Reproductive Endocrinology




  Steroid Producing Cells
              • Adrenocortical
                Z. glomerulosa
   ...
PROBLEMS
               PROBLEMS
                            • Inguinal Hernia
                            • Inguinal Hern...
DUCTILE SYSTEM                                                MALE SEX ACT

                                              ...
EXTERNAL GENITALIA                                           REPRODUCTIVE TRACT
                                          ...
PRIMARY SEXUAL
                                                                   CHARACTERISTICS
                        ...
Age Related Changes

                PRE-PUBERTAL to PUBERTY



                SENESCENCE




XENOESTROGENS




         ...
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Reproductive Endocrinology Reproductive Endocrinology

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Reproductive Endocrinology Reproductive Endocrinology

  1. 1. Reproductive Endocrinology Steroid Producing Cells • Adrenocortical Z. glomerulosa Z. fasiculata Z. reticularis • Ovarian Follicular Luteal • Testicular (Leydig cells) Embryology • Development • Descent • Problems 1
  2. 2. PROBLEMS PROBLEMS • Inguinal Hernia • Inguinal Hernia • Vericoele • Vericoele • Cryptochidism • Cryptochidism GERM CELLS LOBULES • Seminiferous • Leydig Cells Tubules – Germ cells – Androgen producing – Sertoli Cells SERTOLI CELLS SERTOLI CELLS LEYDIG CELLS • Blood-Testis Barrier • Nourish Sperm • Phagocytosis Testosterone aromatase • Tubular fluid Estrogens • Androgen Binding Protein 5-alpha reductase • Hormone Inhibin • Increases p450 Aromatase Activity To Target Tissues • Plasminogen Activating Factor Dihydotestosterone • Increases the Synthesis of Transferrin 2
  3. 3. DUCTILE SYSTEM MALE SEX ACT ERECTION • Epididymis EJACULATION • Vas deferens • Seminal vesicles • Prostate gland FEMALE SEX ACT Titers Plasma Testosterone 0 3 6 9 1 10 20 25 Conception Birth Puberty Titers SEX DETERMINATION Plasma Testosterone • GENETIC SEX • GONADAL SEX • PHENOTYPIC SEX 0 3 6 9 1 10 20 60 Conception Birth Puberty 3
  4. 4. EXTERNAL GENITALIA REPRODUCTIVE TRACT WOLFFIAN MULLERIAN Genital Glands penis Clitoris tubercles Epididymis Oviducts Genital fold Penis shaft Labia minora Vas Deferens Uterus Urogenital Prostate Vagina sinus Seminal Vesicles Upper vagina Genital Scrotum Labia majora swelling PROBLEMS WOLFFIAN MULLERIAN -- • Lack 5-alpha ++ reductase Testosterone Mullerian Inhib. Fact. • Adrenogenital syndrome 5-alpha reductase FETAL TESTES • Androgen DHT ++ insensitivity ++ H.C.G syndrome Male External Genitalia 4
  5. 5. PRIMARY SEXUAL CHARACTERISTICS • Androgens enhance spermatogenesis • Growth and maturation of reproductive tract at puberty • Maintenance in adulthood • Libido SECONDARY SECONDARY CHARACTERISTICS FETUS CHARACTERISTICS DHT Am I sexy, Baby!? Testosterone •• Body Hair Body Hair • Epididymis • Penis •• Larynx Larynx •• Skin Skin •• Bone growth Bone growth • Vas deferens • Scrotum •• Protein synthesis Protein synthesis •• Erythropoiesis Erythropoiesis •• BMR • Seminal vesicle • Prostate BMR •• LDL’s LDL’s •• Androgen Binding Protein Androgen Binding Protein • Seminiferous tubules •• Fat Deposition Fat Deposition ADULT Testosterone DHT • Penis • Scrotum • Seminal vesicle • Prostate • Sperm production • Hair • Skeleton and muscle • Sebaceous gland • Libido • Larynx 5
  6. 6. Age Related Changes PRE-PUBERTAL to PUBERTY SENESCENCE XENOESTROGENS 6

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