[ ] OPTC 1233 F-03.doc

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[ ] OPTC 1233 F-03.doc

  1. 1. NOVA SOUTHEASTERN UNIVERSITY HEALTH PROFESSIONS DIVISION COLLEGE OF OPTOMETRY Dept: Biochemistry Course Title: Biochemistry OPTC1233 (Fall 2004) Hours: 3 hours per week Faculty: Ronald E. Block, Ph.D., Professor of Biochemistry, Course Coordinator, 262-1319, Rm 1319 Terry Bldg Edye E. Groseclose, Ph.D., Professor of Biochemistry, 262-1325, Rm 1325 Terry Bldg K. V. Venkatachalam, Ph.D., Assoc. Professor of Biochemistry, 262-1335, Rm 1335 Terry Bldg W. Grady Campbell, Ph.D., Asst. Professor of Biochemistry, 262-1369, Rm 1369 Terry Bldg Course Description: This course will enable the student to describe and understand the biochemical components of the human body, and the metabolism of these components. The biochemical basis of ocular functions will be emphasized where appropriate. Course Outline: Hours I. Introductory Aspects: Buffers 1 Amino Acids 1 Proteins 1 Plasma Proteins 1 Myoglobin/Hemoglobin 1 Nucleic Acids 1 Carbohydrates 1 Lipids 1 Introduction to Metabolism 1 Enzymes 2 II. Metabolism and its Control: Carbohydrate Metabolism 2 Citric Acid Cycle; Oxidative Phosphorylation 3 Lipid Metabolism 4 Glycogen Metabolism 2 Amino Acid Metabolism 2 Purine and Pyrimidine Metabolism 2 DNA Replication 1 RNA Synthesis 1 Protein Synthesis 1 Proteolysis 1 Cancer 1 Porphyrins and Jaundice 1 III. Specialized Tissues, Organs, Systems: Muscle Contraction 1 Endocrinology, Thyroid, Ins./Gluc., Hypo./Pit., 4 Connective Tissue Metabolism 1 Biochemistry of the Eye (Lens, Photorecep., Cornea, Eye Fl.) 4 Digestion & Absorption 1 (If time permits) COURSE POLICIES:
  2. 2. 1. General: We make constant efforts to offer a medically relevant course in biochemistry. This means that: a) Many references to clinical practice will be made in every lecture. The control of metabolism and the biochemical aspects of vision will be emphasized. b) The use of structural formulas will be limited. We will only require you to be able to recognize the structures of 30 to 40 small fundamental molecules. We will deal mainly with the words, ideas, descriptions, equations, statements, and abbreviations of biochemistry. c) We will include very little history, methods, and descriptions of individual biochemical experiments. 2. Required Textbook: Much of the material presented in lecture will be found in our required textbook. Reading assignments for each lecture or series of lectures will be announced to you in advance. When supplementary material is presented, you will be clearly notified during lecture. This year the required textbook is: Devlin, T. M. , Textbook of Biochemistry with Clinical Correlations, 5th ed., 2002, Wiley-Liss, N.Y. 3. Handouts are intended to supplement the required textbook, but not to duplicate material found in the textbook. So be sure to check out the text for what is expected as you review. Terms to define, review questions, and questions from past exams are sometimes included in our handouts. 4. Questions: We will entertain short, to the point questions which may be helpful to clarify the lecture material. Also, should we make an error while speaking or writing, please do not hesitate to correct us ; we will appreciate it. However, we have much material to cover in a limited time, so please save your longer questions for the end of the class period or an individual conference. 5. Office Hours: We strongly encourage you to make an appointment to see us to review the recent literature and discuss the study questions if you are having difficulty understanding the material. We are eager to try to help, and are sure it will be beneficial and enlightening. Otherwise, just drop in; we will try to be available most days from 9 AM to 4 PM, as well as during the lunch hour. By the way, do not waste time unnecessarily pondering over a problem which a brief visit or telephone call will enable us to help you solve. Remember to use your time wisely, because you really do not have any time to waste ! 6. Examinations and Grades: There will be three scheduled exams and a comprehensive final exam. They will cover material in the textbook, lectures, and review sessions. Questions may either be multiple-choice or require a written response. You should study for either type of question . The points will add up as follows: Two exams at 100 points: 200 Final exam (comprehensive) 100 Total Points max. 300 Your final grade will be based upon either the total number of points, or your final exam grade may serve as your course grade, if it is higher than your course average. Students are required to take each examination at the assigned time. Students who enter the room after the announcement of the start of an examination may not be allowed to take the test. Students who have an unexcused absence from an examination will not be given a make-up test, but will be given a zero for the grade. Students who have an excused absence will be allowed a make-up test to be given within 10 business days following the date of the missed examination.
  3. 3. Optometry Biochemistry - Fall 2003 Reading Assignments from Devlin Water, Buffers 6-13, 102-3, 896-8 Intro to lipids 494-502, 694-698, 728-734, 741-2, 960-3, 1175-8 Intro to carbohydrates 1172-5 Intro to amino acids 95-104, 146, 1178-9 Intro to proteins 109-122, 132-140, 387-390 Plasma proteins 105-7, 16, 372, 127-131, 140-1, 745-50 Myoglobin, hemoglobin 393-409, 132, 54 Intro to nucleic acids 28-89, 826-30, 1179 Enzymes 413-24, 426-45, 451-2 Intro to metabolism 4-5, 14-22, 505, 512-516, 618, 864-876, 925-31 Signal Transduction 925-946, 955 Cell cycle control 848-850 Genetics 45 Cancer genetics & biochemistry 180, 198, 379, 803, 952-5 Carbohydrate metabolism 597-663, 665-78 TCA cycle & ox phos 549-61, 561-82 Sickle cell anemia 112 Glycogen metabolism 643-661 Lipid metabolism (energy related) 697-704, 709-723 Lipid metabolism (non-energy related) 728-774 Amino acid metabolism 780-820 Familial hypercholesterolemia 694, 1163, 751 Folates 434-5, 528, 795, 817, 855, 1154-6 Polyamines 66, 792, 806-7 Starvation 862-885, 722, 990 Liver functions 877-898 Cytochromes P-450 465-485 Porphyrin metabolism 1063-1071 Purine and pyrimidine metabolism 826-858 DNA replication 162-179 RNA synthesis, processing 58, 208-230, 347-354 Protein synthesis 234-255 Protein targeting 263-265 Proteolysis 265-6, 272-4 Contractile systems 1016-1031, 22 Eukaryotic gene control 56, 184-186, 74-77 Connective tissue 121-126, 225, 268-271 Trauma 892-894 Coagulation 371, 1031-1049 Lens 1003-4 Photoreceptors 1006-1016 Digestion and absorption 1082-1110 Nutrition 1118-1132, 1138-1166 Endocrinology, steroid hormones 960-986 Polypeptide hormones 905-952 Lung Biochemistry 730-732 Digestive fluids 1082-1084, 1092-1094 Alcohol metabolism 416, 427, 895-896, 1149-1151 Dietary carbohydrates 1100-1103, 1125-1127, 1129-1131 Proteins and fats 1119-1124, 1126, 1128-1130 Water soluble vitamins 1148-1159 Fat soluble vitamins 1139-1148 Additional References:
  4. 4. 1. Murray, R.K., Granner, D.K., Mayes, P.A., and Rodwell, V.W., “Harper’s Biochemistry”, Appleton and Lange, 24th ed., 1996. Concise, paperbound, helpful especially if you have taken a Biochemistry course previously. 2. Scriver, Beaudet, Sly & Valle, “The Metabolic Basis of Inherited Disease”, 7th ed., 1995. Three large blue volumes of information on all the inherited diseases of metabolism. Lots of metabolism, genetics, and clinical details. 3. Stryer, L., “Biochemistry”, W.H. Freeman and Co., 4th ed., 1995. Very readable covering most of the basic topics in this course. However, the clinical case coverage is not as extensive as that of Devlin. Previously used as a text for this course. 4. Zubay, G. , “Biochemistry”, Wm. C. Brown Publishers, 4th ed., 1997. Well illustrated, good on structural details and mechanisms. 5. Smith, E.L. , et al., “Principles of Biochemistry, General Aspects; Mammalian Biochemistry”, 7th ed., 1983. Is now out of date, but is a good two-volume set which served as the model for organizing this course. Good index, well written, but it is getting too old to serve as the course text. 6. Voet, D., and Voet, J.G., “Biochemistry”, John Wiley and Sons, 2nd ed., 1995. Good overall text with detailed discussions of enzyme kinetics. 7. Matthews, C.K. and Van Holde, K.E. , “Biochemistry”, Addison-Wesley Benjamin/Cummings, 2nd ed., 1996. Good clinical material included, but long on enzyme mechanisms. 8. Kelly, “Clinical Genetics and Genetic Counseling”, 2nd ed., 1986. Good treatment of genetics, an important area not normally included in biochemistry textbooks. 9. Alberts, B. , et al., “Essential Cell Biology, An Introduction to the Molecular Biology of the Cell”, Garland Publishing, Inc., 1998. Good introduction to cell biology. NOVA SOUTHEASTERN UNIVERSITY HEALTH PROFESSIONS DIVISION COLLEGE OF OPTOMETRY BIOCHEMISTRY CALENDAR 2003 (A voluntary recitation session will be available Fridays at 4 PM) Week Monday Topics Lecture Hours 1. A. 9 Intro. Buffers, Intro. Amino Acids, Intro. Lipids 3
  5. 5. 2. A. 16 Intro. Nucleic Acids, Proteins, Myoglobin/Hemoglobin 3 3. A. 23 Intro. Metabolism, Intro. Carbohydrates, Plasma Proteins 3 4. A. 30 Enzymes I & II, Carbohydrate Metabolism-I 3 5. S. 07 (Tuesday) Glycogen I & II 3 6. S. 13 Carbohydrate Metabolism-II & III 2 7. S. 20 TCA Cycle-I & II, Oxidative Phosphorylation 3 8. S. 27 Lipid Metabolism I, II & III 2 9. O. 04 Exam Block begins 10. O. 13 Amino Acid Metabolism, Lipid Metabolism IV & V 1 11. O. 18 Purines and Pyrimidines I & II, RNA synthesis 3 12. O. 25 DNA Replication, Protein synthesis, Nutrition & Vision 3 13. N. 1 Muscle Contraction, Connective Tissue, Cornea 3 14. N. 8 Exam II, Steroids, Thyroid, Endo. Control of Calcium Metab. 3 15. N. 15 Insulin/Glucagon, Hypothalamus & Pituitary, Genetics 3 16. N. 22 Photoreceptors, Eye Fluids (Thanksgiving) 2 17. N. 29 Review, Exams Start

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