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Seminario Colangiocarcinoma

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Seminario Colangiocarcinoma

  1. 1. ColangiocarcinomaSandra Milena Acevedo RuedaMD Residente 2do añoMedicina Interna UNAB
  2. 2. ColangiocarcinomaKhan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748El término “colangiocarcinoma” incluye los cánceres de todos los conductos biliares(intrahepático, perihiliar y extrahepático distal)20% son intrahepáticos50-60% son perihiliares, envuelven la bifurcación de los conductos
  3. 3. ColangiocarcinomaEdge SB, Compton CC. The American Joint Committee on Cancer: the 7th editionof the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol2010;17:1471e4.BismutheCorlette classification of biliarystrictures
  4. 4. ColangiocarcinomaKhan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748-Segundo tumor más frecuente – hepático-1500 muertes en UK cada año-Factores de riesgo 30% casos-Colangitis esclerosante primaria (Enf. inflamatoria intestinal)
  5. 5. ColangiocarcinomaEstablished risk factors for cholangiocarcinoma (CC)Khan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748
  6. 6. ColangiocarcinomaKhan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748-Cirrosis-Hepatitis B, C-Diabetes-Hígado graso-Alcohol-Cigarrillo-Toxinas: Nitrosaminas, dioxinas, cloruro vinilFR Menos comunes
  7. 7. ColangiocarcinomaMain macroscopic types of cholangiocarcinoma (CC)Khan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748
  8. 8. ColangiocarcinomaEdge SB, Compton CC. The American Joint Committee on Cancer: the 7th editionof the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol2010;17:1471e4.90% son Adenocarcinomas
  9. 9. ColangiocarcinomaKhan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748 Características clínicas Laboratorios Marcadores tumorales Inmunohistoquímica!
  10. 10. ColangiocarcinomaKhan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748Inactivación de genes supresores tumoralesp53, Smad-4, bcl-2 y p16Mutaciones de oncogenes K-ras, p53, c-erbB-2 yc-neu
  11. 11. ColangiocarcinomaEdge SB, Compton CC. The American Joint Committee on Cancer: the 7th editionof the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol2010;17:1471e4.IgG4 cholangiopathyshould be excluded in suspected cases ofCC by testing for increased IgG4 in serumand biliary samples
  12. 12. ColangiocarcinomaKhan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748 ImágenesUltrasonografíaTAC espiral o alta resoluciónRMN
  13. 13. ColangiocarcinomaMRCP had superior sensitivity (96%), specificity(85%) and accuracy (91%) compared with ERCP(80%, 75% and 78%, respectively) for differentiatingbetween CC and benign strictures
  14. 14. ColangiocarcinomaKhan SA, Davidson BR, Goldin RD, et al. Gut (2012).doi:10.1136/gutjnl-2011-301748
  15. 15. Asian Pac J Cancer Prev. 2013;14(3):1623-7.Factors affecting survival timeof cholangiocarcinoma patients: aprospective study in northeast Thailand.Woradet S, Promthet S, Songserm N, Parkin DMColangiocarcinoma
  16. 16. Ann Clin Lab Sci. 2013 Spring;43(2):195-210.Cholangiocarcinoma: risk factors,environmental influences and oncogenesis.Al-Bahrani R, Abuetabh Y, Zeitouni N, Sergi C.Colangiocarcinoma
  17. 17. World J Gastroenterol. 2013 Apr28;19(16):2456-65.Annexin A1: A new immunohistological markerof cholangiocarcinoma.Hongsrichan N, Rucksaken R, ChamgramolY, Pinlaor P, Techasen A, YongvanitP, Khuntikeo N, Pairojkul C, Pinlaor S.Colangiocarcinoma
  18. 18. Gracias!

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