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The Driver of the Healthcare System in the 21st Century: Real-world Application Examples

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The slide deck of the 11th Telematics Conference on Feb 24, 2016 in Potsdam, Germany.

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The Driver of the Healthcare System in the 21st Century: Real-world Application Examples

  1. 1. The Driver of the Healthcare System in the 21st Century: Real-world Application Examples Dr. Matthieu-P. Schapranow 2016 Telematics Conference, Potsdam Feb 24, 2016
  2. 2. ■  Patients □  Individual anamnesis, family history, and background □  Require fast access to individualized therapy ■  Clinicians □  Identify root and extent of disease using laboratory tests □  Evaluate therapy alternatives, adapt existing therapy ■  Researchers □  Conduct laboratory work, e.g. analyze patient samples □  Create new research findings and come-up with treatment alternatives Healthcare Interactions in the 21st Century Schapranow, Telematics Conference, Feb 24, 2016 2 The Driver of the Healthcare System in the 21st Century
  3. 3. Healthcare Interactions in the 21st Century Schapranow, Telematics Conference, Feb 24, 2016 The Driver of the Healthcare System in the 21st Century 3 Indirect Interaction Direct Interaction C linician PatientResearcher Pharm aceutical Com pany H ealthcare Providers H ospital Research Center Laboratory Patient Advocacy G roup
  4. 4. IT Challenges Distributed Heterogeneous Data Sources 4 Human genome/biological data 600GB per full genome 15PB+ in databases of leading institutes Prescription data 1.5B records from 10,000 doctors and 10M Patients (100 GB) Clinical trials Currently more than 30k recruiting on ClinicalTrials.gov Human proteome 160M data points (2.4GB) per sample >3TB raw proteome data in ProteomicsDB PubMed database >23M articles Hospital information systems Often more than 50GB Medical sensor data Scan of a single organ in 1s creates 10GB of raw dataCancer patient records >160k records at NCT The Driver of the Healthcare System in the 21st Century Schapranow, Telematics Conference, Feb 24, 2016
  5. 5. Schapranow, Telematics Conference, Feb 24, 2016 Our Approach Analyze Genomes: Real-time Analysis of Big Medical Data 5 In-Memory Database Extensions for Life Sciences Data Exchange, App Store Access Control, Data Protection Fair Use Statistical Tools Real-time Analysis App-spanning User Profiles Combined and Linked Data Genome Data Cellular Pathways Genome Metadata Research Publications Pipeline and Analysis Models Drugs and Interactions The Driver of the Healthcare System in the 21st Century Drug Response Analysis Pathway Topology Analysis Medical Knowledge CockpitOncolyzer Clinical Trial Recruitment Cohort Analysis ... Indexed Sources
  6. 6. Integrated Processing and Real-time Analysis of Genome Data in the Clinical Routine ■  Control center for processing of raw DNA data, such as FASTQ, SAM, and VCF ■  Personal user profile guarantees privacy of uploaded and processed data ■  Supports reproducible research process by storing all relevant process parameters ■  Implements prioritized data processing and fair use, e.g. per department or per institute ■  Supports additional service, such as data annotations, billing, and sharing for all Analyze Genomes services ■  Honored by the 2014 European Life Science Award The Driver of the Healthcare System in the 21st Century Standardized Modeling and runtime environment for analysis pipelines 6 Schapranow, Telematics Conference, Feb 24, 2016
  7. 7. ■  Query-oriented search interface ■  Seamless integration of patient specifics, e.g. from EMR ■  Parallel search in international knowledge bases, e.g. for biomarkers, literature, cellular pathway, and clinical trials Medical Knowledge Cockpit for Patients and Clinicians Linking Patient Specifics with International Knowledge The Driver of the Healthcare System in the 21st Century 7 Schapranow, Telematics Conference, Feb 24, 2016
  8. 8. ■  Integrated systems medicine based on real-time analysis of healthcare data ■  Initial funding period: Mar 2015 – Feb 2018 ■  Funded consortium partners: Systems Medicine Model of Heart Failure (SMART) Schapranow, Telematics Conference, Feb 24, 2016 The Driver of the Healthcare System in the 21st Century 8 Heart Failure Sleeping disorder Fibrosis Blood pressure Blood volume Gene ex- pression Hyper- trophyCalcium meta- bolism Energy meta- bolism Iron deficiency Vitamin-D deficiency Gender Epi- genetics
  9. 9. ■  Interdisciplinary partners collaborate on enabling real-time healthcare research ■  Initial funding period: Aug 2015 – July 2018 ■  Funded consortium partners: □  AOK German healthcare insurance company □  data experts group Technology operations □  Hasso Plattner Institute Real-time data analysis, in-memory database technology □  Technology, Methods, and Infrastructure for Networked Medical Research Legal and data protection Smart Analysis Health Research Access (SAHRA) Schapranow, Telematics Conference, Feb 24, 2016 The Driver of the Healthcare System in the 21st Century 9
  10. 10. ■  Online: Visit we.analyzegenomes.com for latest research results, slides, videos, tools, and publications ■  Offline: Read more about it, e.g. High-Performance In-Memory Genome Data Analysis: How In-Memory Database Technology Accelerates Personalized Medicine, In-Memory Data Management Research, Springer, ISBN: 978-3-319-03034-0, 2014 ■  In Person: Join us for “Cebit 2016” March 14-20, 2016 in Hanover, Germany Where to find additional information? Schapranow, Telematics Conference, Feb 24, 2016 The Driver of the Healthcare System in the 21st Century 10
  11. 11. Keep in contact with us! Dr. Matthieu-P. Schapranow Program Manager E-Health & Life Sciences Hasso Plattner Institute August-Bebel-Str. 88 14482 Potsdam, Germany schapranow@hpi.de http://we.analyzegenomes.com/ Schapranow, Telematics Conference, Feb 24, 2016 The Driver of the Healthcare System in the 21st Century 11

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