Amikacin

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Amikacin

  1. 1. Aminoglycosides<br />Potent bactericidal antibiotics <br />
  2. 2. Aminoglycosides<br />Strong Aerobic, gram-negative and gram-positive bacterial coverage <br />Rapid concentration-dependent killing and post-antibiotic effect <br />Used in the treatment of severe infections of urinary, intra-abdominal and sepsis etc.<br />But,<br />
  3. 3. Major limitation<br />
  4. 4. Aminoglycosidenephrotoxicity cascade<br />Amer J Med 1986;80:105-114<br />
  5. 5. Antimicrob Agents Chemother 1999;43:1003-12<br />
  6. 6. AminoglycosideOtotoxicity cascade<br />

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