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Friend StrataRx 2012-10-16

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Wilbanks StrataRx 2012-10-16
Wilbanks StrataRx 2012-10-16
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Friend StrataRx 2012-10-16

  1. 1. Dreaming of Tenure and IPOs while patients die: What Prevents Open Approaches to Building Better Disease Models THE CORRUPTION OF DENIAL FRIEND STRATA
  2. 2. TRUST HER SHE IS A DOCTOR
  3. 3. YET SHOULD WE?
  4. 4. AND I SHOULD KNOW
  5. 5. TRUST THE UNIVERSITIES TO HELP THE PATIENTS TO BE THE BASTIONS OF SHARING
  6. 6. GARRETT FITZERALD
  7. 7. TRUST THE COMPANIES THE BIOTECHS THE VCs
  8. 8. CTCAP
  9. 9. AND I SHOULD KNOW
  10. 10. IS THERE AN ALTERNATIVE
  11. 11. Education is derived from top-down experiential Best accuracy of clinical knowledge diagnosis = 64% (Grin, 1990) 160k new cases/year 48k deaths in 2012 in US HPI ABCDE Both intra- and inter- “ugly duckling” institutional data are siloed MD Dermoscopy Pathology Molecular ?Photos There is no standard screening program for skin lesions; seeing an MD is self directed
  12. 12. 4. give back risk-assessment & education to the citizens 1. activated citizens take skin pictures virtual cycle: continuous aggregation 2. store of data tons of data! enriching the model 3. run algorithmic challenges in the compute space
  13. 13. Networked Approaches BioMedicine Information Commons Patients/ Data Generators Citizens CURATED DATA Data TOOLS/ Analysts METHODS RAW DATA ANALYSES/ MODELS Clinicians SYNAPSE Experimentalists
  14. 14. Networked Team Approaches 1 USABLE 2 DATA PRIVACY BARRIERS 5 BioMedical Information Commons EDUCATION Patients/ Data BIOINFORMATICS Generators Citizens CURATED DATA Data TOOLS/ Analysts METHODS RAW DATA ANALYSES/ MODELS 4 Clinicians REWARDS 3 FOR SYNAPSE HOW TO Experimentalists SHARING DISTRIBUTE TASKS
  15. 15. Sage-DREAM Breast Cancer Prognosis Challenge one month of building better disease models together Caldos/Aparicio breast cancer data 154 participants; 27 countries 334 participants; >35 countries Sep 26 Status Challenge Launch: July 17 >500 models posted to Leaderboard
  16. 16. IS THERE AN ALTERNATIVE BRIDGE
  17. 17. IS THERE AN ALTERNATIVE BRIDGE
  18. 18. PEACE SIGN

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