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
RENIN ANGIOTENSIN
SYSTEM
sadaqat ali

 synthesized as a preprohormone (prorenin)
 synthesized and stored in the juxtaglomerular
apparatus of the nephron
 A...

 Plays a key role in the regulation of
 fluid and electrolyte balance
 arterial blood pressure
 Excessive activity c...

 Blood Pressure
 Increase BP
 Adrenal Cortex
 stimulate aldosterone synthesis
Actions

 Kidney
 increase proximal tubular sodium reabsorption
 inhibit the secretion of renin
Actions
 Central Nervous System
 increase secretion of vasopressin
 increase secretion of ACTH
 Cell Growth
 mitogenic for v...

 AT1 receptor → Gq-coupled receptor
 AT2 receptor → nitric oxide mediated
Receptors

 Angiotensin-Converting Enzyme Inhibitors
 Captopril, enalapril
 Angiotensin Receptor Blockers
 Losartan, valsartan,...

 CNS → neurotransmitter
 GIT → transmitter in ENS and as a local hormone
 Involved in behavior, anxiety, depression, ...
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Renin angiotensin substance p-signed

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renin angeotensin pharmaclogy

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Renin angiotensin substance p-signed

  1. 1.  RENIN ANGIOTENSIN SYSTEM sadaqat ali
  2. 2.   synthesized as a preprohormone (prorenin)  synthesized and stored in the juxtaglomerular apparatus of the nephron  An important modulator of angiotensin production RENIN
  3. 3.   Plays a key role in the regulation of  fluid and electrolyte balance  arterial blood pressure  Excessive activity can result in  hypertension  disorders of fluid and electrolyte homeostasis ANGIOTENSIN II
  4. 4.   Blood Pressure  Increase BP  Adrenal Cortex  stimulate aldosterone synthesis Actions
  5. 5.   Kidney  increase proximal tubular sodium reabsorption  inhibit the secretion of renin Actions
  6. 6.  Central Nervous System  increase secretion of vasopressin  increase secretion of ACTH  Cell Growth  mitogenic for vascular and cardiac muscle cells Actions
  7. 7.   AT1 receptor → Gq-coupled receptor  AT2 receptor → nitric oxide mediated Receptors
  8. 8.   Angiotensin-Converting Enzyme Inhibitors  Captopril, enalapril  Angiotensin Receptor Blockers  Losartan, valsartan, irbesartan, candesartan, olmesartan, telmisartan  Renin Inhibitors  Aliskiren → Inhibits catalytic activity of renin Drugs
  9. 9.   CNS → neurotransmitter  GIT → transmitter in ENS and as a local hormone  Involved in behavior, anxiety, depression, nausea, and emesis  a potent arteriolar vasodilator  causes contraction of venous, intestinal, and bronchial smooth muscle  stimulates secretion by the salivary glands  causes diuresis and natriuresis by the kidneys SUBSTANCE P

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