Stroke (00392499) ,  37 (8), 2153-2158. </li></ul><ul><li>Fuchs, I., Spiel, A., Frossard, M., Derhaschnig, U., Riedmüller, E., & Jilma, B. (2010). Platelet hyperfunction is decreased by additional aspirin loading in patients presenting with myocardial infarction on daily aspirin therapy.  Critical Care Medicine ,  38 (6), 1423-1429. doi:10.1097/CCM.0b013e3181de8b1e </li></ul><ul><li>Gurbel, P., Bliden, K., DiChiara, J., Newcomer, J., Weng, W., Neerchal, N., & ... Tantry, U. (2007). Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study.  Circulation ,  115 (25), 3156-3164. </li></ul><ul><li>Lev, E., Ramabadran, R., Guthikonda, S., Patel, R., Kleiman, A., Granada, J., & ... Kleiman, N. (2007). Effect of ranitidine on the antiplatelet effects of aspirin in healthy human subjects.  American Journal Of Cardiology ,  99 (1), 124-128. </li></ul><ul><li>Würtz, M., Grove, E., Kristensen, S., & Hvas, A. (2010). The antiplatelet effect of aspirin is reduced by proton pump inhibitors in patients with coronary artery disease.  Heart ,  96 (5), 368-371. doi:10.1136/hrt.2009.181107 </li></ul>

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