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10b dev uri system

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10b dev uri system

  1. 1. Development ofGENITAL SYSTEM Dr mohan angadi
  2. 2. Development of• Gonads (testis / ovary)• Genital ducts and glands• Uterus and vagina• External genitalia(male & female)
  3. 3. Introduction 2 embryonic structures that play an imp role in dev of UG system1. Intermediate mesoderm &2. Primitive Urogenital Sinus(UGS)-a part of cloaca.
  4. 4. Intermediate mesoderm  Click to edit the outline text format  Second Outline Level − Third Outline Level  Fourth Outline Level − Fifth Outline Level − Sixth Outline Level − Seventh Outline Level − Eighth Outline Level Ninth Outline LevelClick to edit Master text styles
  5. 5.  Click to edit the outline text format  Second Outline Level − Third Outline Level  Fourth Outline Level − Fifth Outline Level − Sixth Outline Level − Seventh Nephrogenic Outline cord LevelUrogenital ridge − Eighth Outline Level Gonadal Ninth Outline LevelClick to edit ridge Master text styles
  6. 6. Cloaca
  7. 7. Development of gonads(testis/ovary)
  8. 8. Development of genital ducts
  9. 9. • In males- mesonephric duct
  10. 10. Paramesonephric(mullarian) derivatives in males
  11. 11. ProstateInner glandular zone-mesoOuter glandular zone-endoFemale homologues ofprostate-Urethral glands &-Paraurethral glands ofSkene
  12. 12. • In females
  13. 13. mesonephric(wolffian)derivative s in females
  14. 14. Paramesonephric(mullarian) derivatives in females
  15. 15. Development of uterus & vagina
  16. 16. Female homologues ofprostate-urethral glands &-peneffdjhfgdhgffaraurethral glands of Sk
  17. 17. Dev. of vagina
  18. 18. Development of ext genitalia
  19. 19. Male urethra
  20. 20. Development of inguinalcanal/Descent of testis
  21. 21. Factors responsible for descent• Initiated by-androgens• Prompted by-differential growth• Permitted by-lengthening of ductus• Fascilitated by-gubernaculum
  22. 22. Control of differentiation of genital organs1. Cromosomal sex of individual-at fertilization2. SRY gene on short arm- production of TDF3. Testosterone –interstitial Leydig cells4. MIS – Sertoli cells
  23. 23. Applied aspects
  24. 24. Anomalies of testis-undescended testis/ ectopic testis - crptorchidism
  25. 25. Anomalies of processus vaginalis• Congenital hernia/hydrocoele• Vaginal hydrocoele• Infantile hydrocoele• Hydrocoele of cord• Interstitial hernia
  26. 26. Hermaphroditism• True• Pseudo – Female – Male• Androgen insensitivity syndrome/testicular feminization syndrome
  27. 27. Anomalies of Uterinetube,uterus and vagina
  28. 28. Anomalies of female ext genitalia• Clitoris - absent/bifid or double or enlarged(heramaphroditism)• Fusion of labia minora• Ectopic urethra in ant wall of vagina• Anomalies of hymen
  29. 29. • Vaginal fistulas – Rectovaginal fistula – Vesico vaginal fistula – Urethrovaginal fistula• Vagina duplicated/ absent/ septum
  30. 30. Anomalies of male ext genitalia• Phimosis• Hypospadias• Epispadias
  31. 31. Epispadias Click to edit the outline text format  Second Outline Level − Third Outline Level  Fourth Outline Level − Fifth Outline Level − Sixth Outline Level − Seventh Outline Level − Eighth Outline LevelNinth Outline LevelClick to edit Master text styles
  32. 32. Thank you

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