Where are We in the Search for an HIV Vaccine?

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Workshop organised by Avac, NAM, and AHPN.
London 7 November 2013

Published in: Health & Medicine, Business
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Where are We in the Search for an HIV Vaccine?

  1. 1. Roger Tatoud, Ph.D UK HIV Vaccine Consortium (UK HVC) Imperial College London 1
  2. 2. AHPN, June 2010 AHPN, November 2013 34 33.4 million of people • living with HIV 2.5 2.7 million new • 7.0 infections • 9.5 million of people in 53%need of treatment • 42% had access to 1.7 treatment • 2.0 million AIDSrelated death 0 • • • • Cure Vaccine Microbicide Changes in behaviour or technology that works 100% of the time 2
  3. 3. 3
  4. 4. 4
  5. 5. 1 Basic research Prototype Discovery & Design Pre-clinical Development 3 Early clinical trials (I/II) Late clinical trials (III/IV) Regulatory approval Marketing Post marketing compliance Patient 32 years and counting 1-2 years 2 Product Manufactur e Time taken from discovery of the pathogen to existence of the vaccine: 2-5 years 1-2 years Product Manufactur e 3-10 years • Typhoid: 105 years • Whooping cough: 89 years • Polio: 47 years • Measles: 42 years HIV: 35-55 years? 5
  6. 6. Commercialisation Industry Acad. 1 Partners Case for support IP Contract Tox Funding Product GMP Lab Dissemination Trial ICH-GCP QP PPI Stats CTU NHS Phase II? 6
  7. 7. 2 http://www.vaccineenterprise.org/Benchtoclinic 7
  8. 8. 3 http://www.ct-toolkit.ac.uk/ 8
  9. 9. Structur e& function Cat “HIV” Basic research Prototype Discovery & Design STEP & HVTN505 Louis Picker CMV UK HVC Spoke 003 Pre-clinical Development RV144 (Thai Trial) Early clinical trials (I/II) 32 years and counting Late clinical trials (III/IV) CAPRISA Regulatory approval Marketing Post marketing compliance Patient PrEP (USA) iPrEX 1-2 years Product Manufactur e 2-5 years 1-2 years Product Manufactur e 3-10 years 9
  10. 10. • Long, complex, slow process • A range of expertise that are not always at hand • Collaborations • Trials & Errors • Reasons to be hopeful • Beware of the hype • Involving the public 10

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