Dr Samsuddin Khan
MSF Mumbai
HIV/DRTB Project
 Study design: prospective, observational cohort study
 Setting and study population: Mumbai, Patient on ART and MDR-
TB...
71%, 63% and 40% of patients experienced one
or
more mild, moderate or severe AE respectively
151 episodes of AE
Life-thre...
 adverse reactions occurred frequently but were
managed mostly on an out-patient basis.
 no co-infected patient in this ...
Adverse side effect in HIV/MDRTB treatment
Adverse side effect in HIV/MDRTB treatment
Upcoming SlideShare
Loading in …5
×

Adverse side effect in HIV/MDRTB treatment

373 views

Published on

Adverse side effect in HIV/MDRTB treatment

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
373
On SlideShare
0
From Embeds
0
Number of Embeds
6
Actions
Shares
0
Downloads
10
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Adverse side effect in HIV/MDRTB treatment

  1. 1. Dr Samsuddin Khan MSF Mumbai HIV/DRTB Project
  2. 2.  Study design: prospective, observational cohort study  Setting and study population: Mumbai, Patient on ART and MDR- TB treatment between May 2007 and September 2011  Treatment protocol and follow-up: Individualized therapy, ambulatory, community-based program, WHO Guideline  Patient characteristics: 67 HIV/MDR-TB co-infected patients (53 bacteriologically confirmed and 14 unconfirmed) who had received at least two weeks of anti-MDR-TB therapy, Twenty-nine (43.3%) of them were female and two (3.0%) were transgender individuals. The median age of these patients was 35.5 years (Interquartile Range [IQR] 30.5–42) and the median duration of MDR-TB therapy at the time of analysis was 10 (range 0.5–30) months.
  3. 3. 71%, 63% and 40% of patients experienced one or more mild, moderate or severe AE respectively 151 episodes of AE Life-threatening events were rare in this Mumbai cohort 27 patients (40%) required permanent discontinuation of at least one drug Eleven were hospit alized for AE
  4. 4.  adverse reactions occurred frequently but were managed mostly on an out-patient basis.  no co-infected patient in this cohort required permanent discontinuation of anti-TB treatment or ART  Specific AE, such as hypothyroidism, hypokalaemia, loss of hearing, seizures, tendonitis and arthralgia, were most likely due to second-line TB drugs. No hepatitis occurred in this cohort  Co-administration of ART and second-line TB treatment rarely causes life-threatening AE or leads to permanent discontinuation of treatment

×