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Patient Journey in Oncology 2025:
Molecular Tumour Boards in Practice
Dr.-Ing. Matthieu-P. Schapranow
Bio Data World Congr...
■ 1998: Founded as public-private partnership in Potsdam, Germany
■ 15+ professors, 600+ B.Sc. & M.Sc. students, 170+ PhD ...
■ Long-lasting digital health expertise and access
to global network of subject-matter experts
■ Database: In-memory datab...
■ 150 MEUR national initiative to support adaption of digital health
■ HiGHmed consists of international partners from, e....
■ Case vignette: 65-year old, male, former smoker, COPD patient
■ How does the patient journey looks like?
Patient Journey...
■ Organ-specific tumor boards
■ Therapy options according to
clinical guidelines are
discussed per patient
■ Limitations:
...
State-of-the-art MTB Meetings:
Unstructured Data
Schapranow, Bio Data
World Congress, Basel,
Dec 04, 2019
Patient Journey ...
■ Multi-disciplinary exchange format for precision oncology
■ Incorporates all personal genetic dispositions
■ Applying en...
Personas and User Roles
Schapranow, Bio Data
World Congress, Basel,
Dec 04, 2019
Patient Journey in
Oncology 2025
9
Patien...
■ Lung function test + low-dose CT scan of the lung
■ AI system supports radiologists in detecting lung tissue changes
■ M...
Precision Oncology driven by Data
■ Image screening:
■ Molecular-genetic profiling:
□ Send tumor sample to laboratory for ...
Our Approach: AnalyzeGenomes.com
In-Memory Computing Platform for Big Medical Data
Schapranow, Bio Data
World Congress, Ba...
■ AI-based therapy support based on, e.g.
□ Clinical guidelines
□ Historic patient cases
□ Latest international medical
kn...
I. Clinical Process: MTB Preparation
Schapranow, Bio Data
World Congress, Basel,
Dec 04, 2019
Patient Journey in
Oncology ...
■ Variety of knowledge sources
need to be screened:
□ Variant databases,
□ Clinical trials,
□ Cancer pathways,
□ Clinical ...
World Knowledge:
Annotation of Genetic Variants by MTB Research Expert
Schapranow, Bio Data
World Congress, Basel,
Dec 04,...
■ Comparison of outcome of similar patients
■ Quantitative real-time analysis of therapy efficiency
■ Assessment of altern...
■ Knowledge is scattered across hospitals
■ Variant annotation requires a collaborative
approach
□ Searching for similar p...
World Knowledge:
Medical Knowledge Cockpit
Schapranow, Bio Data
World Congress, Basel,
Dec 04, 2019
Patient Journey in
Onc...
II. Clinical Process: MTB Meeting
Schapranow, Bio Data
World Congress, Basel,
Dec 04, 2019
Patient Journey in
Oncology 202...
■ Short-term: patient needs to be discussed
again in future tumor board meeting
■ Long-term: evaluation of success of
expe...
Stay in Contact
Dr.-Ing. Matthieu-P. Schapranow
Group Leader & Scientific Manager Digital Health Innovations
Hasso Plattne...
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Patient Journey in Oncology 2025: Molecular Tumour Boards in Practice

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The slide deck was presented at the Bio Data World Congress in Basel on Dec. 04, 2019. It shares first results from the work in the HiGHmed consortium on the use case oncology.

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Patient Journey in Oncology 2025: Molecular Tumour Boards in Practice

  1. 1. Patient Journey in Oncology 2025: Molecular Tumour Boards in Practice Dr.-Ing. Matthieu-P. Schapranow Bio Data World Congress, Basel, Switzerland Dec 04, 2019
  2. 2. ■ 1998: Founded as public-private partnership in Potsdam, Germany ■ 15+ professors, 600+ B.Sc. & M.Sc. students, 170+ PhD students ■ Since 2017 Digital Engineering Faculty of Potsdam University ■ Digital Health Center: Connected Health, Digital Health & Machine Learning, Personalized Medicine, In-Memory Computing for Digital Health Hasso Plattner Institute Key Facts Patient Journey in Oncology 2025 2 Schapranow, Bio Data World Congress, Basel, Dec 04, 2019
  3. 3. ■ Long-lasting digital health expertise and access to global network of subject-matter experts ■ Database: In-memory database technology for real-time data analysis ■ Methods: Latest artificial intelligence and machine learning algorithms optimized for scalable high-throughput processing ■ High-throughput processing of *omics data and big medical data modalities Working Group In-Memory Computing for Digital Health Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 3
  4. 4. ■ 150 MEUR national initiative to support adaption of digital health ■ HiGHmed consists of international partners from, e.g. hospitals, academia, and industry. ■ Clinical Use Cases □ Oncology □ Cardiology □ Infection control ■ Education: Curriculum for experts, e.g. data scientists, data stewards Medical Informatics Initiative HiGHmed Consortium Schapranow, Artificial vs. Human Intelligence, Dec 11, 2019 Lecture Series on Global Health 4
  5. 5. ■ Case vignette: 65-year old, male, former smoker, COPD patient ■ How does the patient journey looks like? Patient Journey: Lung Cancer in 2025 Screening, Diagnosis, Treatment, and Prevention Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 5
  6. 6. ■ Organ-specific tumor boards ■ Therapy options according to clinical guidelines are discussed per patient ■ Limitations: □ Classification of cancer by finding site □ Personal genetic dispositions hardly taken into account □ Molecular-genetic data is rarely used State-of-the-art Tumor Boards Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 6 https://www.nct-heidelberg.de/en/for-patients/treatment/tumor-board.html
  7. 7. State-of-the-art MTB Meetings: Unstructured Data Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 7
  8. 8. ■ Multi-disciplinary exchange format for precision oncology ■ Incorporates all personal genetic dispositions ■ Applying engineering methodologies to support clinical findings Motivation: Molecular Tumor Boards enabling Precision Oncology Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 8
  9. 9. Personas and User Roles Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 9 Patient and treating physician Wet Lab Bio- informatician Moderator and MTB attendees MTB research expert Documenter
  10. 10. ■ Lung function test + low-dose CT scan of the lung ■ AI system supports radiologists in detecting lung tissue changes ■ Minimal invasive CTC test reveals cells carrying relevant genetic changes, e.g. EGFR+ and ERBB2+ ■ à Biopsy from lung validated hypothesis Patient Journey: Lung Cancer in 2025 Diagnosis Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 10 https://www.plattform-lernende-systeme.de/anwendungsszenario-2.html
  11. 11. Precision Oncology driven by Data ■ Image screening: ■ Molecular-genetic profiling: □ Send tumor sample to laboratory for DNA extraction □ Sequencing of tumor DNA with NGS technology < 20hrs à 500GB+ raw data □ Process raw data, i.e. perform alignment, variant calling □ Identifying relevant variants and annotating them requires access to global medical knowledge, e.g. latest clinical guidelines and similar cases Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 11
  12. 12. Our Approach: AnalyzeGenomes.com In-Memory Computing Platform for Big Medical Data Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 12 In-Memory Computing Platform Extensions for Life Sciences Data Exchange, App Store Access Control, Data Protection Fair Use Statistical Tools Real-time Analysis App-spanning User Profiles Combined and Linked Data Genome Data Cellular Pathways Genome Metadata Research Publications Pipeline and Analysis Models Drugs and Interactions Drug Response Analysis Pathway Topology Analysis Medical Knowledge CockpitOncolyzer Clinical Trial Recruitment Cohort Analysis ... Indexed Sources
  13. 13. ■ AI-based therapy support based on, e.g. □ Clinical guidelines □ Historic patient cases □ Latest international medical knowledge and publications ■ à Fully compliant with latest clinical guidelines surgery can be performed Patient Journey: Lung Cancer in 2025 Treatment Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 13 https://we.analyzegenomes.com/mkc/digiGipfel2018/
  14. 14. I. Clinical Process: MTB Preparation Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 14 ■ Patient is sent to MTB by treating oncologist ■ Tissue sample is processed in wet lab ■ Bioinformatics department processes sequenced DNA reads ■ MTB research expert annotates mutations to identify treatment alternatives: □ Time-intense □ May consume hours to days
  15. 15. ■ Variety of knowledge sources need to be screened: □ Variant databases, □ Clinical trials, □ Cancer pathways, □ Clinical guidelines, and □ Primary literature World Knowledge: Knowledge Bases for Precision Oncology Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 15
  16. 16. World Knowledge: Annotation of Genetic Variants by MTB Research Expert Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 16 ■ Understand biological function of genetic variants ■ Assess drugability of genetic changes ■ Derive treatment suggestions
  17. 17. ■ Comparison of outcome of similar patients ■ Quantitative real-time analysis of therapy efficiency ■ Assessment of alternative therapy options ■ Break-through: bringing clinical trials to participants ■ à Adjuvant therapy based on specific combination of chemotherapy is selected Patient Journey: Lung Cancer in 2025 Treatment Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 17 https://we.analyzegenomes.com/mkc/digiGipfel2018/
  18. 18. ■ Knowledge is scattered across hospitals ■ Variant annotation requires a collaborative approach □ Searching for similar patients □ Shared knowledge bases Community Knowledge Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 18
  19. 19. World Knowledge: Medical Knowledge Cockpit Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 19 ■ Query oriented search interface ■ Seamless combination with patient specifics and annotation tools ■ Widget structure for extensibility, e.g. for integration of variant databases
  20. 20. II. Clinical Process: MTB Meeting Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 20 ■ Treating physician introduces the case ■ Moderator presents case information and treatment suggestions to MTB attendees ■ Documenter records final MTB suggestions
  21. 21. ■ Short-term: patient needs to be discussed again in future tumor board meeting ■ Long-term: evaluation of success of experimental treatment suggestions to collect evidence for future patients ■ Vision: personalized notifications for patients for re-examination III. Follow-Up Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 21
  22. 22. Stay in Contact Dr.-Ing. Matthieu-P. Schapranow Group Leader & Scientific Manager Digital Health Innovations Hasso Plattner Institute Digital Health Center Rudolf-Breitscheid-Str. 187 14482 Potsdam, Germany we.analyzegenomes.com @AnalyzeGenomes Schapranow, Bio Data World Congress, Basel, Dec 04, 2019 Patient Journey in Oncology 2025 22

The slide deck was presented at the Bio Data World Congress in Basel on Dec. 04, 2019. It shares first results from the work in the HiGHmed consortium on the use case oncology.

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