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Metabolism of zinc and its clinical significance

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A comprehensive presentation on Metabolism of Zinc and its clinical significance for MBBS,BDS,B.Tech,B.Pharma and Biotechnology students for self-study.

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Metabolism of zinc and its clinical significance

  1. 1. Metabolism of Zinc and its clinical significance Dr. RohiniC Sane
  2. 2. Zinc Metabolism Rohini C Sane
  3. 3. Zinc Metabolism Highest content ↓ BODY ZINC CONTENT -2gm SERUM ZINC LEVELS (physiological ): 100 micrograms /dl
  4. 4. Zinc Metabolism absorption of dietary Zinc : DUODENUM Inhibitors of absorption of dietary Zinc : Copper, Calcium ,Cobalt ,Iron, Phytates Zinc & Copper competitors ( Zinc used in Wilson’s Disease as it decreases dietary Copper absorption in duodenum ) Zinc storage in human body : LIVER ( Metallothionein )
  5. 5. Dietary sources of Zinc: ØDietary sources of Zinc: a) Beans b) Cheese c) Grains d) Nuts e) Meats
  6. 6. Functions of Zinc
  7. 7. Zinc Metabolism qDaily dietary Requirement- For Adults :15 mg For children: 10 mg qDaily dietary Requirement increases – Pregnancy Lactation
  8. 8. Zinc Metabolism vCauses of Zinc deficiency a) Nephrotic syndrome b) Hemolytic anemia ‘myocardial infarction’ c) Infection d) Achrodermititis ( Zinc absorption defective ) vSymptoms of Zinc deficiency a) Poor wound healing b) Lesions in skin ( of mouth , nose ,fingers ) c) Spermatogenesis d) Dermatitis/dementia / depression e) Alopecia
  9. 9. Zinc toxicity: causes and symptoms qZinc toxicity : 1. Welders : inhalation of Zinc oxide fumes 2. Rat poisons contain Zinc compounds 3. symptoms of Zinc toxicity : a) Ulcer b) Pancreatitis c) anemia d) vomiting e) Pulmonary fibrosis qsymptoms of severe of Zinc toxicity : a) Headache b) Fever c) Leukocytosis d) Anemia e) Platelet aggregation f) Phagocytosis
  10. 10. Zinc excess (toxicity ) and deficiency
  11. 11. Functions of Zinc qFunctions of Zinc 1. for > 300 enzymes Zinc is a cofactor of enzymes ( LDH ,Alkaline phosphatase ,Carbonic anhydrase , SOD , Carboxy peptidase ) 2. RNA polymerase requires Zn for protein biosynthesis . 3. Extra cellular Super oxide dismutase is Zn dependent. 4. Zn –functions as an antioxidant. 5. synthesis of retinol binding protein require Zinc 6. Zinc required for immunological functions. 7. Zinc supplementation useful for treating acute diarrhea. 8. Zinc supplementation improves birth weight of babies. 9. Zinc plays important role in “ Insulin “ storage in beta pancreatic cells 10. ( commercial Protamine = Zinc insulate ) . 11. Gusten –Saliva taste sensation
  12. 12. Functions of Zinc –cofactor of RNA polymerase RNA polymerase requires Zn for protein biosynthesis
  13. 13. Zinc –as an antioxidant 3 Extra cellular Super oxide dismutase is Zn dependent. 4. Zn –functions as an antioxidant.
  14. 14. Functions of Zinc as an antioxidant
  15. 15. Functions of Zinc as an antioxidant
  16. 16. Chaperon proteins and Zinc
  17. 17. Zinc and insulin storage in beta pancreatic cells 9. Zinc plays important role in “ Insulin “ storage in beta pancreatic cells 10. ( commercial Protamin = Zinc insulate ) .
  18. 18. Zinc as an anti -cancer agent

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