In 2018, the SciELO Program will celebrate 20 years of operation, in full alignment with the advances of open science. The SciELO 20 Years Conference will address and debate – during its three-day program – the main political, methodological and technological issues that define today’s state of the art in scholarly communication and the trends and innovations that is shaping the future of the universal openness of scholarly publishing and its relationship with today’s Open Access journals, in particular those of the SciELO Network. The program of the conference is organized around the alignment of SciELO journals and operations with the best practices on communication of open science, such as publishing research data, expediting editorial processes and communication through the continuous publication of articles and the adoption of preprints, maximizing the transparency of research evaluation and the flow of scholarly communication, and searching for more comprehensive systems for assessing research, articles and journals. A two-day meeting of the coordinators of the national collections of the SciELO Network will take place prior to the Conference with focus on the evaluation of SciELO journals and the SciELO Program and their improvement following the lines of action that will guide their development in the forthcoming five years. The celebration of SciELO’s 20-year anniversary constitutes an important landmark in SciELO’s evolution, and an exceptional moment to promote the advancement of an inclusive, global approach to scholarly communication and to the open access movement while respecting the diversities of thematic and geographic areas, as well as of languages of scientific research.