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Effect of sympathomimetics on isolated heart of frog

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Experimental Pharmacology(Virtual lab)
Effect of sympathomimetics( epinephrine - norepinephrine- isoprenaline )on isolated heart of frog

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Effect of sympathomimetics on isolated heart of frog

  1. 1. Stimulatory drugs on isolated heart By Dr Sameh AM abdel-ghany
  2. 2. Alpha blockers • Alpha 1 and alpha 2: phentolmaine, phenoxybenzamine and tolazoline. • Alpha 1: prozosin, doxazosin and terazosin. • Alpha 2: yohmbine
  3. 3. Beta blockers • Beta1, beta2: propranolol • Beta 1: metoprolol and atenolol • Beta 2: butoxamine
  4. 4. Stimulation of isloated heart with sympathomimetics  To increase cardiac contractilty with Sympathomimetics:  Stimulate B1 receptors : e.g • Adrenaline • Noradrenaline • Isoprenaline
  5. 5. Stimulation of heart with Epinephrine Steps: 1.Inject Epinephrine produces ↑ in both HR and contractility. 2.Try other B1 stimulants e.g. Norepinephrine and Isoprenaline 3.Inject B1- Blocker e.g Propranolol 4.Inject Epinephrine rapidly before the action of propranolol ends No effect of epinephrine 5.Try other B1 stimulants e.g. Norepinephrine and Isoprenaline after propranolol
  6. 6. THANK YOU

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