6 development of the heart akd

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6 development of the heart akd

  1. 1. Dr AnilDwivedi 1
  2. 2. OutlineEarly development with regulating Genes.Primordial Heart circulation.Partitioning of AV canal.Partitioning of Primordial Atrium.Changes in Sinus Venosus. 2
  3. 3. Formation of RA & LA.Partitioning of Primordial Ventricle & BC.Development of Cardiac Valves & Conducting System.Congenital Anomalies. 3
  4. 4. DEVELOPMENT OF HEART•CVS – 1st major system.•why?•From- •splanchnic mesoderm •paraxial & lat meso •neural crest cells.•Earliest sign – angioblastic cords. 4
  5. 5. •18 days embryo.•Dorsal view 5
  6. 6. •Angioblastic cord incardiogenic area.•Pericardial coelom. 6
  7. 7. •4th week•Effect of head fold on position ofHeart•Septum transversum-central tendonof Diaph. 7
  8. 8. •20 days•Dorsal view•Two endocardial Heart tube & lat fold. 8
  9. 9. •22 days•Formation of pericardial cavity & fusing heart tubes•Single Heart tube suspended by dorsal mesocardium 9
  10. 10. •28 days•Degeneration of central part of dorsal mesocardium•Formation of Tr. Sinus•Three layers of Heart wall. 10
  11. 11. Genetic basis of growth of heart tube 6 HLH 11
  12. 12. •Rt & Lt Heart tubes•Cranial to caudal fusion•Partial fusion of Sinus Venosus. 12
  13. 13. Subdivisions of Heart tube & their fate 13
  14. 14. 26 dayshorns of sinus Venosus 14
  15. 15. 15
  16. 16. Early Heart development & folding of primitive Heart tube• The Bulbus cordis moves Inf Ant & to the embryo Rt.• The primitive ventricle moves to Lf• The prim Atrium & Sinus venosus moves sup & post• Sinus venosus is post to atrium. 16
  17. 17. Early Heart development & folding of primitive Heart tube 17
  18. 18. Circulation through primordial Heart 18
  19. 19. Partitioning of Atrioventricular canal 19
  20. 20. Partitioning of Atrioventricular canal 20
  21. 21. Partition of the Atrioventricular canal
  22. 22. Partitioning of primordial Atrium•4th week•Septum primum•Foramen primum•Foramen secundum•Septum secundum•Foramen ovale 22
  23. 23. Partitioning of primordial Atrium 23
  24. 24. Partitioning of primordial Atrium 24
  25. 25. Partitioning of primordial Atrium 25
  26. 26. Partitioning of the primordial atrium 26
  27. 27. Changes in the Sinus Venosus 27
  28. 28. Changes in the Sinus Venosus 28
  29. 29. Changes in the Sinuatrial Orifice 29
  30. 30. Formation of the Right AtriumRt ½ primitive atriumSinus venosusRt ½ AV canal 30
  31. 31. Formation of the Right Atrium 31
  32. 32. Formation of the Left Atrium & PPV 32
  33. 33. Partitioning of primordial Ventricle 33
  34. 34. Partitioning of primordial Ventricle 34
  35. 35. Partitioning of primordial Ventricle 35
  36. 36. Partitioning of Bulbus Cordis & TA 36
  37. 37. Developments of the Cardiac Valves 37
  38. 38. Developments of the Cardiac Valves 38
  39. 39. Developments of the Cardiac Valves 39
  40. 40. Conducting system of the Heart 40
  41. 41. Anomalies of the Heart 41
  42. 42. Anomalies of the HeartAnomalies of Position• Dextrocardia 42
  43. 43. Anomalies of the HeartAnomalies of PositionEctopia Cardis 43
  44. 44. Atresia or Stenosis• Aortic valve Stenosis• Pulmonary valve Stenosis 44
  45. 45. Defective formation of septaASD• Patent oval foramen.• F>M• Probe patent foramen incomplete adh of sep sec. 45
  46. 46. Defective formation of septaASD• Ostium secundum ASD 46
  47. 47. Defective formation of septaASD• Endocardial cushion defect with Ostium primum ASD 47
  48. 48. Defective formation of septaASD• Sinus Venosus ASD• Common Atrium. 48
  49. 49. Defective formation of septaVSD- most common CHD. -25%, M>F,• Membranous – most common. 49
  50. 50. Defective formation of septaVSD• Muscular(Swiss cheese)• Single ventricle 50
  51. 51. Persistent Truncus ArteriosusFailure of-• Truncal ridges• aorticopulmonaryseptum 51
  52. 52. Transposition of Great Arteries 52
  53. 53. Tetralogy of Fallot• Pulmonary Stenosis• VSD• Overriding of aorta• Right ventricular hypertrophy Unequal div of TA 53
  54. 54. SUMMARY1. Formation and division of the heart tube;2. Partitioning of Atrioventricular canal, atrium, ventricle, and Truncus and Bulbus;3. Congenital heart diseases. 54

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