Thalidomide QuestionWhat role (if any) does the Federal Government have in authorizing the dispensing of the drug Thalidomide to patients suffering from multiple myeloma? What are the physical and mental effects caused by prolonged use of this drug?
Profile Patricia is a retired social worker who worked for Westchester County. She explained that her job with the County was that of Eligibility Examiner, she was responsible for approving cases for familiesthat wanted their older loved ones placed innursing homes. She also worked at a Mental Health Association for many years.
Thalidomide (tha-LIH-doh-MIDE)“A drug that is used to treat multiple myeloma in patients who have just been diagnosed, and a painful skin disease related to leprosy. It is also being studied in the treatment of other types of cancer. Thalidomide belongs to the family of drugs called angiogenesis inhibitors, also called Thalomide.” (http://www.cancer.gov/Templates/db_alpha. aspx?CdrID=45458)
Identified Concepts Seven concepts were identified: drug thalidomide, thalidomide drug interactions, multiple myeloma, Federal Government, thalidomide mental effects, thalidomide physical effects, and cancer patients. These concepts were used to conductdatabase and online searches relevant to the question asked by the patron.
Search Strategy• Free Search Engines: (Google, Ask and About.com).• Digital Libraries: (Pubmed.gov, Medline).• Non-Profit and Government Websites: (FDA.gov, AACR.org (American Association for Cancer Research), Citeulike.org and Cancer.gov).• Medical Journals: JAMA (Journal of American Medical Association, Gale Group – Health and Wellness Resource Center.• Fee-based Databases: (DIALOG, Factiva, Lexis Nexis).
Some Results• Results Free Search Engines Google Search Results:• Bombay Hospital Journal, Vol. 50, No. 3, 2008• http://www.bhj.org/journal/2008_5003_july/download/page-472-476.pdf A link that led to information published by St. Vincent’s Hospital was selected.•• Ask Search Results:• Myeloma Treatment – Cancer researchers at Manhattan-based St. Vincent’s Hospital http://www.myelomatreatment.org/news/?=66• 123 Cure – Counting Down the Day We Eliminate Multiple Myeloma was also retrieved. http://www.themmrf.org/assets/take-action_donate-now/321-brochure.pdf•• Non-Profit and Government Websites Cancer.org Results• http://www3.cancer.gov/admin/fmb/2003cj.doc• FDA Approval letter for Thalidomide•• FDA.gov Results Thalidomide Overview•• Cancer.gov http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=45458•• Medical Journals Sophie Ochonisky, MD; Josette Verroust, MD; Sylvie Bastuji-Garin, MD; Romain Gherardi, MD; Jean Revuz, MD Arch Dermatol. 1994; 130(1):66-69.