Dr. Saurabh kr. Bajpai
2.Risk factors in atherosclerosis
3.Atherosclerotic plaque formation
5.Role of PUFA in Atherosclerosis
6.New endogenous anti-inflammatory and
proresolving lipid mediators
walls as a
Risk Factors in Atherosclerosis
Major risk factors
1) Major Constitutional risk factors:
2) Major Acquired risk factors:
iii. Diabetes mellitus
Minor Risk Factors:
2. Hormones: Oestrogen deficiency
3. Physical inactivity
4. Stressful life
PUFA stands for Poly-Unsaturated Fatty Acid. In
chemical terms, that means that the fatty acid has
more than one (poly) double bond in the carbon
There are two main types of PUFA’s —
omega-3 polyunsaturated fatty acids
omega 6 polyunsaturated fatty acids.
Protective role of n-3 PUFA in
1. Resolation of inflammatory process
2. Change in biological function of cell
3. Plaque stabalization
4. Change in serum lipid profile
5. Improved flow mediated arterial dilation
HOW n-3 PUFA reduses inflammation?
Compete with n-6 fatty acids for
and leukotriene synthesis
Bind reactive oxygen species
2.Change in biological function of cell
Incorporation of EPA and DHA in to CM
Influences it,s organisation,fludity, and
Modulate K,Na,andCa channel activities
Induction of NO release
Anti-inflammatory and proresolving
lipid mediators generated from PUFAs
Through their positive antithrombotic, lipidlowering, proendothelial functional activities, n-3
PUFAs play an important role on the
mechanisms of atherosclerosis
LC-n3-PUFAs significantly interact with
inflammation-related mechanisms, such as
endothelial activation, modification of eicosanoid
metabolism, and resolution of the inflammatory
1.Emken EA. In: Proceedings from the Scientific Conference on Omega-3 Fatty Acids in Nutrition,
Vascular Biology, and Medicine. Dallas, TX: American Heart Association, 1995, pp. 9-18.
2.Horrobin DF and Manku MS. In: Omega-6 Essential Fatty Acids. Horrobin DF, ed. New York, NY:
Alan R. Liss, 1990, pp. 21-53.
3.Ferretti A and Flanagan VP. Prostaglandins Leukot Essent Fatty Acids. 1996;54:451-455.
4. Ratnayake WMN and Chen Z-Y. Lipids. 1996;31(Suppl):S279-S282.
5.Ackman RG and Cunnane SC. In: Advances in Applied Lipid Research. Padley FB, ed. London: JAI
Press Ltd., 1992, pp. 167-215.
6. Houwelingen AC v and Hornstra G. World Rev Nutr Diet. 1994;75:175-178.
7. Salem Jr N, et al. Lipids. 1996;31(Suppl):S153-S156. 16. Brossard N, et al. Am J Clin