PREPARATION AND EVALUATION OF MOUTH DISSOLVING TABLET<br />Presented By: Under the guidance of:<br />Sachin Mr. NarendraPandey<br />
Contents<br />Literature Review<br />Introduction<br />Promising drug candidates for MDT<br />Popular Disintegrants used in MDT<br />Techniques for MDT formulation<br />Marketed Products of MDT <br />Evaluation<br />Future Planning<br />2<br />
Literature Review<br /><ul><li>Mahapatra A K, Murthy P N, Sahoo J, Biswal J, Sahoo S K Formulation design and optimization of mouth dissolving tablets of levocetirizine hydrochloride using sublimation technique. Indian J. Educ. Res. 2009; 43(1):39-45.
Shirsand S B, Suresh S, Para M S, Swamy P V, Kumar N D, Plantagoovata mucilage in the design of fast disintegrating tablets. Indian J. Pharm. Sci. 2009;41-46.
Gattani S. G, Shiyani B.G, KakadeK.N,Patil A.B, Surana S.J. Formulation and evaluation of mouth dissolving tablet of ondansetron hydrochloride by using superdisintegrants. Indian drugs. 2009; 46(1): 44-50.
Shoukri A R, Ahmed S I, Shamma N R. In vitro and in vivo evaluation of nimesulidelyohilized orally disintegrating tablets.Eur. J. Pharm. biopharm. 2009; 30: 1-10.
Goswami J P, Sharma S, Gupta G D. An effervescent and reproducible method for prepration of fast disintegrating tablets. Pharma Buzz. 2009; 4(3): 46-52.</li></ul>3<br />
Continued...<br /><ul><li>Kumar S R, Lakshmi S V P. Reprimelts: A novel approach in drug delivery systems. Pharma buzz. 2009; 4(5): 18-20
Shukla D, Chakraborty S, Singh S, Mishra B. Mouth dissolving tablets: An overview of Formuation technology. ScientiaPharmaceutica. 2009; 77: 309-326.
Fini A, Bergamante V, Ronchi C, Moraes F A C. Fast Dispersible/slow releasing ibuprofen tablets. Eur. J. Pharm. Biopharm. 2008; 69: 335-341.
Shah P P, Rajashree C M. Formulation and evaluation of primaquine phosphate taste- masked rapidly disintegrating tablet. J. Pharm. Pharmcol. 2008; 60: 1279-1285.
Rashid I, Remawi A M, Eftaiha A A,BadwanA.Chitin –Silicon Dioxide coprecipitate as a novel superdisintegrant. Indian J. Pharm. Sci. 2008; 97(11): 4955-4969.
Patel D M, Patel M M..Optimization of etorocoxib tablets prepared by sublimation technique. Indian J. Pharm. Sci. 2008; 70(1): 71-76.
Chaudhri P.D, Chaudhari S.P, Lanke S.D, Patel N. Formulation and in vitro evaluation of taste masked orodispersible dosage form of levocetirizinedihydrochloride. Indian J. Pharm. Edu. Res. 2007; 41(4): 319-327.</li></ul>4<br />
Continued...<br /><ul><li>Lakade S H, formulation development and evaluation of mouth dissolving tablets of ondansetron hydrochloride. Asian J. Pharm. 2007; 1(2-3): 150-153.
Qalaji R M M, Simons R E F, Simons J K. Fast-disintegrating sublingual epinephrine tablets: Effect of tablet dimension on tablet characteristics. Drug Dev. Ind. Pharm. 2007; 33: 523-530.
Shishu, AshimaB,Singh T. Preparation of tablets Rapidly disintegrates in the saliva containing bitter taste masked granules by compression method. Indian J. Pharm. Sci. 2007; 69(1):80-84.
Ciper M, Bodmeier R. Modified conventional hard gelatin capsules as fast disintegrating dosage form in the oral cavity. Eur. J. Pharm. biopharm. 2006; 62: 178-184.
Mizumoto T, Masuda Y, Yamamoto T, Yonemochi E, Terada K.formulation design of a novel fast-disintegrating tablet. Int. J. Pharm. 2005; 306: 83-90.
Valleri M, Mura P, Cirri M, Balllerini R. Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique.Drug Dev. Ind. Pharm. 2004; 30(5): 525-534.</li></ul>5<br />
Introduction<br /><ul><li>MDTs are also called as orodispersible tablets, quick disintegrating tablets, fast disssolving tablets, porous tablets and reprimelts.
USP and EP used the term ODT for the tablets that disperses readily and within 3 minutes in mouth before swallowing.
US-FDA defined ODT as “A solid dosage form containing medicinal substances or active ingredient which disintegrates rapidly usually with in a matter of seconds when placed on the tongue.”</li></ul>Shukla et al., Mouth Dissolving Tablet: An overview of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. <br />6<br />
Why MDT..??<br /><ul><li>Preferred route of administration
To formulate MDT which will be compatible with taste masking and other excipients</li></ul>26<br />
Frequently asked questions<br /><ul><li>How mouth dissolving tablets are better than others? </li></ul> Fast dissolving tablets are better than others because oral cavity has large blood supply, huge network of blood vessels. Mouth dissolving tablets get dissolved in the saliva and drug molecule get directly absorbed into blood stream after crossing thin epithellium of oral and tongue mucosa thus the drug acts fast, then normal oral route.<br /><ul><li>Is there is any need to take tablet with water?</li></ul> No, there is no need to take the tablet with water. As it gets dissolved in the saliva with in a few seconds<br /><ul><li>Will it be cost effective?</li></ul> Yes, simple technology and can be formulated with cheap excipients.<br /><ul><li>What is the real advantage of taking a Fast Melting Tablet? </li></ul> It allows you to take the active ingredients and/or nutrients without swallowing the pill.<br />27<br />
28<br />“If we knew what we were doing it wouldn't be RESEARCH…” ---Albert Einstein<br />