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Highly Crosslinked UHMWPE 
In THR TKR ARTHROPLASTY 
(Polyethylene ) 
DR.SANDEEP AGRAWAL 
Consultant Orthopaedic Surgeon 
A...
POLYETHYLENE
Timeline of Development of UHMWPE
UHMWPE
Naming of UHMWPE 
(Hoechst/Celanese, 1996) 
 GUR (Granular, UHMWPE, Ruhrchemie) 
 A,B,C,D HP (eg. GUR 1050, GUR 4150 HP)...
Contemporary Highly 
Crosslinked UHMWPE
Manufacturing of UHMWPE Implants
Irradiation in Air 
MW ↓→ strength ↓
Irradiation in Inert Air
DurationTM Stabilization Process 
(1995, Howmedica) 
Precursor of Highly crosslinked 
Stabilization by heating 37-50 ˚C fo...
Longevity Crosslinked Polyethylene 
Polyethylene is a part 
crystalline, part 
amorphous structure 
Crystalline 
Amorphous...
Comparision of 
Highly Crosslinked UHMWPE 
Kyocera, 
Osteonics Zimmer Zimmer Japan 
AeonianTM 
Bar stock 
35KGyGamma 
irra...
Alternative Bearing Material seek improved 
function, longer survivorship 
Ceramic head- on-metal 
cup 
Michael Piechocki,...
The Basis for a Second-generation Highly 
Crosslinked UHMWPE 
 First generation Highly Cross-linked 
(UHMWPE) 
 Melted h...
The Basis for a Second-generation Highly 
Crosslinked UHMWPE (X3 HXPE) 
 (X3 HXPE) uses a sequential irradiation and 
ann...
Alternative Bearing Material seek improved 
function, longer survivorship 
Ceramic head- on-metal 
cup 
Michael Piechocki,...
Highly Crosslinked UHMWPE In THR TKR ARTHROPLASTY (Polyethylene ),DR.SANDEEP AGRAWAL Agrasen Fracture Hospital Gondia Maha...
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Highly Crosslinked UHMWPE In THR TKR ARTHROPLASTY (Polyethylene ),DR.SANDEEP AGRAWAL Agrasen Fracture Hospital Gondia Maharashtra

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Highly Crosslinked UHMWPE
In THR TKR ARTHROPLASTY
(Polyethylene ),DR.SANDEEP AGRAWAL
Agrasen Fracture Hospital
Gondia
Maharashtra
Crucial for Revision Joint Replacemant Surgeries,
THR(Total Hip Replacement ),TKR (Total Knee Replacemant ),
Hip Knee Pain

Published in: Health & Medicine

Highly Crosslinked UHMWPE In THR TKR ARTHROPLASTY (Polyethylene ),DR.SANDEEP AGRAWAL Agrasen Fracture Hospital Gondia Maharashtra

  1. 1. Highly Crosslinked UHMWPE In THR TKR ARTHROPLASTY (Polyethylene ) DR.SANDEEP AGRAWAL Consultant Orthopaedic Surgeon Agrasen Fracture Hospital Gondia Maharashtra
  2. 2. POLYETHYLENE
  3. 3. Timeline of Development of UHMWPE
  4. 4. UHMWPE
  5. 5. Naming of UHMWPE (Hoechst/Celanese, 1996)  GUR (Granular, UHMWPE, Ruhrchemie)  A,B,C,D HP (eg. GUR 1050, GUR 4150 HP)  A: 1-Germany, 4-USA, Texas  B: 1-Ca stearate, 0-none  C: 2- MW=2-4million, 5- MW>4million  D: 0 no meaning  HP: High Purity, meets the ASTM requirement (American Society for Testing and Materials)
  6. 6. Contemporary Highly Crosslinked UHMWPE
  7. 7. Manufacturing of UHMWPE Implants
  8. 8. Irradiation in Air MW ↓→ strength ↓
  9. 9. Irradiation in Inert Air
  10. 10. DurationTM Stabilization Process (1995, Howmedica) Precursor of Highly crosslinked Stabilization by heating 37-50 ˚C for 144 hrs Volumetric wear 32% less than air-irradiated control
  11. 11. Longevity Crosslinked Polyethylene Polyethylene is a part crystalline, part amorphous structure Crystalline Amorphous Free Radical Site Heated to Melt the Crystalline Phases Heat Heat Cooled slowly to return to its original structure Crosslink
  12. 12. Comparision of Highly Crosslinked UHMWPE Kyocera, Osteonics Zimmer Zimmer Japan AeonianTM Bar stock 35KGyGamma irradiation Machined after XL Pack in Nitrogen 25-40 kGy Gamma Sterilization DePuy- Dupont Zimmer Smith & Nephew
  13. 13. Alternative Bearing Material seek improved function, longer survivorship Ceramic head- on-metal cup Michael Piechocki, Fisher J, Orthopedics Today International, July/August, 2006, p17-8
  14. 14. The Basis for a Second-generation Highly Crosslinked UHMWPE  First generation Highly Cross-linked (UHMWPE)  Melted highly crosslinked polyethylene may be susceptible to fatigue cracking, and  Annealed highly crosslinked polyethylene may be susceptible to in vivo oxidation. Dumbleton JH, D'Antonio JA, Manley MT, Capello WN, Wang A. Clin Orthop Relat Res. 2006 Sep 28
  15. 15. The Basis for a Second-generation Highly Crosslinked UHMWPE (X3 HXPE)  (X3 HXPE) uses a sequential irradiation and annealing process.  Mechanical strength properties preserved with the highest survivorship in functional fatigue testing.  Free radical content is low, and performance under accelerated aging is the same as virgin UHMWPE  Crystallinity, density, and tensile strength was unchanged by oxidative challenge.  Volumetric wear rate very similar to metal-on-metal articulations  Wear particles were the same size as those produced from conventional UHMWPE. Dumbleton JH, D'Antonio JA, Manley MT, Capello WN, Wang A. Clin Orthop Relat Res. 2006 Sep 28
  16. 16. Alternative Bearing Material seek improved function, longer survivorship Ceramic head- on-metal cup Michael Piechocki, Fisher J, Orthopedics Today International, July/August, 2006, p17-8 (X3 HXPE)

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