Jaundice

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Jaundice

  1. 1. Help me Ibecome a yellowman
  2. 2. Why I have this color ?Jaundice is caused by increased amounts of bilirubinin the blood.Bilirubin is a by-product of the daily naturalbreakdown and destruction of red blood cell in thebody. The hemoglobin molecule that is released intothe blood by this process is split, with the heme portionundergoing a chemical conversion to bilirubin.Normally, the liver metabolizes and excretes thebilirubin in the form of bile. However, if there is adisruption in this normal metabolism and/orproduction of bilirubin, jaundice may result.
  3. 3. Causes of jundice Pre-hepatic (before bile is made in the liver): Malaria, sickle cell cerises, spherocytosis, thalassimia ,deficiency (G6PD),drugs or other toxins, and autoimmunedisorders. Hepatic (the problem arises within the liver): hepatitis (commonly viral or alcohol related),cirrhosis, drugsor other toxins, Crigler-Najjar syndrome, gilberts syndromeand cancer . Post-hepatic (after bile has been made in the liver): gallstone in the bile ducts, cancer (pancreatic andgallbladder/bile duct carcinoma),strictures of the bile ducts,cholongitis ,congenital malformations, pancritis,parasites,pregnancy and newborn jaundice .
  4. 4. Type of jaundice acholuric jaundice jaundice without bilirubinemia, associated withelevated unconjugated bilirubin that is not excreted by the kidney. acholuric familial jaundice hereditary spherocytosis. breast milk jaundice elevated unconjugated bilirubin in somebreast-fed infants due to the presence of 5-β-pregnane-3-α-20-β-diol inbreast milk, which inhibits glucuronyl transferase conjugating activity,or to dehydration. cholestatic jaundice that resulting from abnormal bile flow in theliver. hemolytic jaundice that due to increased production of bilirubinfrom hemoglobin under conditions causing accelerated degradation oferythrocytes. hepatocellular jaundice that due to injury to or disease of livercells. hepatogenic jaundice , hepatogenous jaundice that due todisease or disorder of the liver.
  5. 5. Type of Jaundice leptospiral jaundice Weils syndrome. mechanical jaundice obstructive j. neonatal jaundice , jaundice of the newbornicterus neonatorum.. nuclear jaundice kernicterus. obstructive jaundice that due to blocking of bile flow. physiologic jaundice mild icterus neonatorum lastingthe first few days of life. retention jaundice that due to inability of the liver todispose of the bilirubin provided by the circulating blood.
  6. 6. Newborn Jaundice
  7. 7. Jaundice symptomsyellow discolorationof the skin, mucousmembranes, and thewhites of the eyes.light-coloredstools,dark-coloredurineAbdominal painNausea andvomitingitchingFever andweaknessWight loss (lossof appetite)swelling of thelegs andabdomen

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