Biomalaysia 2006 Award Winning Abstract


Published on

  • Be the first to comment

  • Be the first to like this

No Downloads
Total views
On SlideShare
From Embeds
Number of Embeds
Embeds 0
No embeds

No notes for slide

Biomalaysia 2006 Award Winning Abstract

  1. 1. MALAYSIA TECHNOLOGY EXPO (MTE) 2006. PWTC, 23-25 February 2006, Kuala Lumpur. AWARD: SILVER MEDAL SAIFUL IRWAN BIN ZUBAIRI AND NURHAFZAN ANIS BINTI ISMAIL Chemical Engineering Pilot Plant (CEPP), Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor. Tel. Office: +607-5532595 Fax no.: +607-5569706 e-mail: OR MozzieRID™ Natural Aromatic Skin Wipe AbstractRepellents are commonly used for personal protection against mosquitoes worldwide. Theyare one of the most effective devices used in the control of mosquito-borne tropicaldiseases. There are many effective repellents on the market now containing syntheticchemical active ingredients such as DEET (Autan®, Bayer), IR3535 and KBR-3023. However,there is increasing concern with their toxicity and risks to human being. The novel feature ofthis invention is the formulation itself wherein this skin wipe consisted of single repellent oilonly plus a Hibiscus gelatin to overpower human odours and help to cool the body heatduring perspirancy, thus deflecting mosquitoes away. The bioactive compound of concernconsisted in this invention is geraniol. Geraniol is extracted from Pelargonium radula which iswidely available locally and known as Jeremin. This particular oil posed a styptic orastringent effect which contracts the tissues or blood vessels when bleeding. Moreover, aHibiscus gelatin is added to the formulation to cool down the body heat, which producedcarbon dioxide (CO2) plus heat wave from the skin via heat transfer mechanism. A skin wipeis usually comprising a low cost and biodegradable porous sheet (cellulosic fibrous)impregnated with an oil in water emulsion. This skin wipe contained a polymeric bead whichis useful for treating the human skin or environmental surfaces by providing controlledrelease of functional ingredient. Various mosquito-transmitted illnesses (including malaria,dengue and yellow fever) are still a serious public health problem in the most developingcountries. Therefore, a search for an alternative effective insect repellent, which is also userfriendly, mobile, safer and cheaper than the existing one seems are able to be fullydeveloped and justified.Keywords: Repellent, mosquito-borne disease, styptic, skin wipe, oil-in-water emulsion, geraniol oil, Hibiscus gelatin.
  2. 2. MALAYSIA TECHNOLOGY EXPO (MTE) 2006. PWTC, 23-25 February 2006, Kuala Lumpur. AWARD: BRONZE MEDAL NURHAFZAN ANIS BINTI ISMAIL AND SAIFUL IRWAN BIN ZUBAIRI Chemical Engineering Pilot Plant (CEPP), Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor. Tel. Office: +607-5532595 Fax no.: +607-5569706 e-mail: OR Fever-Coolant™ Sachet AbstractFever or pyrexia is an adaptive mechanism of the body to react against pathogens. Thecore body temperature is elevated to levels which denatures, debilitate or kill the pathogen.Unfortunately, there are circumstances when fever accelerates to temperature where thebody is at risk of devastating its own cells and should be brought under control withsuppressive medication. The novel feature of this invention is to stabilize fluctuating bodytemperature during fever via heat transfer mechanism (conduction and surface convective)using the natural plant-based formulation, which involves the negative feedbackmechanism. Hibiscus rosa-sinensis Linn leaves consist of taraxeryl acetate, β-sitosterol, highcalcium and phosphorus contents. Hence, the synergistic of these compounds contributes tothe antipyretic activity. Modern antipyretic drugs (e.g.: paracetamol) are associated withhepatotoxicity. Thus, the Fever-Coolant™ Sachet is an alternative of allopathic remedy toreduce fever especially in infants and children as it is derived from non toxic natural plant.This product is a water-based leaves extract which undergo a freeze dried method, wherethe active ingredients and minerals are very well preserved. Therefore, the efficacy andsafety of the product is ensured and it is obviously very practical for the household use.Keywords: Fever, pyrexia, pathogens, surface convective, Hibiscus rosa-sinensis, natural plant-based, negative feedback, sachet