Anatomy unit 3 cardio and respiratory system hematopoiesis and hemostasis notes
Unit 3 Notes:
• The process of blood cell formation and
• All blood cells originate from the stem cell the
• If it becomes a red blood cell:
– Hemocytoblast Erythroid Stem Cell RBC
• If it becomes a Lymphocyte white blood cell:
– Hemocytoblast Lymphoid Stem Cell Lymphocyte
• If it becomes a Non-Lymphocyte white blood cell:
– Hemocytoblast Myeloid Stem Cell Neutrophil,
Basophil, Monocyte, Eosinophil
(2) Red Blood Cell Development
• As red blood cells develop they increase
• Once hemoglobin production reaches
maximum, ALL organelles are ejected.
– This gives red blood cells their biconcave
– This also means red blood cells contain no
nucleus or anything!
(3) Making More RBC’s
• Red Blood Cells are produced within your bone
Protein released from the kidneys which stimulates
the production of RBC’s from the bone marrow.
• Cause for Release of Erythropoietin:
– Low RBC count
– Low oxygen levels
• Body stops producing / releasing erythropoietin when
RBC / oxygen numbers are back at homeostasis.
• The process of blood clotting.
• Occurs in 3 Phases:
– Vascular Phase
• Goal: Constrict the blood vessels as much as possible to
decrease blood flow.
– Platelet Phase:
• Goal: Stick platelets to sides of torn blood vessels to
patch up hole.
– Coagulation Phase:
• Goal: Form the final mesh-net that will full cover the hole
and seal up the blood vessels.
(5) The Vascular Phase
Blood vessel tears.
Serotonin is released from torn vessel cells.
Serotonin triggers vasoconstriction of blood
Blood flow temporarily slowed or
(6) The Platelet Phase
(This begins at the same time as the Vascular Phase.)
1. The same torn vessel cells release Von Willebrand
2. Free-Floating platelets adhere to Von Willebrand
3. Adhered platelets release Thromboplastin AND
4. Thromboxane causes further vasoconstriction of
(7) The Coagulation Phase Pt 1
THE EXTRINSIC PATH
with Calcium and
THE INTRINSIC PATH
1. Thromboplastin binds
with Calcium and AntiHemolytic Cofactor.
Calcium + Phospholipid =
Proconvertin binds with
Stuart Prower Enzyme
2. Thromboplastin +
Calcium + AntiHemolytic Cofactor =
Proconvertin + Stuart
Prower = “Prothrombin”
(8) The Coagulation Phase Pt 2
1. Prothrombin binds with Proaccerin Cofactor.
2. Prothrombin + Proaccerin Cofactor = “Thrombin”
3. Thrombin binds with Fibrinogen.
4. Thrombin + Fibrinogen = “Fibrin”.
*Fibrin is the mesh net that finally seals up the
(9) After Coagulation
1. Contractile proteins in platelets bring
edges of wound and tissue together to
help close up hole.
2. Plasmin Enzyme is slowly released from
3. Plasmin will begin to degrade clot tissue to
help naturally remove scab from the body.